Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ELMO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ELMO1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Infection, Inflammation. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | ELMO1 |
| Full Name | Engulfment and Cell Motility 1 |
| Aliases | Page for ELMO1, Page for ELMO1 Protein |
| Chromosome | 7p14.3 |
| Function | Apoptotic Cell Clearance: ELMO1 mediates the recognition and engulfment of apoptotic cells by phagocytes [2] |
| Primary Expression | Microglia, Macrophages, Brain, Immune cells |
| Molecular Weight | 85 kDa |
| Pathways | Autophagy |
| UniProt ID | Q9Y6I4 |
| NCBI Gene ID | 2004 |
| Ensembl ID | ENSG00000126603 |
| OMIM | 606520 |
| GeneCards | ELMO1 |
| Human Protein Atlas | ELMO1 |
| Symbol [@hochreiterhufford2013] ELMO1 [@martinez2019] [@brahma2016] Full Name | Engulfment and Cell Motility 1 |
| Associated Diseases | Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis |
| Interactions | LC3, LC3B, AUTOPHAGY |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ELMO1["<b>ELMO1</b>"]
Infection{"Infection"}
ELMO1 -->|"regulates"| Infection
Inflammation{"Inflammation"}
ELMO1 -->|"regulates"| Inflammation
LYSOSOME(["LYSOSOME"])
ELMO1 -->|"associated_with"| LYSOSOME
INFLAMMATION(["INFLAMMATION"])
ELMO1 -->|"regulates"| INFLAMMATION
LC3(["LC3"])
ELMO1 -->|"activates"| LC3
LC3B(["LC3B"])
ELMO1 -->|"activates"| LC3B
ATG5(["ATG5"])
ATG5 -->|"regulates"| ELMO1
style ELMO1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Infection | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| LC3 | activates | gene | 0.60 |
| ULK1 | regulates | gene | 0.60 |
| LYSOSOME | associated_with | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| PHAGOCYTOSIS | associated_with | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Phagocytosis | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ATG5 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity