DES

Understanding Entity Pages

This page aggregates everything SciDEX knows about DES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

DES is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, associated with. Associated with ALS, Aging, Als. Connected to 115 entities in the SciDEX knowledge graph.

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graph TD
    DES["<b>DES</b>"]
    SMOC2["SMOC2"]
    DES -->|"co expressed with"| SMOC2
    DSP["DSP"]
    DES -->|"co expressed with"| DSP
    GJA1["GJA1"]
    DES -->|"co expressed with"| GJA1
    myofibrillar_myopathy{"myofibrillar myopathy"}
    DES -->|"causes"| myofibrillar_myopathy
    Aging{"Aging"}
    DES -->|"activates"| Aging
    Ms{"Ms"}
    DES -->|"activates"| Ms
    Cancer{"Cancer"}
    DES -->|"associated with"| Cancer
    Als{"Als"}
    DES -->|"therapeutic target"| Als
    DES -->|"therapeutic target"| Aging
    Tumor{"Tumor"}
    DES -->|"therapeutic target"| Tumor
    Longevity{"Longevity"}
    DES -->|"therapeutic target"| Longevity
    DES -->|"associated with"| Ms
    MCU["MCU"]
    MCU -->|"activates"| DES
    SLC7A11["SLC7A11"]
    SLC7A11 -->|"activates"| DES
    BECN1["BECN1"]
    BECN1 -->|"activates"| DES
    GENES["GENES"]
    GENES -->|"therapeutic target"| DES
    AMPK["AMPK"]
    AMPK -->|"activates"| DES
    ABCB1["ABCB1"]
    ABCB1 -->|"associated with"| DES
    FAS["FAS"]
    FAS -->|"interacts with"| DES
    CASP8["CASP8"]
    CASP8 -->|"interacts with"| DES
    CASP6["CASP6"]
    CASP6 -->|"interacts with"| DES
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"activates"| DES
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| DES
    CANCER["CANCER"]
    CANCER -->|"associated with"| DES
    style DES fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0