gene

ERCC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERCC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections
0Hypotheses
0Analyses
29Outgoing
8Incoming

Summary

Page for ERCC2 Gene - Excision Repair Cross-Complementation Group 2

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🧬 Gene Info
Gene SymbolERCC2
Full NameExcision Repair Cross-Complementation Group 2
AliasesPage for ERCC2 Gene, Page for ERCC2 Protein (XPD)
Chromosome19q13.32
Protein TypeTranscription Factor
FunctionIt functions as the 5' to 3' helicase subunit within the TFIIH complex (Core TFIIH).
Molecular Weight87 kDa
Amino Acids760 aa
UniProt IDP18080
NCBI Gene ID2075
Ensembl IDENSG00000104881
OMIM278720
GeneCardsERCC2
Human Protein AtlasERCC2
Associated DiseasesALS, Alzheimer
InteractionsCANCER
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: ERCC2 — AlphaFold P18080 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

ERCC2 Gene - Excision Repair Cross-Complementation Group 2

gene · 652 words

GTF2H4 (General Transcription Factor IIH Subunit 4)

gene · 2548 words

ERCC5 (XPG) Gene — Excision Repair Cross-Complementation Group 5

gene · 1930 words

GTF2H3 Protein

protein · 1782 words

GTF2H2 Gene

gene · 1688 words

ERCC2 Protein (XPD) - DNA Repair Helicase

protein · 753 words

Pathway Diagram

graph TD
    ERCC2["<b>ERCC2</b>"]
    Als{"Als"}
    ERCC2 -->|"associated with"| Als
    Cancer{"Cancer"}
    ERCC2 -->|"activates"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    ERCC2 -->|"contributes to"| Neurodegeneration
    CANCER["CANCER"]
    ERCC2 -->|"activates"| CANCER
    AUTOPHAGY["AUTOPHAGY"]
    ERCC2 -->|"contributes to"| AUTOPHAGY
    Autophagy(["Autophagy"])
    ERCC2 -->|"contributes to"| Autophagy
    neurodegeneration["neurodegeneration"]
    ERCC2 -->|"implicated in"| neurodegeneration
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"contributes to"| ERCC2
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"contributes to"| ERCC2
    NBR1["NBR1"]
    NBR1 -->|"associated with"| ERCC2
    style ERCC2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

TargetRelationTypeStr
Alsassociated_withdisease0.65
Canceractivatesdisease0.65
Neurodegenerationcontributes_todisease0.65
Alzheimerassociated_withdisease0.65
Alsexpressed_indisease0.65

Incoming (8)

SourceRelationTypeStr
UBIQUITINcontributes_togene0.60
NBR1associated_withgene0.60
APOEassociated_withgene0.60
NEURODEGENERATIONcontributes_togene0.60
APOPTOSISassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found