Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HEARING LOSS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HEARING LOSS |
Knowledge base pages for this entity
graph TD
HEARING_LOSS["HEARING LOSS"]
HEARING_LOSS -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
HEARING_LOSS -->|"risk_factor_for"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
HEARING_LOSS -->|"risk_factor_for"| Alzheimer_S_Disease["Alzheimer'S Disease"]
HEARING_LOSS -->|"promotes"| Neuroinflammation["Neuroinflammation"]
HEARING_LOSS -->|"causes"| Amyloid_Beta["Amyloid-Beta"]
HEARING_LOSS -->|"causes"| AMYLOID["AMYLOID"]
Hair_Cell_Death["Hair Cell Death"] -->|"causes"| HEARING_LOSS
Phase_Separation_Dysregulation["Phase Separation Dysregulation"] -->|"contributes to"| HEARING_LOSS
Kanamycin["Kanamycin"] -->|"causes"| HEARING_LOSS
Furosemide["Furosemide"] -->|"causes"| HEARING_LOSS
BDNF["BDNF"] -.prevents.-> HEARING_LOSS| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | risk_factor_for | disease | 0.95 |
| ALZHEIMER'S DISEASE | risk_factor_for | disease | 0.95 |
| Alzheimer'S Disease | risk_factor_for | disease | 0.95 |
| Neuroinflammation | promotes | process | 0.93 |
| Amyloid-Beta | causes | protein | 0.92 |
| IBA1 | upregulates | protein | 0.90 |
| GFAP | upregulates | protein | 0.90 |
| IL1B | upregulates | protein | 0.90 |
| IL6 | upregulates | protein | 0.90 |
| TNF | upregulates | protein | 0.90 |
| Amyloid-Beta | upregulates | protein | 0.90 |
| Neuroinflammation | causes | process | 0.90 |
| AMYLOID | causes | protein | 0.90 |
| NEUROINFLAMMATION | promotes | process | 0.90 |
| RPS6KB1 | phosphorylates | protein | 0.88 |
| RPS6 | phosphorylates | protein | 0.88 |
| mTOR Pathway | activates | pathway | 0.85 |
| AMYLOID | upregulates | protein | 0.85 |
| MTOR | activates | gene | 0.80 |
| BETA-AMYLOID | increases | protein | 0.80 |
| Alzheimer's disease | causes | disease | 0.80 |
| MTOR | regulates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Hair Cell Death | causes | phenotype | 0.90 |
| Phase Separation Dysregulation | contributes_to | mechanism | 0.85 |
| Kanamycin | causes | drug | 0.85 |
| Furosemide | causes | drug | 0.85 |
| Phase Separation Dysregulation | associated_with | mechanism | 0.80 |
| BDNF | prevents | protein | 0.80 |
| EMX2 | associated_with | gene | 0.75 |
| BDNF | biomarker_for | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||