Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLUT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GLUT4 is a concept in neurodegeneration research. Key relationships include: activates, protects against, inhibits. Associated with AD, Aging, Als. Connected to 146 entities in the SciDEX knowledge graph.
| Name | GLUT4 |
| Key Genes/Proteins | CYP2E1, NRF2, TUG, AMPK, AKT |
| Related Diseases | Obesity, Alzheimer, Als, Neurodegeneration |
| Related Pathways | Cholesterol |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
GLUT4["GLUT4"]
GLUT4 -->|"activates"| Diabetes["Diabetes"]
GLUT4 -->|"activates"| Obesity["Obesity"]
GLUT4 -->|"activates"| Neuroinflammation["Neuroinflammation"]
GLUT4 -->|"activates"| Inflammation["Inflammation"]
GLUT4 -->|"activates"| Aging["Aging"]
GLUT4 -->|"activates"| Ms["Ms"]
GLUT4 -->|"target for"| Stroke["Stroke"]
GLUT4 -->|"activates"| Fibrosis["Fibrosis"]
GLUT4 -->|"target for"| Neurodegeneration["Neurodegeneration"]
GLUT4 -->|"activates"| Alzheimer["Alzheimer"]
CYP2E1["CYP2E1"] -->|"inhibits"| GLUT4
NRF2["NRF2"] -->|"inhibits"| GLUT4
FGFR1["FGFR1"] -->|"activates"| GLUT4
FGF21["FGF21"] -->|"activates"| GLUT4
SOD2["SOD2"] -->|"activates"| GLUT4
BACE1["BACE1"] -->|"activates"| GLUT4
PI3K["PI3K"] -->|"activates"| GLUT4
MTOR["MTOR"] -->|"inhibits"| GLUT4
PLIN1["PLIN1"] -->|"activates"| GLUT4
AND["AND"] -->|"activates"| GLUT4| Target | Relation | Type | Str |
|---|---|---|---|
| Brain Glucose Metabolism | involved_in | process | 0.90 |
| Obesity | activates | disease | 0.75 |
| Alzheimer | activates | disease | 0.75 |
| Als | activates | disease | 0.75 |
| Als | protects_against | disease | 0.75 |
| Neurodegeneration | protects_against | disease | 0.75 |
| AMPK | activates | gene | 0.70 |
| AKT | activates | gene | 0.70 |
| Cholesterol | activates | pathway | 0.70 |
| SIRT1 | activates | gene | 0.70 |
| Diabetes | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Stroke | therapeutic_target | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Cardiovascular | activates | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Metabolic Syndrome | therapeutic_target | disease | 0.65 |
| Obesity | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Rheumatoid Arthritis | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Neuroblastoma | biomarker_for | disease | 0.65 |
| Neuropathy | protects_against | disease | 0.65 |
| Diabetes | protects_against | disease | 0.65 |
| Type 2 Diabetes | protects_against | disease | 0.65 |
| Insulin Resistance | biomarker_for | disease | 0.65 |
| Dementia | protects_against | disease | 0.65 |
| Neuroinflammation | protects_against | disease | 0.65 |
| Inflammation | protects_against | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Diabetes | therapeutic_target | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Alzheimer | protects_against | disease | 0.65 |
| ALS | protects_against | disease | 0.65 |
| TSC2 | activates | gene | 0.65 |
| INSULIN SIGNALING | regulates | pathway | 0.65 |
| EPILEPSY | transports | disease | 0.65 |
| GFAP | activates | gene | 0.65 |
| GFAP | regulates | gene | 0.65 |
| NOX4 | activates | gene | 0.60 |
| SOD1 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TUG | interacts_with | entity | 0.95 |
| CYP2E1 | inhibits | protein | 0.90 |
| NRF2 | inhibits | protein | 0.90 |
| TUG | binds | protein | 0.90 |
| h-075f1f02 | targets_gene | hypothesis | 0.90 |
| AMPK | activates | protein | 0.85 |
| NEURODEGENERATION | protects_against | gene | 0.70 |
| NEURODEGENERATION | inhibits | phenotype | 0.70 |
| AKT | phosphorylates | gene | 0.70 |
| AKT | causes | gene | 0.70 |
| NEURONS | activates | cell_type | 0.70 |
| ASTROCYTES | activates | cell_type | 0.65 |
| ASTROCYTES | inhibits | cell_type | 0.65 |
| FGFR1 | activates | gene | 0.60 |
| FGF21 | activates | gene | 0.60 |
| SOD2 | activates | gene | 0.60 |
| BACE1 | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| MTOR | inhibits | gene | 0.60 |
| PLIN1 | activates | gene | 0.60 |
| PPAR | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| PTEN | inhibits | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| TNF | inhibits | gene | 0.60 |
| BAX | biomarker_for | gene | 0.60 |
| CREB | biomarker_for | gene | 0.60 |
| APOPTOSIS | biomarker_for | gene | 0.60 |
| INSULIN RESISTANCE | biomarker_for | gene | 0.60 |
| NRXN3 | protects_against | gene | 0.60 |
| PDHA1 | protects_against | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| PRKAA1 | protects_against | gene | 0.60 |
| INFLAMMATION | protects_against | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | protects_against | gene | 0.60 |
| SOD2 | protects_against | gene | 0.60 |
| NEUROINFLAMMATION | protects_against | gene | 0.60 |
| GENES | protects_against | gene | 0.60 |
| SOD1 | protects_against | gene | 0.60 |
| CREB | activates | gene | 0.60 |
| NLGN2 | protects_against | gene | 0.60 |
| APP/PS1 | activates | gene | 0.60 |
| DIABETES MELLITUS | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| SOD1 | activates | gene | 0.60 |
| CAT | protects_against | gene | 0.60 |
| PKM | protects_against | gene | 0.60 |
| SLC2A2 | protects_against | gene | 0.60 |
| PER | protects_against | gene | 0.60 |
| GSK3B | protects_against | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||