gene

CSNK2A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSNK2A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

24Outgoing

14Incoming

0Experiments

Summary

Page for CSNK2A2 Gene

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🧬 Gene Info

Gene Symbol	CSNK2A2
Chromosome	16p13.3
Function	### CK2 Holoenzyme Composition
Amino Acids	350 aa
Exons	12
Pathways	Mitophagy, Cgas-Sting, autophagy pathway
Ensembl ID	ENSG00000070770
GeneCards	CSNK2A2
Human Protein Atlas	CSNK2A2
High homology	90% identical to CK2α in the catalytic domain
Distinct C-terminus	Different from CK2α, contributing to unique substrate specificity
Tissue-specific expression	More restricted pattern than CSNK2A1
α'₂β₂	Homotetramer with two α' catalytic subunits
αα'β₂	Heterotetramer mixing α and α' subunits
Substrate differences	Some substrates preferentially phosphorylated by α' vs α
Associated Diseases	Ischemia
KG Connections	38 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CSNK2A2["CSNK2A2"]
    Ischemia["Ischemia"]
    ULK1["ULK1"]
    VDAC1["VDAC1"]
    FUNDC1["FUNDC1"]
    Mitophagy["Mitophagy"]
    Endothelial["Endothelial"]
    Macrophage["Macrophage"]
    T_Cell["T Cell"]
    MITOPHAGY["MITOPHAGY"]
    MFN2["MFN2"]
    UBC["UBC"]
    MITOCHONDRIA["MITOCHONDRIA"]
    MAP1LC3B["MAP1LC3B"]
    PINK1["PINK1"]
    RNA["RNA"]
    CGAS_STING["CGAS-STING"]
    neurodegeneration["neurodegeneration"]
    CSNK2A2 -.-|"associated"| Ischemia
    CSNK2A2 -->|"regulates"| ULK1
    CSNK2A2 -->|"regulates"| VDAC1
    CSNK2A2 -->|"regulates"| FUNDC1
    CSNK2A2 -.-|"associated"| Mitophagy
    CSNK2A2 -.-|"associated"| Endothelial
    CSNK2A2 -.-|"associated"| Macrophage
    CSNK2A2 -.-|"associated"| T_Cell
    MITOPHAGY -.-|"associated"| CSNK2A2
    MFN2 -->|"regulates"| CSNK2A2
    UBC -->|"regulates"| CSNK2A2
    MITOCHONDRIA -.-|"associated"| CSNK2A2
    MAP1LC3B -->|"regulates"| CSNK2A2
    PINK1 -->|"regulates"| CSNK2A2
    RNA -.-|"associated"| CSNK2A2
    CGAS_STING -.-|"associated"| CSNK2A2
    CSNK2A2 -->|"implicated_in"| neurodegeneration
    style CSNK2A2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (24)

Target	Relation	Type	Str
Ischemia	associated_with	disease	0.65
ULK1	regulates	gene	0.60
VDAC1	regulates	gene	0.60
FUNDC1	regulates	gene	0.60
UBC	regulates	gene	0.60
MFN2	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
STING	associated_with	gene	0.60
PINK1	regulates	gene	0.60
Mitophagy	associated_with	pathway	0.60
Endothelial	associated_with	cell_type	0.60
Macrophage	associated_with	cell_type	0.60
T Cell	associated_with	cell_type	0.60
AND	regulates	gene	0.60
MITOPHAGY	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
RNA	associated_with	gene	0.60
CGAS-STING	associated_with	gene	0.60
Cgas-Sting	associated_with	pathway	0.60
Fus	associated_with	protein	0.60
autophagy pathway	participates_in	pathway	0.60
T Cell	expressed_in	cell_type	0.55
Endothelial Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55

Incoming (14)

Source	Relation	Type	Str
MFN2	regulates	gene	0.60
UBC	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
PINK1	regulates	gene	0.60
VDAC1	regulates	gene	0.60
CGAS	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
RNA	associated_with	gene	0.60
CGAS-STING	associated_with	gene	0.60
GENES	regulates	gene	0.60
MITOPHAGY-RELATED GENES	associated_with	gene	0.60
ULK1	regulates	gene	0.50
FUNDC1	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found