gene

DR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

23Outgoing

10Incoming

Summary

DRD3 — Dopamine Receptor D3

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🧬 Gene Info

Gene Symbol	DRD3
Full Name	Dopamine Receptor D3
Chromosome	3q13.31
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the limbic system and plays critical roles in reward, motivation, and movement control
Molecular Weight	130 kDa
Pathways	MAPK, PI3K
UniProt ID	P35462
NCBI Gene ID	1818
Ensembl ID	ENSG00000151577
OMIM	139251
GeneCards	DRD3
Human Protein Atlas	DRD3
Associated Diseases	neurodegeneration
Known Drugs/Compounds	D-520
Interactions	ULK1, DRD2, AMPK
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DR3["DR3"]
    Lupus{"Lupus"}
    DR3 -->|"associated_with"| Lupus
    Als{"Als"}
    DR3 -->|"associated_with"| Als
    Hepatitis{"Hepatitis"}
    DR3 -->|"associated_with"| Hepatitis
    Inflammation{"Inflammation"}
    DR3 -->|"associated_with"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    DR3 -->|"activates"| Neuroinflammation
    Alzheimer{"Alzheimer"}
    DR3 -->|"activates"| Alzheimer
    Aging{"Aging"}
    DR3 -->|"activates"| Aging
    DR3 -->|"activates"| Inflammation
    AND["AND"]
    DR3 -->|"associated_with"| AND
    EGF["EGF"]
    DR3 -->|"associated_with"| EGF
    NF_B["NF-KappaB"]
    DR3 -->|"activates"| NF_B
    INFLAMMATION["INFLAMMATION"]
    DR3 -->|"activates"| INFLAMMATION
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    DR3 -->|"activates"| NEUROINFLAMMATION
    Oxidative_Stress(["Oxidative Stress"])
    DR3 -->|"activates"| Oxidative_Stress
    Nf_b(["Nf-Kappab"])
    DR3 -->|"activates"| Nf_b

Outgoing (23)

Target	Relation	Type	Str
Lupus	associated_with	disease	0.65
Als	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
EGF	associated_with	gene	0.60
TAU	activates	gene	0.60
neuroinflammation	activates	disease	0.60
AND	associated_with	gene	0.60
NF-ΚB	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
AND	activates	gene	0.60
AGING	activates	gene	0.60
NF-kB signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
IKK	inhibits	gene	0.60
IKK	activates	gene	0.60

Incoming (10)

Source	Relation	Type	Str
TAU	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
AGING	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DR3