gene

UBC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

202Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

UBC is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, regulates. Associated with ALS, Aging, Als. Connected to 121 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	UBC
Aliases	Ubiquitin C
Chromosome	12q24.31
Protein Type	Enzyme
Function	is a highly conserved 76-amino acid protein that plays a central role in the ubiquitin-proteasome system (UPS) and lysosomal degradation pathways.
Molecular Weight	8.5 kDa
Amino Acids	76 aa
Pathways	NF-κB
GeneCards	UBC
Human Protein Atlas	UBC
Associated Diseases	ALS, Alzheimer, Cancer, Ischemia, Ms
Interactions	VCP, CTNNB1, EGFR, HSP90AA1, APP, MDM2
KG Connections	202 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    UBC["UBC"]
    UBC -->|"expressed in"| Alzheimer["Alzheimer"]
    UBC -->|"expressed in"| Aging["Aging"]
    UBC -->|"expressed in"| Als["Als"]
    UBC -->|"expressed in"| Ms["Ms"]
    UBC -->|"expressed in"| Dementia["Dementia"]
    UBC -->|"expressed in"| Lymphoma["Lymphoma"]
    UBC -->|"expressed in"| Cancer["Cancer"]
    UBC -->|"expressed in"| Tumor["Tumor"]
    UBC -->|"expressed in"| CELF2["CELF2"]
    UBC -->|"expressed in"| JUN["JUN"]
    FYN["FYN"] -->|"expressed in"| UBC
    AGING["AGING"] -->|"expressed in"| UBC
    VCP["VCP"] -->|"interacts"| UBC
    CTNNB1["CTNNB1"] -->|"interacts"| UBC
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| UBC
    EGFR["EGFR"] -->|"interacts"| UBC
    HSP90AA1["HSP90AA1"] -->|"interacts"| UBC
    APP["APP"] -->|"interacts"| UBC
    HSP90AB1["HSP90AB1"] -->|"expressed in"| UBC
    MDM2["MDM2"] -->|"interacts"| UBC

Outgoing (116)

Target	Relation	Type	Str
GFAP	coexpressed_with	protein	0.80
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Lymphoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Osteoarthritis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	biomarker_for	disease	0.65
Cancer	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Ischemia	associated_with	disease	0.65
Stroke	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	activates	disease	0.65
HOMER1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
ATG3	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
SCA3	associated_with	gene	0.60
ATG12	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
CELF2	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
FYN	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
SRC	associated_with	gene	0.60

Incoming (86)

Source	Relation	Type	Str
DRD2	associated_with	gene	0.60
FYN	associated_with	gene	0.60
SRC	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
COMT	associated_with	gene	0.60
HOMER1	associated_with	gene	0.60
CYCS	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
P62	associated_with	gene	0.60
SLC6A3	co_discussed	gene	0.60
SNCA	co_discussed	gene	0.60
FYN	expressed_in	gene	0.60
VCP	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
HSP90AA1	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
HSP90AB1	expressed_in	gene	0.60
MDM2	interacts_with	gene	0.60
HSF1	expressed_in	gene	0.60
GRB2	interacts_with	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
ATG3	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
SCA3	associated_with	gene	0.60
CSNK2B	regulates	gene	0.60
TOMM20	therapeutic_target	gene	0.60
UBB	regulates	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
MFN2	regulates	gene	0.60
CLDN5	regulates	gene	0.60
VDAC1	regulates	gene	0.60
CGAS	associated_with	gene	0.60
PINK1	regulates	gene	0.60
CSNK2A2	regulates	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
SDHA	regulates	gene	0.60
ULK1	regulates	gene	0.60
OCLN	regulates	gene	0.60
ZO1	regulates	gene	0.60
FUNDC1	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
MAP1LC3B	co_discussed	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
YWHAG-Mediated TFEB Subcellular Targeting	0.382	neurodegeneration	Does TFEB dysfunction cause neurodegener

Mentioning Analyses (2)

Scientific analyses that reference this entity

How can subcellular compartmentalization defects be measured as biomarkers in li

neuroscience | 2026-04-10 | 0 hypotheses

How do protein-protein interactions determine subcellular localization and funct

synaptic biology | 2026-04-08 | 0 hypotheses

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026	0
Charting the research frontier for viral infections, immunomodulation, and demen [PMID:41561087]	Lee CK, Woodward M, Hohenberg MI, Tang J	Front Cell Infect Microbiol	2025	0

UBC

Understanding Entity Pages

Summary

Wiki Pages (21)

UBC

UBE2V1 Gene (UEV-1)

TRIM2 Gene (Tripartite Motif Containing 2)

University of British Columbia

UBE2I Protein

Autophagy Enhancement Drug Screening for Neurodegeneration

Proteasomal Pathway in Neurodegeneration

UBC Protein

SCA3 — ATXN3 (Ataxin-3)

Chaperone-Mediated Proteostasis in 4R-Tauopathies

University of British Columbia

Frontotemporal Dementia Knowledge Gaps

UBE2V2 Protein

Canadian Neurodegeneration Biotech Companies

Medial Geniculate Nucleus Neurons

UBE2A Gene

STRADA Gene

Unipolar Brush Cells

UBE2A Protein

Ubiquitin Protein

Cerebellar Nodulus Neurons