Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DAG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DAG1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in, therapeutic target. Associated with AD, ALS, Als. Connected to 22 entities in the SciDEX knowledge graph.
| Gene Symbol | DAG1 |
| Full Name | Dystroglycan 1 |
| Chromosome | 3p21.31 |
| Function | Dystroglycan is a core component of the dystrophin-glycoprotein complex (DGC) |
| Molecular Weight | α-DG: ~156 kDa; β-DG: ~43 kDa |
| Exons | 2 |
| Pathways | Toll-Like Receptor |
| UniProt ID | Q07421 |
| NCBI Gene ID | 1745 |
| Ensembl ID | ENSG00000173402 |
| OMIM | 128239 |
| GeneCards | DAG1 |
| Human Protein Atlas | DAG1 |
| Protein Name | Dystroglycan (α and β subunits) |
| Approach | Status |
| Associated Diseases | AD, ALS, LOAD, Muscular Dystrophy, RA |
| Interactions | TOLL, DYSTROGLYCAN, BCL-2, RNA |
| KG Connections | 50 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DAG1["<b>DAG1</b>"]
Als{"Als"}
DAG1 -->|"therapeutic target"| Als
Fibrosis{"Fibrosis"}
DAG1 -->|"regulates"| Fibrosis
DAG1 -->|"inhibits"| Als
ALS{"ALS"}
DAG1 -->|"regulates"| ALS
BAD["BAD"]
DAG1 -->|"regulates"| BAD
HSPG2["HSPG2"]
DAG1 -->|"regulates"| HSPG2
BCL_2["BCL-2"]
DAG1 -->|"regulates"| BCL_2
IGF1R["IGF1R"]
DAG1 -->|"regulates"| IGF1R
Toll_Like_Receptor(["Toll-Like Receptor"])
DAG1 -->|"regulates"| Toll_Like_Receptor
Fibroblast["Fibroblast"]
DAG1 -->|"expressed in"| Fibroblast
AD{"AD"}
DAG1 -->|"implicated in"| AD
DAG1 -->|"implicated in"| Als
HSPG2 -->|"regulates"| DAG1
IGF1R -->|"regulates"| DAG1
BCL_2 -->|"regulates"| DAG1
ROS["ROS"]
ROS -->|"regulates"| DAG1
BAD -->|"regulates"| DAG1
AND["AND"]
AND -->|"regulates"| DAG1
style DAG1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Yap | binds | protein | 0.80 |
| POMGnT1 | interacts_with | enzyme | 0.80 |
| Muscular Dystrophy | associated_with | disease | 0.80 |
| Cardiomyocyte Proliferation | inhibits | biological_process | 0.80 |
| Glycosylation | participates_in | biological_process | 0.70 |
| Als | therapeutic_target | disease | 0.65 |
| Fibrosis | regulates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| BAD | regulates | gene | 0.60 |
| HSPG2 | regulates | gene | 0.60 |
| IGF1R | regulates | gene | 0.60 |
| HSPG2 | activates | entity | 0.60 |
| IGF1R | activates | entity | 0.60 |
| TOLL | activates | gene | 0.60 |
| BCL-2 | regulates | gene | 0.60 |
| Toll-Like Receptor | regulates | pathway | 0.60 |
| ROS | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| Fibroblast | regulates | cell_type | 0.60 |
| Insulin | regulates | protein | 0.60 |
| Interleukin | regulates | protein | 0.60 |
| Metalloproteinase | therapeutic_target | protein | 0.60 |
| Igf | regulates | protein | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| RNA | activates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Fibroblast | expressed_in | cell_type | 0.55 |
| fibrosis | implicated_in | disease | 0.50 |
| LOAD | implicated_in | disease | 0.50 |
| IGF1R | co_expressed_with | gene | 0.50 |
| AD | implicated_in | disease | 0.50 |
| Als | implicated_in | disease | 0.50 |
| RA | implicated_in | disease | 0.50 |
| SS | implicated_in | disease | 0.50 |
| DYSTROGLYCAN | activates | protein | 0.50 |
| FIBROSIS | activates | disease | 0.50 |
| BCL-2 | activates | protein | 0.50 |
| INSULIN | activates | concept | 0.50 |
| FIBROBLASTS | activates | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||