gene

DAG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections
0Hypotheses
0Analyses
42Outgoing
8Incoming

Summary

DAG1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, implicated in, therapeutic target. Associated with AD, ALS, Als. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDAG1
Full NameDystroglycan 1
Chromosome3p21.31
FunctionDystroglycan is a core component of the dystrophin-glycoprotein complex (DGC)
Molecular Weightα-DG: ~156 kDa; β-DG: ~43 kDa
Exons2
PathwaysToll-Like Receptor
UniProt IDQ07421
NCBI Gene ID1745
Ensembl IDENSG00000173402
OMIM128239
GeneCardsDAG1
Human Protein AtlasDAG1
Protein NameDystroglycan (α and β subunits)
ApproachStatus
Associated DiseasesAD, ALS, LOAD, Muscular Dystrophy, RA
InteractionsTOLL, DYSTROGLYCAN, BCL-2, RNA
KG Connections50 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: DAG1 — AlphaFold Q07421 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

DAG1 Gene

gene · 799 words

Dystroglycan Protein

protein · 1745 words

POMT2

gene · 1745 words

Collagen IV Alpha-2 Chain Protein

protein · 1359 words

Neurexin-1 Protein (NRXN1)

protein · 1106 words

CAV3

gene · 960 words

Pathway Diagram

graph TD
    DAG1["<b>DAG1</b>"]
    Als{"Als"}
    DAG1 -->|"therapeutic target"| Als
    Fibrosis{"Fibrosis"}
    DAG1 -->|"regulates"| Fibrosis
    DAG1 -->|"inhibits"| Als
    ALS{"ALS"}
    DAG1 -->|"regulates"| ALS
    BAD["BAD"]
    DAG1 -->|"regulates"| BAD
    HSPG2["HSPG2"]
    DAG1 -->|"regulates"| HSPG2
    BCL_2["BCL-2"]
    DAG1 -->|"regulates"| BCL_2
    IGF1R["IGF1R"]
    DAG1 -->|"regulates"| IGF1R
    Toll_Like_Receptor(["Toll-Like Receptor"])
    DAG1 -->|"regulates"| Toll_Like_Receptor
    Fibroblast["Fibroblast"]
    DAG1 -->|"expressed in"| Fibroblast
    AD{"AD"}
    DAG1 -->|"implicated in"| AD
    DAG1 -->|"implicated in"| Als
    HSPG2 -->|"regulates"| DAG1
    IGF1R -->|"regulates"| DAG1
    BCL_2 -->|"regulates"| DAG1
    ROS["ROS"]
    ROS -->|"regulates"| DAG1
    BAD -->|"regulates"| DAG1
    AND["AND"]
    AND -->|"regulates"| DAG1
    style DAG1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

TargetRelationTypeStr
Yapbindsprotein0.80
POMGnT1interacts_withenzyme0.80
Muscular Dystrophyassociated_withdisease0.80
Cardiomyocyte Proliferationinhibitsbiological_process0.80
Glycosylationparticipates_inbiological_process0.70

Incoming (8)

SourceRelationTypeStr
HSPG2regulatesgene0.60
IGF1Rregulatesgene0.60
BADregulatesgene0.60
BADactivatesentity0.60
BCL-2regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found