gene

RPS6KB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS6KB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

551Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

RPS6KB1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ADH, ALS. Connected to 304 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRPS6KB1
Chromosome17p13.3
Protein TypeSerine/Threonine Kinase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight70 kDa
Exons17
PathwaysmTOR, mtor
GeneCardsRPS6KB1
Human Protein AtlasRPS6KB1
IsoformFeatures
S6K1-p70Full-length, cytosolic
S6K1-p85Extended N-terminus
SiteKinase
Thr389mTORC1
Thr421/Ser424mTORC1
Associated DiseasesAD, ADH, AMI, Ischemia, Metabolic Syndrome, Ms
Known Drugs/Compoundsrapamycin
InteractionsGRB2, RHEB, STING1, EIF2A, LRRK2, ATG16L1
KG Connections551 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

RPS6KB1 Gene

gene · 1085 words

PPP2CA — Protein Phosphatase 2 Catalytic Subunit Alpha

gene · 1359 words

RPTOR — Regulatory Associated Protein of MTOR Complex 1

gene · 1315 words

LAMTOR2 Gene

gene · 1242 words

RXRA

gene · 1001 words

PSMA1 Gene

gene · 983 words

Pathway Diagram

graph TD
    RPS6KB1["RPS6KB1"] -->|"Activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| Ischemia["Ischemia"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| Ms["Ms"]
    RPS6KB1["RPS6KB1"] -->|"Interacts With"| Cancer["Cancer"]
    RPS6KB1["RPS6KB1"] -->|"Interacts With"| Als["Als"]
    RPS6KB1["RPS6KB1"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| RAB7A["RAB7A"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| SREBF1["SREBF1"]
    ACTB["ACTB"] -->|"Regulates"| RPS6KB1["RPS6KB1"]
    PPARA["PPARA"] -->|"Regulates"| RPS6KB1["RPS6KB1"]
    CAT["CAT"] -->|"Regulates"| RPS6KB1["RPS6KB1"]
    SQSTM1["SQSTM1"] -->|"Regulates"| RPS6KB1["RPS6KB1"]
    OPTN["OPTN"] -->|"Interacts With"| RPS6KB1["RPS6KB1"]
    style RPS6KB1 fill:#8d4900,color:#e0e0e0
    style Metabolic_Syndrome fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style RAB7A fill:#8d4900,color:#e0e0e0
    style SREBF1 fill:#8d4900,color:#e0e0e0
    style ACTB fill:#8d4900,color:#e0e0e0
    style PPARA fill:#8d4900,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style SQSTM1 fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0

Outgoing (296)

TargetRelationTypeStr
TAUphosphorylatesprotein0.95
RPS6phosphorylatesprotein0.90
Microtubule Disruptioncausesmechanism0.85
TAUregulatesprotein0.80
Mtoractivatespathway0.80

Incoming (255)

SourceRelationTypeStr
PRKAAinhibitsgene0.90
Hearing Lossphosphorylatesphenotype0.88
HEARING_LOSSactivatesphenotype0.80
APOPTOSISactivatesgene0.70
AUTOPHAGYactivatesgene0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found