gene

RPS6KB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS6KB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

547Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RPS6KB1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ADH, ALS. Connected to 304 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RPS6KB1
Chromosome	17p13.3
Protein Type	Serine/Threonine Kinase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	70 kDa
Exons	17
Pathways	mTOR, mtor
GeneCards	RPS6KB1
Human Protein Atlas	RPS6KB1
Associated Diseases	AD, ADH, AMI, disease, Ischemia, metabolic syndrome
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, AKT1S1, AMBRA1, AMPK
KG Connections	547 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RPS6KB1 Gene

gene · 1085 words

→

p70S6K (RPS6KB1) Protein

protein · 782 words

→

Pathway Diagram

graph TD
    RPS6KB1["RPS6KB1"] -->|"Activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| Ischemia["Ischemia"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| Ms["Ms"]
    RPS6KB1["RPS6KB1"] -->|"Interacts With"| Cancer["Cancer"]
    RPS6KB1["RPS6KB1"] -->|"Interacts With"| Als["Als"]
    RPS6KB1["RPS6KB1"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| RAB7A["RAB7A"]
    RPS6KB1["RPS6KB1"] -->|"Regulates"| SREBF1["SREBF1"]
    ACTB["ACTB"] -->|"Regulates"| RPS6KB1["RPS6KB1"]
    PPARA["PPARA"] -->|"Regulates"| RPS6KB1["RPS6KB1"]
    CAT["CAT"] -->|"Regulates"| RPS6KB1["RPS6KB1"]
    SQSTM1["SQSTM1"] -->|"Regulates"| RPS6KB1["RPS6KB1"]
    OPTN["OPTN"] -->|"Interacts With"| RPS6KB1["RPS6KB1"]
    style RPS6KB1 fill:#8d4900,color:#e0e0e0
    style Metabolic_Syndrome fill:#b71c1c,color:#e0e0e0
    style Ischemia fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style RAB7A fill:#8d4900,color:#e0e0e0
    style SREBF1 fill:#8d4900,color:#e0e0e0
    style ACTB fill:#8d4900,color:#e0e0e0
    style PPARA fill:#8d4900,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style SQSTM1 fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0

Outgoing (295)

Target	Relation	Type	Str
TAU	phosphorylates	protein	0.95
RPS6	phosphorylates	protein	0.90
Microtubule Disruption	causes	mechanism	0.85
TAU	regulates	protein	0.80
Mtor	activates	pathway	0.80
Autophagy	activates	pathway	0.80
Cancer	activates	disease	0.75
autophagy pathway	participates_in	pathway	0.70
Apoptosis	activates	pathway	0.70
Apoptosis	inhibits	process	0.70
MTOR	activates	gene	0.70
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Senescence	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Tauopathy	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Ischemia	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Als	regulates	disease	0.65
Metabolic Syndrome	associated_with	disease	0.65
Ms	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Alzheimer's disease	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
SMAD	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
S6K1	activates	gene	0.60
TRPML1	activates	gene	0.60
neurodegeneration	associated_with	disease	0.60
TP53	activates	gene	0.60
SFN	activates	gene	0.60

Incoming (252)

Source	Relation	Type	Str
PRKAA	inhibits	gene	0.90
Hearing Loss	phosphorylates	phenotype	0.88
HEARING_LOSS	activates	phenotype	0.80
APOPTOSIS	activates	gene	0.70
rapamycin	targets	drug	0.70
AUTOPHAGY	activates	gene	0.70
MTORC1	activates	gene	0.70
AKT1	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
CAT	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
PIK3C3	regulates	gene	0.60
RPS6	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
MTOR	regulates	gene	0.60
CFTR	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
EIF4EBP1	regulates	gene	0.60
MYC	regulates	gene	0.60
GABARAP	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
EGFR	regulates	gene	0.60
LAMP1	regulates	gene	0.60
MAPK14	interacts_with	gene	0.60
RAB7A	regulates	gene	0.60
LRP2	regulates	gene	0.60
MLKL	interacts_with	gene	0.60
MTOR	activates	gene	0.60
IL6	regulates	gene	0.60
FAS	regulates	gene	0.60
MAPK1	regulates	gene	0.60
IL1B	regulates	gene	0.60
AKT	regulates	gene	0.60
MECP2	regulates	gene	0.60
CASP3	regulates	gene	0.60
BDNF	regulates	gene	0.60
SP1	biomarker_for	gene	0.60
RELB	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPS6KB1 in their description or question text

No additional research found