gene

FLNC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FLNC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

31Outgoing

16Incoming

0Experiments

Summary

Comprehensive page on FLNC (Filamin C), an actin-crosslinking protein essential for sarcomere integrity and implicated in myofibrillar myopathy, cardiomyopathy, and ALS.

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🧬 Gene Info

Gene Symbol	FLNC
Aliases	Filamin C
Chromosome	7q32.1
Function	is a large actin-binding protein that plays essential roles in maintaining the structural integrity of skeletal and cardiac muscle.
Primary Expression	skeletal and cardiac muscle, with lower levels detected in some other tissues
Molecular Weight	291 kDa
Amino Acids	632 aa
Exons	48
Pathways	ubiquitin-proteasome
Ensembl ID	ENSG00000128591
GeneCards	FLNC
Human Protein Atlas	FLNC
Skeletal Muscle	Very high expression in all major skeletal muscle groups, concentrated at the Z-disc and myotendinous junctions.
Cardiac Muscle	High expression in both ventricular and atrial myocardium, particularly in the left ventricle.
Smooth Muscle	Low expression in some smooth muscle populations.
Associated Diseases	Myofibrillar Myopathy
Interactions	MYOT, NBR1, P62, GENES, WAS
KG Connections	47 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FLNC["<b>FLNC</b>"]
    Myofibrillar_Myopathy{"Myofibrillar Myopathy"}
    FLNC -->|"causes"| Myofibrillar_Myopathy
    MYOT["MYOT"]
    FLNC -->|"degrades"| MYOT
    NBR1["NBR1"]
    FLNC -->|"degrades"| NBR1
    P62["P62"]
    FLNC -->|"degrades"| P62
    SQSTM1["SQSTM1"]
    FLNC -->|"degrades"| SQSTM1
    GENES(["GENES"])
    FLNC -->|"activates"| GENES
    BRCA1["BRCA1"]
    BRCA1 -->|"degrades"| FLNC
    DES["DES"]
    DES -->|"degrades"| FLNC
    DNAJB6["DNAJB6"]
    DNAJB6 -->|"degrades"| FLNC
    AUTOPHAGY(["AUTOPHAGY"])
    AUTOPHAGY -->|"co_discussed"| FLNC
    style FLNC fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (31)

Target	Relation	Type	Str
Myofibrillar Myopathy	causes	disease	0.95
MYOT	degrades	entity	0.60
NBR1	degrades	entity	0.60
P62	degrades	entity	0.60
SQSTM1	degrades	entity	0.60
NBR1	associated_with	gene	0.60
MYOT	associated_with	gene	0.60
P62	associated_with	gene	0.60
DES	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
DNAJB6	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AND	associated_with	gene	0.60
TTN	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Proteasome	associated_with	pathway	0.60
GENES	associated_with	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Ca1	expressed_in	brain_region	0.55
MYOT	activates	gene	0.50
NBR1	activates	gene	0.50
P62	activates	protein	0.50
SQSTM1	co_discussed	gene	0.50
STING	co_discussed	gene	0.50
UBIQUITIN	co_discussed	protein	0.50
GENES	activates	gene	0.50
P62/SQSTM1	co_discussed	protein	0.50
WAS	activates	protein	0.50
P62/SQSTM1	associated_with	protein	0.50
Proteins	associated_with	protein	0.50

Incoming (16)

Source	Relation	Type	Str
BRCA1	degrades	entity	0.60
DES	degrades	entity	0.60
DNAJB6	degrades	entity	0.60
DNAJB6	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
BRCA1	associated_with	gene	0.60
DES	associated_with	gene	0.60
P62	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
MYOT	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
BRCA1	co_discussed	protein	0.50
DES	co_discussed	gene	0.50
DNAJB6	co_discussed	gene	0.50
AUTOPHAGY	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FLNC

Understanding Entity Pages

Summary

Wiki Pages (5)

FLNC Gene

FLNC Protein

Filamin A (FLNA)

Proteins