concept

GD3S

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GD3S: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GD3S
Key Genes/Proteins	ST8SIA1
Related Diseases	Parkinsonism, Executive Dysfunction, MPTP-Induced Parkinsonism, Parkinson's Disease, Parkinson

Wiki Pages (17)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GD3S["GD3S"]
    GD3S -.protects against.-> Parkinsonism["Parkinsonism"]
    GD3S -.protects against.-> Executive_Dysfunction["Executive Dysfunction"]
    GD3S -.protects against.-> MPTP_Induced_Parkinsonism["MPTP-Induced Parkinsonism"]
    GD3S -.protects against.-> Parkinson_s_Disease["Parkinson's Disease"]
    GD3S -->|"target for"| Parkinson["Parkinson"]
    GD3S -->|"activates"| ALS["ALS"]
    GD3S -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ST8SIA1["ST8SIA1"] -->|"expressed in"| GD3S
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| GD3S
    NEUROTOXICITY["NEUROTOXICITY"] -->|"activates"| GD3S
    PARKINSON["PARKINSON"] -->|"activates"| GD3S
    RNA["RNA"] -->|"regulates"| GD3S

Outgoing (56)

Target	Relation	Type	Str
Parkinsonism	protects_against	disease	0.95
Executive Dysfunction	protects_against	phenotype	0.95
MPTP-Induced Parkinsonism	protects_against	disease	0.95
Parkinson's Disease	protects_against	disease	0.80
neurons	expressed_in	cell_type	0.70
striatum	expressed_in	brain_region	0.70
Parkinson	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	interacts_with	disease	0.65
Aging	inhibits	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	protects_against	disease	0.65
AND	protects_against	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
PSEN1	regulates	gene	0.60
AMYLOID	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
Amyloid	inhibits	pathway	0.60
Neuron	protects_against	cell_type	0.60
AGING	inhibits	gene	0.60
Neuron	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
ST8SIA1	activates	gene	0.60
PARKINSON	activates	gene	0.60
ST8SIA1	regulates	gene	0.60
RNA	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
APP	regulates	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
APP/PSEN1	regulates	gene	0.60
ST8SIA1	interacts_with	gene	0.60
ST8SIA1	protects_against	gene	0.60
Amyloid-Beta	inhibits	protein	0.60
Ras	regulates	protein	0.60
Rb	therapeutic_target	protein	0.60
Rb	inhibits	protein	0.60
neurodegeneration	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
PSEN1	interacts_with	gene	0.60

Incoming (21)

Source	Relation	Type	Str
ST8SIA1	expressed_in	gene	0.95
ST8SIA1	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
PARKINSON	activates	gene	0.60
ST8SIA1	activates	gene	0.60
PARKINSON	regulates	gene	0.60
RNA	regulates	gene	0.60
AGING	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
APP	regulates	gene	0.60
APP/PSEN1	regulates	gene	0.60
ST8SIA1	interacts_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
AMYLOID	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
APP	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GD3S

Understanding Entity Pages

Wiki Pages (17)

Gangliosides in Neurodegeneration

Physical Therapy and Rehabilitation for Atypical Parkinsonism

Sphingolipid Signaling Pathway in Neurodegeneration

Section 188: Advanced Lipidomics and Membrane Therapy in CBS/PSP

Ganglioside and Membrane Lipid Raft Dysfunction in 4R-Tauopathies

Physical Therapy and Rehabilitation for Atypical Parkinsonism

Ganglioside Sialylation in Tau Internalization

Section 134: Advanced Lipidomics and Membrane Therapy in CBS/PSP

Lipid Dysregulation in Neurodegeneration

Wearable Sensors and Digital Biomarkers for Atypical Parkinsonism (CBS/PSP)

Sphingolipid Metabolism Dysregulation in 4R-Tauopathies

stem-cell-therapy-parkinsonism

Sphingolipid Metabolism in Neurodegeneration

ad-sphingolipid-ceramide-companies

Section 136: Advanced Glycomics and Glycobiology Therapy in CBS/PSP