gene

HERC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HERC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

Summary

HERC2 (HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 2): large E3 ubiquitin ligase involved in DNA damage repair, protein quality control, autophagy, and linked to Alzheimer's disease, Angelman syndrome, and neurodegeneration.

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🧬 Gene Info

Gene Symbol	HERC2
Full Name	HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 2
Chromosome	15q13.1
Protein Family	HERC family (HECT-type E3 ubiquitin ligases)
Function	is a hallmark of aging and neurodegenerative diseases.
Molecular Weight	500 kDa
Amino Acids	834 aa
Pathways	mTOR, mtor
UniProt ID	Q9Y5K5
NCBI Gene ID	8924
Ensembl ID	ENSG00000128731
OMIM	607318
GeneCards	HERC2
Human Protein Atlas	HERC2
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	CANCER, INFLAMMATION, JAK2, LC3, STAT3, ULK1
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HERC2 — AlphaFold Q9Y5K5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HERC2 Gene

gene · 2395 words

→

HERC2 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 2

protein · 647 words

→

Pathway Diagram

graph TD
    HERC2["HERC2"]
    Tumor{"Tumor"}
    HERC2 -->|"activates"| Tumor
    Hepatocellular_Carcinoma{"Hepatocellular Carcinoma"}
    HERC2 -->|"activates"| Hepatocellular_Carcinoma
    Cancer{"Cancer"}
    HERC2 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    HERC2 -->|"activates"| Carcinoma
    Inflammation{"Inflammation"}
    HERC2 -->|"activates"| Inflammation
    UBIQUITIN["UBIQUITIN"]
    HERC2 -->|"associated_with"| UBIQUITIN
    STAT3["STAT3"]
    STAT3 -->|"activates"| HERC2
    JAK2["JAK2"]
    JAK2 -->|"activates"| HERC2
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| HERC2
    CANCER["CANCER"]
    CANCER -->|"activates"| HERC2
    neurodegeneration["neurodegeneration"]
    HERC2 -->|"implicated_in"| neurodegeneration

Outgoing (10)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
autophagy pathway	participates_in	pathway	0.60
ULK1	activates	gene	0.60
LC3	activates	gene	0.60
autism spectrum disorder	interacts_with	disease	0.60
UBIQUITIN	associated_with	gene	0.60

Incoming (4)

Source	Relation	Type	Str
STAT3	activates	gene	0.60
JAK2	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HERC2 in their description or question text

No additional research found