Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ERCC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | ERCC2 |
| Full Name | Excision Repair Cross-Complementation Group 2 |
| Aliases | Page for ERCC2 Gene, Page for ERCC2 Protein (XPD) |
| Chromosome | 19q13.32 |
| Protein Type | Transcription Factor |
| Function | It functions as the 5' to 3' helicase subunit within the TFIIH complex (Core TFIIH). |
| Molecular Weight | 87 kDa |
| Amino Acids | 760 aa |
| UniProt ID | P18080 |
| NCBI Gene ID | 2075 |
| Ensembl ID | ENSG00000104881 |
| OMIM | 278720 |
| GeneCards | ERCC2 |
| Human Protein Atlas | ERCC2 |
| Associated Diseases | ALS, Alzheimer |
| Interactions | CANCER |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ERCC2["<b>ERCC2</b>"]
Als{"Als"}
ERCC2 -->|"associated with"| Als
Cancer{"Cancer"}
ERCC2 -->|"activates"| Cancer
Neurodegeneration{"Neurodegeneration"}
ERCC2 -->|"contributes to"| Neurodegeneration
CANCER["CANCER"]
ERCC2 -->|"activates"| CANCER
AUTOPHAGY["AUTOPHAGY"]
ERCC2 -->|"contributes to"| AUTOPHAGY
Autophagy(["Autophagy"])
ERCC2 -->|"contributes to"| Autophagy
neurodegeneration["neurodegeneration"]
ERCC2 -->|"implicated in"| neurodegeneration
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"contributes to"| ERCC2
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"contributes to"| ERCC2
NBR1["NBR1"]
NBR1 -->|"associated with"| ERCC2
style ERCC2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Neurodegeneration | contributes_to | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Aging | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| APOE | associated_with | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| AUTOPHAGY | contributes_to | gene | 0.60 |
| Autophagy | contributes_to | pathway | 0.60 |
| Neurogenesis | associated_with | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| AMYLOID-BETA | associated_with | gene | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| Amyloid-Beta | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| Ras | associated_with | protein | 0.60 |
| hippocampus | expressed_in | brain_region | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| UBIQUITIN | contributes_to | gene | 0.60 |
| NBR1 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| NEURODEGENERATION | contributes_to | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AMYLOID-BETA | associated_with | gene | 0.60 |
| APOE | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||