Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD39: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CD39 |
| Key Genes/Proteins | ATP, RNA, AND, Ras, App, DEMENTIA |
| Related Diseases | Ischemia, Dementia, ALS, Vascular Dementia |
Knowledge base pages for this entity
graph TD
CD39["CD39"]
CD39 -->|"interacts"| A3AR["A3AR"]
CD39 -->|"interacts"| Ischemia["Ischemia"]
CD39 -->|"interacts"| Dementia["Dementia"]
CD39 -->|"interacts"| ALS["ALS"]
CD39 -->|"interacts"| Vascular_Dementia["Vascular Dementia"]
CD39 -->|"activates"| ATP["ATP"]
CD39 -->|"inhibits"| Microglia["Microglia"]
CD39 -->|"interacts"| RNA["RNA"]
DEMENTIA["DEMENTIA"] -->|"interacts"| CD39
OLIGODENDROCYTE["OLIGODENDROCYTE"] -->|"interacts"| CD39
RNA -->|"interacts"| CD39
MICROGLIA["MICROGLIA"] -->|"inhibits"| CD39
AND["AND"] -->|"inhibits"| CD39
ATP -->|"activates"| CD39| Target | Relation | Type | Str |
|---|---|---|---|
| A3AR | interacts_with | receptor | 0.85 |
| Ischemia | interacts_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Vascular Dementia | interacts_with | disease | 0.65 |
| ATP | activates | gene | 0.60 |
| Microglia | inhibits | cell_type | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| Ras | activates | protein | 0.60 |
| App | activates | protein | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| White Matter | expressed_in | brain_region | 0.55 |
| Progenitor Cell | expressed_in | cell_type | 0.55 |
| Oligodendrocyte | expressed_in | cell_type | 0.55 |
| Microglia | expressed_in | cell_type | 0.55 |
| CX3CR1 | activates | gene | 0.55 |
| P2X7 | activates | gene | 0.55 |
| P2Y12 | activates | gene | 0.55 |
| purinergic signaling | participates_in | pathway | 0.55 |
| PSP | activates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||