gene

PLAU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

PLAU encodes urokinase-type plasminogen activator, a serine protease involved in fibrinolysis, extracellular matrix remodeling, and neuroinflammation. It plays complex roles in neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	PLAU
Aliases	uPA, urokinase, ATF
Chromosome	10q22.2
Protein Type	Protease
Function	is a gene encoding a secreted serine protease that plays critical roles in fibrinolysis, extracellular matrix (ECM) remodeling, and cell migration.
Molecular Weight	~54 kDa (pro-enzyme)
Amino Acids	411 aa
Exons	11
Pathways	TGF-β
UniProt ID	P00750
NCBI Gene ID	5328
GeneCards	PLAU
Human Protein Atlas	PLAU
Gene Name	Urokinase-type plasminogen activator
Entrez Gene ID	5328
Associated Diseases	Als, Alzheimer, Leukemia, Ms
Interactions	CXCL10, CX3CL1, VIM, BDNF, FGF23, FGF21
KG Connections	175 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLAU — AlphaFold P00750 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PLAU["PLAU"] -->|"biomarker for"| Inflammation["Inflammation"]
    PLAU["PLAU"] -->|"biomarker for"| Senescence["Senescence"]
    PLAU["PLAU"] -->|"biomarker for"| Als["Als"]
    PLAU["PLAU"] -->|"biomarker for"| Aging["Aging"]
    PLAU["PLAU"] -->|"biomarker for"| Longevity["Longevity"]
    PLAU["PLAU"] -->|"biomarker for"| Fibrosis["Fibrosis"]
    FGF21["FGF21"] -->|"activates"| PLAU["PLAU"]
    APP["APP"] -->|"biomarker for"| PLAU["PLAU"]
    FNDC5["FNDC5"] -->|"activates"| PLAU["PLAU"]
    S100B["S100B"] -->|"biomarker for"| PLAU["PLAU"]
    style PLAU fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (104)

Target	Relation	Type	Str
Inflammation	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Longevity	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Als	regulates	disease	0.65
ALS	biomarker_for	disease	0.65
Alzheimer	associated_with	disease	0.65
CXCL10	activates	gene	0.60
C1Q	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
VIM	activates	gene	0.60
BDNF	activates	gene	0.60
TGM2	biomarker_for	gene	0.60
GPNMB	biomarker_for	gene	0.60
HMGB1	biomarker_for	gene	0.60
FGF23	activates	gene	0.60
APP	biomarker_for	gene	0.60
FGF21	activates	gene	0.60
S100B	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
AKT	associated_with	gene	0.60
TNF	associated_with	gene	0.60
NME1	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
SPP1	associated_with	gene	0.60
FTL	associated_with	gene	0.60
AKT	regulates	gene	0.60
VIMENTIN	activates	gene	0.60
PROGRANULIN	activates	entity	0.60
BDNF	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
IL6	associated_with	gene	0.60
ACE	associated_with	gene	0.60
HSPG2	associated_with	gene	0.60
PRNP	associated_with	gene	0.60
IDE	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
Ghrelin	biomarker_for	protein	0.60
Leptin	activates	protein	0.60
Adiponectin	biomarker_for	protein	0.60
Fibronectin	activates	protein	0.60
IL1A	associated_with	gene	0.60
SORL1	associated_with	gene	0.60

Incoming (71)

Source	Relation	Type	Str
FGF21	activates	gene	0.60
APP	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
S100B	biomarker_for	gene	0.60
CXCL10	activates	gene	0.60
LGALS3	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
FGF19	associated_with	gene	0.60
PI3K	regulates	gene	0.60
GBA1	regulates	gene	0.60
GPNMB	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
PROGRANULIN	activates	gene	0.60
BDNF	activates	gene	0.60
FGF23	activates	gene	0.60
VIM	activates	gene	0.60
C1Q	biomarker_for	gene	0.60
VIMENTIN	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
TGM2	biomarker_for	gene	0.60
SORL1	associated_with	gene	0.60
IL1A	associated_with	gene	0.60
IL10	associated_with	gene	0.60
IL6	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
PRNP	associated_with	gene	0.60
IDE	associated_with	gene	0.60
HSPG2	associated_with	gene	0.60
ACE	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
KL	activates	gene	0.60
ACE	interacts_with	gene	0.60
BACE1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IDE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
GDF15	activates	gene	0.60
CLU	activates	gene	0.60
MMP12	activates	gene	0.60
PDGFA	activates	gene	0.60
ERK	associated_with	gene	0.60
JAK	associated_with	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
AGING	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PLAU

Understanding Entity Pages

Summary

Wiki Pages (7)

PLAU Gene (Urokinase)

First-in-Human 4R Tau Ligand Study in PSP (NCT07348276)

PLG — Plasminogen

PLAU Protein

PDGFA — Platelet-Derived Growth Factor Subunit A

Proteins