Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ITPR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) is a ligand-gated calcium release channel in the endoplasmic reticulum that mediates calcium signaling in neurons. Dysfunction contributes to Alzheimer's disease, Parkinson's disease, and Huntington's disease.
| Gene Symbol | ITPR2 |
| Function | IP3R2 is one of three mammalian IP3 receptor isoforms |
| Primary Expression | neurons and endocrine cells - Channel Properties: Forms tetrameric channels (~1 |
| Molecular Weight | 270 kDa |
| Ensembl ID | ENSG00000123104 |
| GeneCards | ITPR2 |
| Human Protein Atlas | ITPR2 |
| Calcium Release Channel | Opens in response to IP3 binding, releasing Ca²⁺ from ER stores |
| Calcium Signaling | Generates cytosolic Ca²⁺ waves for various cellular processes |
| Tissue Distribution | Predominantly expressed in neurons and endocrine cells |
| Channel Properties | Forms tetrameric channels (~1.4 MDa) |
| Neuronal Calcium Signaling | Regulates Ca²⁺ dynamics in neurons |
| Synaptic Plasticity | Ca²⁺ release affects LTP, LTD, and neurotransmitter release |
| Gene Expression | Ca²⁺ influx activates transcription factors (CREB, NFAT) |
| Metabolism | Links G-protein signaling to metabolic responses |
| Associated Diseases | Infection, Parkinson, Viral Infection |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ITPR2("ITPR2")
Ms{"Ms"}
ITPR2 -->|"protects_against"| Ms
Als{"Als"}
ITPR2 -->|"protects_against"| Als
Infection{"Infection"}
ITPR2 -->|"associated_with"| Infection
Parkinson{"Parkinson"}
ITPR2 -->|"associated_with"| Parkinson
Viral_Infection{"Viral Infection"}
ITPR2 -->|"associated_with"| Viral_Infection
LRRK2["LRRK2"]
ITPR2 -->|"associated_with"| LRRK2
PARKINSON["PARKINSON"]
ITPR2 -->|"associated_with"| PARKINSON
NFKB1["NFKB1"]
ITPR2 -->|"associated_with"| NFKB1
VIRAL_INFECTIONS["VIRAL INFECTIONS"]
ITPR2 -->|"associated_with"| VIRAL_INFECTIONS
UBIQUITIN["UBIQUITIN"]
ITPR2 -->|"associated_with"| UBIQUITIN
Mitophagy(["Mitophagy"])
ITPR2 -->|"associated_with"| Mitophagy
P2RY1["P2RY1"]
P2RY1 -->|"protects_against"| ITPR2
YWHAB["YWHAB"]
YWHAB -->|"associated_with"| ITPR2
MITOPHAGY["MITOPHAGY"]
MITOPHAGY -->|"associated_with"| ITPR2
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated_with"| ITPR2| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | protects_against | disease | 0.65 |
| Als | protects_against | disease | 0.65 |
| Infection | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Viral Infection | associated_with | disease | 0.65 |
| ALS | protects_against | disease | 0.65 |
| LRRK2 | associated_with | gene | 0.60 |
| NFKB1 | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| P2RY1 | protects_against | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| YWHAB | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| VIRAL INFECTIONS | associated_with | gene | 0.60 |
| Mitophagy | associated_with | pathway | 0.60 |
| ATP | protects_against | gene | 0.60 |
| ASTROCYTES | associated_with | gene | 0.60 |
| SYNAPSE | protects_against | gene | 0.60 |
| Neuron | protects_against | cell_type | 0.60 |
| Astrocyte | associated_with | cell_type | 0.60 |
| AND | protects_against | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Astrocytes | inhibits | cell_type | 0.50 |
| SYNAPSE | inhibits | concept | 0.50 |
| NUCLEUS | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| P2RY1 | protects_against | gene | 0.60 |
| YWHAB | associated_with | gene | 0.60 |
| MITOPHAGY | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| SYNAPSE | protects_against | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||