GOT2

Understanding Entity Pages

This page aggregates everything SciDEX knows about GOT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GOT2 encodes mitochondrial aspartate aminotransferase, a key enzyme in the malate-aspartate shuttle with roles in neurodegeneration

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graph TD
    GOT2["<b>GOT2</b>"]
    Cardiac{"Cardiac"}
    GOT2 -->|"regulates"| Cardiac
    Ms{"Ms"}
    GOT2 -->|"regulates"| Ms
    Cardiovascular{"Cardiovascular"}
    GOT2 -->|"regulates"| Cardiovascular
    Mitophagy(["Mitophagy"])
    GOT2 -->|"regulates"| Mitophagy
    neurodegeneration["neurodegeneration"]
    GOT2 -->|"implicated in"| neurodegeneration
    P4HB["P4HB"]
    P4HB -->|"regulates"| GOT2
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| GOT2
    PTGS2["PTGS2"]
    PTGS2 -->|"regulates"| GOT2
    GRB2["GRB2"]
    GRB2 -->|"regulates"| GOT2
    NDP52["NDP52"]
    NDP52 -->|"regulates"| GOT2
    GSK3B["GSK3B"]
    GSK3B -->|"regulates"| GOT2
    style GOT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0