PDGFA

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PDGFA encodes PDGF-A, a growth factor involved in glial cell development, myelination, and neuroprotection. Associated with Parkinson's disease, ALS, and white matter disorders.

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graph TD
    PDGFA["<b>PDGFA</b>"]
    Ms{"Ms"}
    PDGFA -->|"interacts with"| Ms
    Glioblastoma{"Glioblastoma"}
    PDGFA -->|"therapeutic target"| Glioblastoma
    Akt(["Akt"])
    PDGFA -->|"activates"| Akt
    neurodegeneration["neurodegeneration"]
    PDGFA -->|"implicated in"| neurodegeneration
    PDGFRA["PDGFRA"]
    PDGFRA -->|"inhibits"| PDGFA
    AKT["AKT"]
    AKT -->|"activates"| PDGFA
    EPHA2["EPHA2"]
    EPHA2 -->|"inhibits"| PDGFA
    GBM["GBM"]
    GBM -->|"inhibits"| PDGFA
    style PDGFA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0