Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about COGNITION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | COGNITION |
| Summary | Coverage of AAIC 2026 sessions on vascular dementia, cerebral small vessel disease, blood-brain barrier dysfunction, and vascular contributions to Alzheimer's disease |
| Key Genes/Proteins | BDNF, CYP46A1 |
| Related Diseases | STROKE |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
COGNITION["COGNITION"]
COGNITION -->|"interacts"| Prefrontal_Cortex["Prefrontal Cortex"]
APOE4["APOE4"] -->|"inhibits"| COGNITION
Gut_Microbiota["Gut Microbiota"] -->|"modulates"| COGNITION
Dopaminergic_Circuits["Dopaminergic Circuits"] -->|"regulates"| COGNITION
LCPUFA_Supplementation["LCPUFA Supplementation"] -.protects against.-> COGNITION
BDNF["BDNF"] -->|"mediates"| COGNITION
Dentate_Gyrus["Dentate Gyrus"] -->|"involved_in"| COGNITION
Caffeine["Caffeine"] -->|"modulates"| COGNITION
ADENOSINE_RECEPTORS["ADENOSINE RECEPTORS"] -->|"regulates"| COGNITION| Target | Relation | Type | Str |
|---|---|---|---|
| Prefrontal Cortex | associated_with | entity | 0.70 |
| Prefrontal Cortex | interacts_with | entity | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-SYK Signaling Axis Couples OxPC Recognition to Phagocy | 0.505 | neuroinflammation | What molecular mechanisms enable microgl |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||