Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about JAK/STAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | JAK/STAT |
| Summary | Page for JAK/STAT Inhibitors for Neurodegeneration |
| Key Genes/Proteins | INFLAMMATORY MEDIATORS, SOCS, SOCS1 |
| Related Diseases | Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia, Spinal Cord Injury, Dementia, apoptosis, Chemoresistance |
| Related Pathways | Cell Proliferation, inflammation-associated genes |
Knowledge base pages for this entity
graph TD
JAK_STAT["JAK/STAT"]
JAK_STAT -->|"involved_in"| Philadelphia_Chromosome_Like_A["Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia"]
JAK_STAT -->|"mediates"| Anti_Apoptosis["Anti-Apoptosis"]
JAK_STAT -->|"mediates"| Cell_Proliferation["Cell Proliferation"]
JAK_STAT -->|"mediates"| Cell_Differentiation["Cell Differentiation"]
JAK_STAT -->|"involved_in"| Normal_Hematopoiesis["Normal Hematopoiesis"]
JAK_STAT -->|"involved_in"| Immune_Response["Immune Response"]
JAK_STAT -->|"activates"| apoptosis["apoptosis"]
LRWE["LRWE"] -->|"inhibits"| JAK_STAT
IL_6["IL-6"] -->|"activates"| JAK_STAT
SOCS["SOCS"] -->|"inhibits"| JAK_STAT
PI3K["PI3K"] -->|"inhibits"| JAK_STAT
PIAS["PIAS"] -->|"inhibits"| JAK_STAT| Target | Relation | Type | Str |
|---|---|---|---|
| Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia | involved_in | disease | 0.95 |
| Spinal Cord Injury | implicated_in | disease | 0.95 |
| Neuroinflammation | activates | process | 0.90 |
| Pro-Inflammatory Cytokine Expression | promotes | process | 0.85 |
| Dementia | involved_in | disease | 0.82 |
| apoptosis | activates | phenotype | 0.80 |
| Cell Proliferation | activates | biological_process | 0.80 |
| Chemoresistance | contributes_to | phenotype | 0.80 |
| Parkinson's disease | implicated_in | disease | 0.80 |
| inflammation-associated genes | upregulates | biological_process | 0.80 |
| INFLAMMATORY MEDIATORS | regulates_production_of | protein | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LRWE | inhibits | drug | 0.90 |
| IL-6 | activates | entity | 0.90 |
| SOCS | inhibits | protein | 0.80 |
| SOCS1 | inhibits | gene | 0.80 |
| PIAS3 | inhibits | gene | 0.80 |
| IFN-Γ | activates | protein | 0.80 |
| PI3K | inhibits | pathway | 0.70 |
| PI3K | activates | pathway | 0.70 |
| PIAS | inhibits | protein | 0.70 |
| AKT | activates | gene | 0.70 |
| GFAP | activates | gene | 0.55 |
| VCP | activates | gene | 0.55 |
| VCP | involved_in | gene | 0.55 |
| APOE | aggregation | gene | 0.55 |
| GFAP | inhibits | gene | 0.55 |
| TET2 | transports | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||