concept

HMGB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HMGB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

23Outgoing

8Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	HMGB2
Key Genes/Proteins	PCSK9, SOD1, SIRT1, PPAR-Γ, AND
Related Diseases	Als, Ms, ALS, Anorectal Malformation
Related Pathways	Complement, Innate Immunity, Sod1

Pathway Diagram

graph TD
    HMGB2["HMGB2"]
    HMGB2 -->|"expressed in"| Als["Als"]
    HMGB2 -->|"activates"| Ms["Ms"]
    HMGB2 -->|"expressed in"| ALS["ALS"]
    HMGB2 -.biomarker for.-> Anorectal_Malformation["Anorectal Malformation"]
    HMGB2 -->|"expressed in"| Complement["Complement"]
    HMGB2 -->|"inhibits"| PCSK9["PCSK9"]
    SOD1["SOD1"] -->|"inhibits"| HMGB2
    PCSK9 -->|"inhibits"| HMGB2
    GLUT4["GLUT4"] -->|"activates"| HMGB2
    SIRT1["SIRT1"] -->|"inhibits"| HMGB2
    AND["AND"] -->|"inhibits"| HMGB2
    RNA["RNA"] -->|"expressed in"| HMGB2

Outgoing (23)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Ms	activates	disease	0.65
ALS	expressed_in	disease	0.65
Anorectal Malformation	biomarker_for	disease	0.65
Complement	expressed_in	pathway	0.60
PCSK9	inhibits	gene	0.60
SOD1	inhibits	gene	0.60
Complement	interacts_with	pathway	0.60
Innate Immunity	contributes_to	pathway	0.60
SIRT1	inhibits	gene	0.60
PPAR-Γ	inhibits	gene	0.60
Sod1	inhibits	pathway	0.60
AND	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
MMP12	activates	gene	0.60
PDGFA	activates	gene	0.60
PLAU	activates	gene	0.60
S100A8	activates	gene	0.60
S100A9	activates	gene	0.60
TGM2	activates	gene	0.60
ARM	associated_with	disease	0.56

Incoming (8)

Source	Relation	Type	Str
SOD1	inhibits	gene	0.60
PCSK9	inhibits	gene	0.60
GLUT4	activates	gene	0.60
SIRT1	inhibits	gene	0.60
AND	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
ACE2	activates	gene	0.60
CLU	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found