gene

SOCS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOCS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

3Analyses

50Outgoing

31Incoming

0Experiments

3Debates

Summary

SOCS1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 36 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	Suppressor of Cytokine Signaling 1
Chromosome	16p13.13
Protein Type	SOCS family negative regulator
Function	is a critical negative regulator of the JAK-STAT signaling pathway.
Primary Expression	Immune cells, neurons, astrocytes, microglia, widespread
Pathways	JAK-STAT signaling
UniProt ID	O35744
NCBI Gene ID	8651
Ensembl ID	ENSG00000185338
OMIM	603597
Associated Diseases	Lymphoma, Ms
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, ANXIETY, APP, APP/PS1
KG Connections	89 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SOCS1 — AlphaFold O35744 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SOCS1 Gene

gene · 1702 words

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Pathway Diagram

graph TD
    SOCS1["SOCS1"]
    Ms{"Ms"}
    SOCS1 -->|"associated with"| Ms
    Carcinoma{"Carcinoma"}
    SOCS1 -->|"activates"| Carcinoma
    Cancer{"Cancer"}
    SOCS1 -->|"activates"| Cancer
    Tumor{"Tumor"}
    SOCS1 -->|"expressed in"| Tumor
    Lymphoma{"Lymphoma"}
    SOCS1 -->|"associated with"| Lymphoma
    SOCS1 -->|"therapeutic target"| Ms
    SOCS1 -->|"therapeutic target"| Tumor
    PPARGC1A["PPARGC1A"]
    SOCS1 -->|"associated with"| PPARGC1A
    Insulin_Signaling(["Insulin Signaling"])
    SOCS1 -->|"associated with"| Insulin_Signaling
    CANCER["CANCER"]
    SOCS1 -->|"activates"| CANCER
    Epigenetic(["Epigenetic"])
    SOCS1 -->|"activates"| Epigenetic
    NOTCH2["NOTCH2"]
    SOCS1 -->|"associated with"| NOTCH2
    FAS["FAS"]
    FAS -->|"associated with"| SOCS1
    FASN["FASN"]
    FASN -->|"associated with"| SOCS1
    EP300["EP300"]
    EP300 -->|"expressed in"| SOCS1
    BCL2["BCL2"]
    BCL2 -->|"associated with"| SOCS1
    TP53["TP53"]
    TP53 -->|"therapeutic target"| SOCS1
    TET2["TET2"]
    TET2 -->|"associated with"| SOCS1
    SGK1["SGK1"]
    SGK1 -->|"associated with"| SOCS1
    MYD88["MYD88"]
    MYD88 -->|"associated with"| SOCS1
    style SOCS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (58)

Target	Relation	Type	Str
JAK/STAT	inhibits	pathway	0.80
inflammatory signaling	inhibits	pathway	0.70
Type I interferon	inhibits	process	0.70
Alzheimer	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Anxiety	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Inflammation	activates	disease	0.65
Differentiation	activates	pathway	0.60
Insulin Signaling	associated_with	pathway	0.60
Ras	inhibits	protein	0.60
PPARGC1A	associated_with	gene	0.60
Collagen	inhibits	protein	0.60
Notch	associated_with	pathway	0.60
INFLAMMATION	activates	gene	0.60
P62	regulates	gene	0.60
CEBPB	causes	gene	0.60
Autophagy	causes	pathway	0.60
JAK1	activates	gene	0.60
STAT6	activates	gene	0.60
IL1B	inhibits	gene	0.60
FOSB	inhibits	gene	0.60
APP	inhibits	gene	0.60
CANCER	activates	gene	0.60
Epigenetic	activates	pathway	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
Autophagy	therapeutic_target	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
JAK	inhibits	gene	0.60
NOTCH2	associated_with	gene	0.60
WNT	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
APP/PS1	inhibits	gene	0.60
Wnt	inhibits	pathway	0.60
Jak-Stat	inhibits	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
JAK-STAT signaling	participates_in	pathway	0.60
AND	inhibits	gene	0.60
ANXIETY	inhibits	gene	0.60

Incoming (31)

Source	Relation	Type	Str
miR-155	inhibits	gene	0.90
Curcumin	upregulates	drug	0.80
MIR155 inhibition	restores	drug	0.70
FASN	associated_with	gene	0.60
EP300	expressed_in	gene	0.60
BCL2	associated_with	gene	0.60
TP53	therapeutic_target	gene	0.60
TET2	associated_with	gene	0.60
EGR1	inhibits	gene	0.60
FAS	associated_with	gene	0.60
JAK2	activates	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
JAK	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
APP/PS1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
JAK1	activates	gene	0.60
AUTOPHAGY	causes	gene	0.60
GENES	associated_with	gene	0.60
SGK1	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
ATG5	activates	gene	0.60
SQSTM1	regulates	gene	0.60
IL1B	inhibits	gene	0.60
FOSB	inhibits	gene	0.60
STAT6	inhibits	gene	0.60
JAK2	inhibits	gene	0.60
JAK1	inhibits	gene	0.60
PPARGC1A	associated_with	gene	0.60
AND	inhibits	gene	0.60
STAT3	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning SOCS1 in their description or question text

No additional research found