gene

MMP12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

116Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

Summary

MMP12 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, Als, Alzheimer. Connected to 62 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MMP12
Full Name	Matrix Metalloproteinase 12
Aliases	Page for MMP12
Chromosome	11q22.2
Protein Type	Enzyme
Function	MMP12 encodes a matrix metalloproteinase with unique substrate specificity and physiological functions.
Primary Expression	macrophages and microglia
Amino Acids	470 aa
Pathways	Immune Response, Lipid Metabolism
Ensembl ID	ENSG00000196612
GeneCards	MMP12
Human Protein Atlas	MMP12
Elastin Degradation	MMP12 is one of the few human enzymes capable of degrading native (cross-linked) elastin, making it essential for tissue remodeling in lungs, blood vessels, and other elastic tissues. [@shapiro2019]
Extracellular Matrix Remodeling	Beyond elastin, MMP12 can degrade various matrix components including collagen IV, laminin, and fibronectin.
Prodomain Function	The propeptide domain maintains latency; activation requires cleavage by other proteases including plasmin, matrilysin (MMP7), and stromelysin (MMP3).
Associated Diseases	Als, Coronary Artery Disease, Inflammation, Stroke
Interactions	CXCL1, AXL, CXCL10, CHIT1, TYROBP, SPI1
KG Connections	116 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MMP12["<b>MMP12</b>"]
    Atherosclerosis{"Atherosclerosis"}
    MMP12 -->|"therapeutic target"| Atherosclerosis
    Als{"Als"}
    MMP12 -->|"therapeutic target"| Als
    Cardiovascular{"Cardiovascular"}
    MMP12 -->|"therapeutic target"| Cardiovascular
    Inflammation{"Inflammation"}
    MMP12 -->|"inhibits"| Inflammation
    ALS{"ALS"}
    MMP12 -->|"inhibits"| ALS
    MMP12 -->|"inhibits"| Cardiovascular
    MMP12 -->|"inhibits"| Atherosclerosis
    Innate_Immunity(["Innate Immunity"])
    MMP12 -->|"inhibits"| Innate_Immunity
    CHIT1["CHIT1"]
    MMP12 -->|"therapeutic target"| CHIT1
    CXCL1["CXCL1"]
    MMP12 -->|"inhibits"| CXCL1
    AXL["AXL"]
    MMP12 -->|"therapeutic target"| AXL
    MMP12 -->|"inhibits"| AXL
    CXCL1 -->|"inhibits"| MMP12
    CXCL10["CXCL10"]
    CXCL10 -->|"inhibits"| MMP12
    CHIT1 -->|"therapeutic target"| MMP12
    AXL -->|"therapeutic target"| MMP12
    AXL -->|"inhibits"| MMP12
    CXCL9["CXCL9"]
    CXCL9 -->|"inhibits"| MMP12
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"inhibits"| MMP12
    CHIT1 -->|"inhibits"| MMP12
    IL_6["IL-6"]
    IL_6 -->|"inhibits"| MMP12
    AND["AND"]
    AND -->|"inhibits"| MMP12
    style MMP12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (79)

Target	Relation	Type	Str
Atherosclerosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Coronary Artery Disease	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
CHIT1	therapeutic_target	gene	0.60
CXCL1	inhibits	gene	0.60
AXL	therapeutic_target	gene	0.60
AXL	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60
CHIT1	inhibits	gene	0.60
CD33	regulates	gene	0.60
TYROBP	activates	gene	0.60
APOE	regulates	gene	0.60
SPI1	activates	gene	0.60
HDAC9	associated_with	gene	0.60
ALDH2	associated_with	gene	0.60
APOE	associated_with	gene	0.60
IL6R	associated_with	gene	0.60
Il-17	inhibits	protein	0.60
HDAC8	inhibits	gene	0.60
Rb	inhibits	protein	0.60
PVALB	interacts_with	gene	0.60
PDGFA	activates	gene	0.60
PLAU	activates	gene	0.60
S100A8	activates	gene	0.60
S100A9	activates	gene	0.60
TGM2	activates	gene	0.60
Innate Immunity	inhibits	pathway	0.60
INFLAMMATION	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
GENES	activates	gene	0.60
MYELIN	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ASTROCYTES	activates	gene	0.60

Incoming (37)

Source	Relation	Type	Str
CXCL1	inhibits	gene	0.60
CXCL10	inhibits	gene	0.60
CHIT1	therapeutic_target	gene	0.60
AXL	therapeutic_target	gene	0.60
AXL	inhibits	gene	0.60
CHIT1	inhibits	gene	0.60
TREM2	regulates	gene	0.60
TAU	activates	gene	0.60
GAIN	activates	gene	0.60
STAT3	activates	gene	0.60
CXCL1	biomarker_for	entity	0.60
CXCL10	biomarker_for	entity	0.60
PVALB	associated_with	gene	0.60
IL22	associated_with	gene	0.60
IL6R	associated_with	gene	0.60
IL22	interacts_with	gene	0.60
IL6R	interacts_with	gene	0.60
CLU	activates	gene	0.60
CXCL9	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
AND	inhibits	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
STROKE	inhibits	gene	0.60
HDAC	inhibits	gene	0.60
CXCL9	biomarker_for	gene	0.60
ACE2	activates	gene	0.60
HMGB2	activates	gene	0.60
IL6R	activates	gene	0.50
IL22	activates	gene	0.50
PVALB	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found