cell_type

Oligodendrocyte

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Oligodendrocyte: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1484Connections

17Hypotheses

13Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	Oligodendrocyte
Associated Diseases	ALZHEIMER'S
Related Genes	IGF1
Linked Hypotheses	104 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Oligodendrocyte["Oligodendrocyte"] -->|"regulates"| Myelin["Myelin"]
    style Myelin fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| Oligodendrocyte["Oligodendrocyte"]
    style AQUAPORIN_4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MYELIN["MYELIN"] -->|"expressed in"| Oligodendrocyte["Oligodendrocyte"]
    style MYELIN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MOG["MOG"] -->|"expressed in"| Oligodendrocyte["Oligodendrocyte"]
    style MOG fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| Oligodendrocyte["Oligodendrocyte"]
    style COMPLEMENT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AQP4["AQP4"] -->|"expressed in"| Oligodendrocyte["Oligodendrocyte"]
    style AQP4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style Oligodendrocyte fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (594)

Target	Relation	Type	Str
Myelin	associated_with	structure	0.95
Alzheimer'S Disease	involved_in	disease	0.95
Myelin Degeneration	contributes_to	phenotype	0.95
Neuroinflammation	associated_with	process	0.90
Neurodegeneration	associated_with	process	0.90
Parkinson'S Disease	involved_in	disease	0.90
Neuroinflammation	mediates	process	0.90
Excitotoxicity	mediates	process	0.90
Active Lesion Rim	involved_in	phenotype	0.90
Remyelination	involved_in	process	0.90
Axonal Myelination	involved_in	process	0.85
Inflammatory Genes	upregulates	process	0.80
Myelin Sulfatide	produces	molecule	0.80
Myelin	regulates	entity	0.70
Myelin	activates	entity	0.70
MYELIN	associated_with	concept	0.50
MYELIN	interacts_with	concept	0.50
disease	interacts_with	disease	0.50
Myelination	inhibits	pathway	0.50
MYELIN	inhibits	concept	0.50
Myelination	associated_with	pathway	0.50
REMYELINATION	associated_with	concept	0.50
Myelination	expressed_in	pathway	0.50
disease	expressed_in	disease	0.50
NEURONS	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
OLIGODENDROCYTES	expressed_in	concept	0.50
DEMYELINATION	expressed_in	concept	0.50
DEMYELINATION	activates	concept	0.50
Psoriasis	activates	disease	0.50
MYELIN	expressed_in	concept	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
GLUCOSE METABOLISM	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
ISCHEMIC	associated_with	concept	0.50
Myelination	regulates	pathway	0.50
MYELIN	regulates	concept	0.50
CELL PROLIFERATION	regulates	concept	0.50
DISEASE-ASSOCIATED MICROGLIA	interacts_with	concept	0.50
NEURONS	associated_with	concept	0.50
DEMYELINATION	associated_with	concept	0.50
White Matter	activates	process	0.50
CELL DEATH	activates	concept	0.50
OLIGODENDROCYTES	activates	concept	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
REMYELINATION	activates	concept	0.50
MYELIN	activates	concept	0.50

Incoming (890)

Source	Relation	Type	Str
Multiple Sclerosis	causes	disease	0.90
Multiple Sclerosis	downregulates	disease	0.90
Ferroptosis	expressed_in	process	0.90
APOE4	expressed_in	gene	0.88
IGF1	promotes	protein	0.88
Microglia	interacts_with	cell_type	0.85
Cholesterol Metabolism	expressed_in	pathway	0.85
Α-SYNUCLEIN	expressed_in	protein	0.80
SERPINA3N	expressed_in	gene	0.75
ASTROCYTE	causes	gene	0.60
COMPLEMENT	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
CD19	therapeutic_target	gene	0.60
AQP4	causes	gene	0.60
AQP4	associated_with	gene	0.60
MYELIN	associated_with	gene	0.60
AQUAPORIN-4	associated_with	gene	0.60
STROKE	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
RNA	therapeutic_target	gene	0.60
TFR1	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
MALAT1	therapeutic_target	gene	0.60
MYELIN	inhibits	gene	0.60
RNA	regulates	gene	0.60
GPR37	inhibits	gene	0.60
PSAP	activates	gene	0.60
NEURON	activates	gene	0.60
PARKINSON	activates	gene	0.60
GPR37	activates	gene	0.60
STROKE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
BANG	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
CYTOKINES	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
GPR37	regulates	gene	0.60
ASTROCYTE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
RNA	associated_with	gene	0.60
JUN	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
C4B	associated_with	gene	0.60
PARKINSON	biomarker_for	gene	0.60

