Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SOCS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SOCS1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Cancer, Carcinoma. Connected to 36 entities in the SciDEX knowledge graph.
| Gene Symbol | SOCS1 |
| Aliases | JAB, SSI-1, TIPID, SOCS-1 |
| Chromosome | 16p13.13 |
| Protein Type | SOCS family negative regulator |
| Function | is a critical negative regulator of the JAK-STAT signaling pathway. |
| Primary Expression | Immune cells, neurons, astrocytes, microglia, widespread |
| Pathways | JAK-STAT signaling |
| UniProt ID | O35744 |
| NCBI Gene ID | 8651 |
| Ensembl ID | ENSG00000185338 |
| OMIM | 603597 |
| GeneCards | SOCS1 |
| Human Protein Atlas | SOCS1 |
| Gene Name | Suppressor of Cytokine Signaling 1 |
| Protein Class | SOCS family negative regulator |
| Associated Diseases | Lymphoma, Ms |
| Interactions | JAK1, STAT6, STAT1, IL1B, FOSB, APP |
| KG Connections | 86 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SOCS1["<b>SOCS1</b>"]
Ms{"Ms"}
SOCS1 -->|"associated with"| Ms
Carcinoma{"Carcinoma"}
SOCS1 -->|"activates"| Carcinoma
Cancer{"Cancer"}
SOCS1 -->|"activates"| Cancer
Tumor{"Tumor"}
SOCS1 -->|"expressed in"| Tumor
Lymphoma{"Lymphoma"}
SOCS1 -->|"associated with"| Lymphoma
SOCS1 -->|"therapeutic target"| Ms
SOCS1 -->|"therapeutic target"| Tumor
PPARGC1A["PPARGC1A"]
SOCS1 -->|"associated with"| PPARGC1A
Insulin_Signaling(["Insulin Signaling"])
SOCS1 -->|"associated with"| Insulin_Signaling
CANCER["CANCER"]
SOCS1 -->|"activates"| CANCER
Epigenetic(["Epigenetic"])
SOCS1 -->|"activates"| Epigenetic
NOTCH2["NOTCH2"]
SOCS1 -->|"associated with"| NOTCH2
FAS["FAS"]
FAS -->|"associated with"| SOCS1
FASN["FASN"]
FASN -->|"associated with"| SOCS1
EP300["EP300"]
EP300 -->|"expressed in"| SOCS1
BCL2["BCL2"]
BCL2 -->|"associated with"| SOCS1
TP53["TP53"]
TP53 -->|"therapeutic target"| SOCS1
TET2["TET2"]
TET2 -->|"associated with"| SOCS1
SGK1["SGK1"]
SGK1 -->|"associated with"| SOCS1
MYD88["MYD88"]
MYD88 -->|"associated with"| SOCS1
style SOCS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| JAK/STAT | inhibits | pathway | 0.80 |
| Ms | associated_with | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Lymphoma | associated_with | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Anxiety | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| PPARGC1A | associated_with | gene | 0.60 |
| NOTCH2 | associated_with | gene | 0.60 |
| NOTCH1 | therapeutic_target | gene | 0.60 |
| CHOP | therapeutic_target | gene | 0.60 |
| CEBPB | causes | gene | 0.60 |
| P62 | regulates | gene | 0.60 |
| JAK1 | activates | gene | 0.60 |
| STAT6 | activates | gene | 0.60 |
| STAT1 | inhibits | gene | 0.60 |
| IL1B | inhibits | gene | 0.60 |
| FOSB | inhibits | gene | 0.60 |
| APP | inhibits | gene | 0.60 |
| EGR1 | inhibits | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| STAT1 | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| Insulin Signaling | associated_with | pathway | 0.60 |
| CANCER | activates | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Notch | associated_with | pathway | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| Autophagy | causes | pathway | 0.60 |
| Differentiation | activates | pathway | 0.60 |
| AUTOPHAGY | therapeutic_target | gene | 0.60 |
| Autophagy | therapeutic_target | pathway | 0.60 |
| Nf-Κb | inhibits | pathway | 0.60 |
| JAK | inhibits | gene | 0.60 |
| ANXIETY | inhibits | gene | 0.60 |
| WNT | inhibits | gene | 0.60 |
| EXERCISE | inhibits | gene | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| GENES | inhibits | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| APP/PS1 | inhibits | gene | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Curcumin | upregulates | drug | 0.80 |
| FAS | associated_with | gene | 0.60 |
| FASN | associated_with | gene | 0.60 |
| EP300 | expressed_in | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| TP53 | therapeutic_target | gene | 0.60 |
| TET2 | associated_with | gene | 0.60 |
| SGK1 | associated_with | gene | 0.60 |
| MYD88 | associated_with | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| JAK1 | inhibits | gene | 0.60 |
| STAT6 | inhibits | gene | 0.60 |
| JAK2 | inhibits | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| PPARGC1A | associated_with | gene | 0.60 |
| EGR1 | inhibits | gene | 0.60 |
| IL1B | inhibits | gene | 0.60 |
| FOSB | inhibits | gene | 0.60 |
| JAK1 | activates | gene | 0.60 |
| JAK2 | activates | gene | 0.60 |
| AUTOPHAGY | causes | gene | 0.60 |
| ASTROCYTE | therapeutic_target | gene | 0.60 |
| JAK | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| NF-ΚB | inhibits | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| APP/PS1 | inhibits | gene | 0.60 |
| WNT | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||