gene

SOCS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOCS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections
0Hypotheses
0Analyses
50Outgoing
30Incoming

Summary

SOCS1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 36 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSOCS1
AliasesJAB, SSI-1, TIPID, SOCS-1
Chromosome16p13.13
Protein TypeSOCS family negative regulator
Functionis a critical negative regulator of the JAK-STAT signaling pathway.
Primary ExpressionImmune cells, neurons, astrocytes, microglia, widespread
PathwaysJAK-STAT signaling
UniProt IDO35744
NCBI Gene ID8651
Ensembl IDENSG00000185338
OMIM603597
GeneCardsSOCS1
Human Protein AtlasSOCS1
Gene NameSuppressor of Cytokine Signaling 1
Protein ClassSOCS family negative regulator
Associated DiseasesLymphoma, Ms
InteractionsJAK1, STAT6, STAT1, IL1B, FOSB, APP
KG Connections86 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SOCS1 — AlphaFold O35744 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SOCS1 Gene

gene · 1702 words

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

mechanism · 7227 words

Epigenetic Dysregulation in Neurodegeneration

mechanism · 4376 words

Epigenetic Alterations in Alzheimer's Disease

mechanism · 4331 words

RNA Metabolism Dysregulation in Alzheimer's Disease

mechanism · 4024 words

JAK-STAT Signaling Pathway in Neurodegeneration

mechanism · 3502 words

Pathway Diagram

graph TD
    SOCS1["<b>SOCS1</b>"]
    Ms{"Ms"}
    SOCS1 -->|"associated with"| Ms
    Carcinoma{"Carcinoma"}
    SOCS1 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    SOCS1 -->|"activates"| Cancer
    Tumor{"Tumor"}
    SOCS1 -->|"expressed in"| Tumor
    Lymphoma{"Lymphoma"}
    SOCS1 -->|"associated with"| Lymphoma
    SOCS1 -->|"therapeutic target"| Ms
    SOCS1 -->|"therapeutic target"| Tumor
    PPARGC1A["PPARGC1A"]
    SOCS1 -->|"associated with"| PPARGC1A
    Insulin_Signaling(["Insulin Signaling"])
    SOCS1 -->|"associated with"| Insulin_Signaling
    CANCER["CANCER"]
    SOCS1 -->|"activates"| CANCER
    Epigenetic(["Epigenetic"])
    SOCS1 -->|"activates"| Epigenetic
    NOTCH2["NOTCH2"]
    SOCS1 -->|"associated with"| NOTCH2
    FAS["FAS"]
    FAS -->|"associated with"| SOCS1
    FASN["FASN"]
    FASN -->|"associated with"| SOCS1
    EP300["EP300"]
    EP300 -->|"expressed in"| SOCS1
    BCL2["BCL2"]
    BCL2 -->|"associated with"| SOCS1
    TP53["TP53"]
    TP53 -->|"therapeutic target"| SOCS1
    TET2["TET2"]
    TET2 -->|"associated with"| SOCS1
    SGK1["SGK1"]
    SGK1 -->|"associated with"| SOCS1
    MYD88["MYD88"]
    MYD88 -->|"associated with"| SOCS1
    style SOCS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

TargetRelationTypeStr
JAK/STATinhibitspathway0.80
Msassociated_withdisease0.65
Carcinomaactivatesdisease0.65
Canceractivatesdisease0.65
Tumorexpressed_indisease0.65

Incoming (30)

SourceRelationTypeStr
Curcuminupregulatesdrug0.80
FASassociated_withgene0.60
FASNassociated_withgene0.60
EP300expressed_ingene0.60
BCL2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found