Targeting Hypotheses (17)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.632	neuroinflammation	How do oligodendrocytes initiate neuroin
Oligodendrocyte Precursor Cell Senescence in White Matter Di	0.600	-	Senescent cell clearance as neurodegener
PDE4 Inhibition as Inflammatory Reset for PD Oligodendrocyte	0.576	neuroinflammation	How do oligodendrocytes initiate neuroin
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive	0.512	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
White Matter Oligodendrocyte Protection via CXCL10 Inhibitio	0.480	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte Remyelination Enhancement	0.474	neurodegeneration	Gene expression changes in aging mouse b
White Matter Vulnerability Prevention via Oligodendrocyte Pr	0.468	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte DNA Repair Enhancement Therapy	0.462	neurodegeneration	Cell type vulnerability in Alzheimer's D
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.454	neurodegeneration	Cell type vulnerability in Alzheimer's D
TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocy	0.452	neuroscience	Circuit-level neural dynamics in neurode
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution	0.447	neurodegeneration	Neuroinflammation resolution mechanisms
Oligodendrocyte-Targeted Myelin Sulfatide Restoration Therap	0.434	neurodegeneration	Which cell types show the most significa
Oligodendrocyte Progenitor Cell Metabolic Reprogramming	0.410	neurodegeneration	Which cell types show the most significa
Oligodendrocyte White Matter Vulnerability	0.398	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte DNA Repair Enhancement	0.378	neurodegeneration	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (13)

Scientific analyses that reference this entity

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.505

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632

What specific gene expression signatures in aging mouse white matter predict hum

neurodegeneration | 2026-04-11 | 0 hypotheses

Is myelin loss in AD causal or an adaptive response to neuronal damage?

neurodegeneration | 2026-04-11 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934]	Sun Y, Ren Z, Ge J, Zhang W, Shao F et a	Biochim Biophys Acta Mol Basis	2026
IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095]	Peng M, Shu D, Chen Z, Yang Z, Zhang M e	J Neuroinflammation	2026
Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814]	Zhang X, Xue J, Zhao C, Zeng C, Zhong J	J Clin Invest	2026
Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028]	Yu D, Kang J, Jiang W, Zhang C, Zhao X e	Neuropharmacology	2026
Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614]	Li Z, Tan B, Dong K, Yu X, Zhang SW et a	Biochem Pharmacol	2026
Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873]	Main BS, Villapol S, Buenaventura RG, Ha	Brain Behav Immun	2026
Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781]	Bruna-Jara B, More J, Lobos P, Ponce DP,	Scientific reports	2026
Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505]	Ghosh S, Li X, Rawat K, Dighal A, Kalino	Nat Immunol	2026
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as [PMID:41941036]	Lai Y, Lin P, Zhang K, Hong W, Zheng M e	Cell Biol Toxicol	2026
Primary Infection with Cystoisospora suis Modulates Systemic Immunity and the Gu [PMID:41942044]	Ye X, Huang YJ, Deng XL, He ZY, Tan JJ e	Int J Parasitol	2026
Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408]	Tian X, Liu J, Li Y, Wang Y, Luo Y, He H	Nature	2026
HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707]	da Silva MTT, Araujo AQC	Brain : a journal of neurology	2026
Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603]	Ye L, Zhao T, Tian H, Li R, Li Z et al.	Sci China Life Sci	2026
The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805]	Nie W, Wang M, Cheng M, Ren Z, Liu G et	J Ethnopharmacol	2026
Elucidating the biological characteristics of overweight populations based on ur [PMID:41529508]	Li Y, Miao Y, Liang H, Zhou K, Li R et a	Spectrochim Acta A Mol Biomol	2026
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting [PMID:41799958]	Wu W, Cheng Z, Shi P, Gao H, Chen X et a	Bioact Mater	2026
Genetic Variation in the Chemokine Network and Atherosclerosis Risk. [PMID:41824188]	Zangas P, Georgakis MK	Curr Atheroscler Rep	2026
Early repetitive transcranial magnetic stimulation for preventing chronic postop [PMID:41943114]	Zhou WW, Yang Z, Zhou C, Qiao Q, Zhang Y	BMC Med	2026
cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activat [PMID:41495583]	["Li Xinyu", "Ding Huamin", "Qian Shuyu"	Inflammation	2026
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026

Oligodendrocyte

Understanding Entity Pages

Wiki Pages (21)