Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about p4hb: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | P4HB |
| Chromosome | 17q25.3 |
| Function | P4HB - Prolyl 4-Hydroxylase Subunit Beta is involved in cellular protein quality control mechanisms essential for neuronal survival. |
| Molecular Weight | 57 kDa |
| UniProt ID | P07237 |
| NCBI Gene ID | 5035 |
| Ensembl ID | ENSG00000185684 |
| OMIM | 176790 |
| GeneCards | P4HB |
| Human Protein Atlas | P4HB |
| Associated Diseases | Als, Tumor, Cancer, Ms, Carcinoma, neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
P4HB["P4HB"]
P4HB -->|"regulates"| Cardiac["Cardiac"]
P4HB -->|"regulates"| Ms["Ms"]
P4HB -->|"regulates"| Cardiovascular["Cardiovascular"]
P4HB -->|"expressed in"| Tumor["Tumor"]
P4HB -->|"expressed in"| Senescence["Senescence"]
P4HB -->|"expressed in"| Cancer["Cancer"]
P4HB -->|"expressed in"| Ataxia["Ataxia"]
P4HB -->|"activates"| Diabetes["Diabetes"]
ROS["ROS"] -->|"activates"| P4HB
PRMT1["PRMT1"] -->|"activates"| P4HB
RNA["RNA"] -->|"activates"| P4HB
CYP11A1["CYP11A1"] -->|"activates"| P4HB| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiac | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Senescence | expressed_in | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Ataxia | expressed_in | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Diabetes | activates | disease | 0.65 |
| Fibrosis | regulates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| PTGS2 | regulates | gene | 0.60 |
| GRB2 | regulates | gene | 0.60 |
| NDP52 | regulates | gene | 0.60 |
| GSK3B | regulates | gene | 0.60 |
| GOT2 | regulates | gene | 0.60 |
| MT2A | associated_with | gene | 0.60 |
| TERT | expressed_in | gene | 0.60 |
| CFL1 | associated_with | gene | 0.60 |
| ATM | expressed_in | gene | 0.60 |
| SOD2 | associated_with | gene | 0.60 |
| CD8 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| TNFSF10 | associated_with | gene | 0.60 |
| Rb | regulates | protein | 0.60 |
| VIMENTIN | activates | gene | 0.60 |
| Fibronectin | activates | protein | 0.60 |
| BMP4 | therapeutic_target | gene | 0.60 |
| SHH | therapeutic_target | gene | 0.60 |
| MITOPHAGY | regulates | gene | 0.60 |
| Mitophagy | regulates | pathway | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Er Stress | associated_with | pathway | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| Ras | inhibits | protein | 0.60 |
| Epithelial | activates | cell_type | 0.60 |
| Collagen | activates | protein | 0.60 |
| Fus | interacts_with | protein | 0.60 |
| HEDGEHOG | therapeutic_target | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| Fibroblast | therapeutic_target | cell_type | 0.60 |
| Collagen | therapeutic_target | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||