pathway

Cgas-Sting

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cgas-Sting: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1561Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Cgas-Sting
Related Diseases	PARKINSON'S DISEASE, ALS, ALZHEIMER'S DISEASE, AGING
Related Pathways	Intracellular Dna Sensing

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INFLAMMATION["INFLAMMATION"] -->|"therapeutic target"| Cgas_Sting["Cgas-Sting"]
    CGAS["CGAS"] -->|"activates"| Cgas_Sting["Cgas-Sting"]
    DSDNA["DSDNA"] -->|"activates"| Cgas_Sting["Cgas-Sting"]
    AND["AND"] -->|"activates"| Cgas_Sting["Cgas-Sting"]
    style Cgas_Sting fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (714)

Target	Relation	Type	Str
Neuroinflammation	associated_with	process	0.95
Neurodegeneration	associated_with	process	0.95
NEUROINFLAMMATION	mediates	process	0.92
Type I Interferon Response	activates	process	0.91
NEURODEGENERATION	involved_in	process	0.90
Immune Response	involved_in	process	0.90
PARKINSON'S DISEASE	contributes_to	disease	0.90
ALS	contributes_to	disease	0.90
Intracellular Dna Sensing	mediates	mechanism	0.90
Ectopic Dna Detection	involved_in	process	0.90
ALZHEIMER'S DISEASE	involved_in	disease	0.88
PARKINSON'S DISEASE	involved_in	disease	0.88
ALS	involved_in	disease	0.88
AGING	involved_in	phenotype	0.87
DNA	associated_with	entity	0.85
ALZHEIMER'S DISEASE	modulates	disease	0.85
MICROGLIA	involved_in	cell_type	0.78
NEURON	involved_in	cell_type	0.78
ASTROCYTES	involved_in	cell_type	0.78
Astrocytes	activates	cell_type	0.75
Neuron	modulates	cell_type	0.75
Macrophage	activates	cell_type	0.50
Interferon Signaling	activates	pathway	0.50
cGAS-STING pathway	activates	pathway	0.50
disease	associated_with	disease	0.50
NEURONS	associated_with	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
Tau Phosphorylation	causes	pathway	0.50
disease	causes	disease	0.50
cGAS-STING pathway	causes	pathway	0.50
cGAS-STING pathway	associated_with	pathway	0.50
Ataxia	activates	disease	0.50
disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50
HUNTINGTON'S DISEASE	interacts_with	concept	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
HUNTINGTON'S	interacts_with	concept	0.50
cGAS-STING pathway	interacts_with	pathway	0.50
cGAS-STING pathway	regulates	pathway	0.50
Neuroinflammatory	activates	pathway	0.50
cGAS-STING pathway	inhibits	pathway	0.50
Immunotherapy	activates	process	0.50
PD-L1	activates	concept	0.50
NEURONS	activates	concept	0.50
PARKINSON'S	associated_with	concept	0.50
Macrophage	inhibits	cell_type	0.50
LYSOSOME	activates	gene	0.50
LYSOSOME	regulates	gene	0.50
Neuroprotection	inhibits	process	0.50

Incoming (847)

Source	Relation	Type	Str
Cgas Inhibitors	inhibits	drug	0.85
INFLAMMATION	therapeutic_target	gene	0.60
CGAS	activates	gene	0.60
DSDNA	activates	gene	0.60
AND	activates	gene	0.60
STAT3	activates	gene	0.60
STING	activates	gene	0.60
CGAS-STING	activates	gene	0.60
IL6	activates	gene	0.60
IL-6	activates	gene	0.60
CGAS	regulates	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	regulates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
AND	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
YY1	regulates	gene	0.60
GENES	activates	gene	0.60
STING	regulates	gene	0.60
CGAS-STING	regulates	gene	0.60
LYSOSOME	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
RAS	activates	gene	0.60
FLCN	activates	gene	0.60
MTORC1	activates	gene	0.60
GABARAP	activates	gene	0.60
TFEB	activates	gene	0.60
MITF	activates	gene	0.60
TFE3	activates	gene	0.60
DNA	activates	gene	0.60
TBK1	activates	gene	0.60
MTOR	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
MTDNA	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
ROS	activates	gene	0.60
CANCER	activates	gene	0.60
ATP	activates	gene	0.60
DRP1	activates	gene	0.60
LC3B	activates	gene	0.60
CGAS	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60
IRF3	activates	gene	0.60
STING	inhibits	gene	0.60
CGAS-STING	inhibits	gene	0.60
IFN	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ATG16L1	activates	gene	0.60
EXTRANUCLEAR CHROMATIN	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
cGAS-STING Senescence Circuit Disruption	0.486	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960]	Fazal F, Dar NJ, Ahamad S, Khan S, Bano	Mol Aspects Med	2026
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397]	Lu C, Wang W, Fu YX	Nat Rev Cancer	2026
Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200]	Li D, Cui G, Yang K, Lu C, Jiang Y et al	Nat Cell Biol	2026
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413]	Solomon J, Mandal S, Aran KR	Gene	2026
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867]	Li L, Ye Q, Ma J, Wang Z, Liu T et al.	Cancer Cell	2026
DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic [PMID:41610251]	Tomaskovic I, Prieto-Garcia C, Boskovic	Science	2026
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026
EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and pr [PMID:41738749]	Zhang Q, Abudukadier A, Chen H, Xiong L,	Microbiol Spectr	2026
Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243]	Zhang M, Lan Y, Yue Q, He J, Li L et al.	J Nanobiotechnology	2026
STING-NF-κB signaling builds an influenza spillover barrier. [PMID:41747053]	Ye R, Wang S, Hu Y, Pan Y, Zheng W et al	Science	2026
Development of UM-200: A Novel Alkyne Amide-Based Inhibitor of the cGAS-STING Pa [PMID:41866990]	Barasa L, DeOrsey L, O'Reilly MD, Choudh	J Med Chem	2026
Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STIN [PMID:41910318]	Yang LM, Lu Y, Levine MS, Wang X, Shi YQ	J Am Chem Soc	2026
African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral [PMID:41937559]	Li X, Ren B, Zhang D, Dan M, Liu D et al	Autophagy	2026
Microvesicle release drives cycles of mitophagy flux disruption and inflammatory [PMID:41941625]	Song R, Ma Y, Wan J, Hao S, Chen B et al	Proc Natl Acad Sci U S A	2026

Cgas-Sting

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Alzheimer's Disease Mechanism Index

neuroinflammation

metal-ion-synuclein-mitochondria-axis-parkinsons

Neuroinflammation-Mitochondria Crosstalk Pathway

mitophagy-defect

DNA Damage Response Impairment Pathway

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Necroptotic Neurons

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Vestibular Function Testing in Corticobasal Syndrome

TGF-β Signaling in Parkinson's Disease

Lipid Metabolism Dysregulation in Neurodegeneration

PBKR03

Portable Driving Simulator for PD Assessment (NCT03969927)

Epigenetic Mechanisms in Alzheimer's Disease

cGAS-STING Signaling in Parkinson's Disease

Mitochondria in Neurodegeneration