Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCND2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Potassium voltage-gated channel gene KCND2 (Kv4.2) in neurodegeneration and epilepsy
| Gene Symbol | KCND2 |
| Full Name | Potassium Voltage-Gated Channel Subfamily D Member 2 |
| Aliases | Kv4.2, Shaw2 |
| Chromosome | 7q31.2 |
| Function | Mechanism |
| Subcellular Localization | dendritic shafts where they shape excitatory postsynaptic potentials, regulate backpropagation of action potentials, and |
| Molecular Weight | 72 kDa |
| Amino Acids | 647 aa |
| Exons | 7 |
| Pathways | Effect |
| UniProt ID | Q9NZV8 |
| NCBI Gene ID | 8936 |
| Ensembl ID | ENSG00000163637 |
| OMIM | 605721 |
| GeneCards | KCND2 |
| Human Protein Atlas | KCND2 |
| Associated Diseases | Epilepsy, glioblastoma |
| Interactions | GBM, NEURON, GLIOBLASTOMA, AND, CANCER, OLIGODENDROCYTE |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCND2["<b>KCND2</b>"]
Oligodendrocyte_Progenitor_Cel["Oligodendrocyte Progenitor Cells"]
KCND2 -->|"expressed_in"| Oligodendrocyte_Progenitor_Cel
Neuronal_Excitability["Neuronal Excitability"]
KCND2 -->|"modulates"| Neuronal_Excitability
Glioblastoma{"Glioblastoma"}
KCND2 -->|"activates"| Glioblastoma
Epilepsy{"Epilepsy"}
KCND2 -->|"associated_with"| Epilepsy
Cancer{"Cancer"}
KCND2 -->|"activates"| Cancer
Tumor{"Tumor"}
KCND2 -->|"activates"| Tumor
OLIGODENDROCYTE(["OLIGODENDROCYTE"])
OLIGODENDROCYTE -->|"activates"| KCND2
CANCER(["CANCER"])
CANCER -->|"activates"| KCND2
EPILEPSY(["EPILEPSY"])
EPILEPSY -->|"associated_with"| KCND2
GBM(["GBM"])
GBM -->|"activates"| KCND2
style KCND2 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Oligodendrocyte Progenitor Cells | expressed_in | cell_type | 0.95 |
| Potassium Ion Channel | encodes | protein | 0.95 |
| Neuronal Excitability | modulates | phenotype | 0.90 |
| neuronal excitability | enhances | process | 0.80 |
| Glioblastoma | activates | disease | 0.65 |
| Epilepsy | associated_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| GBM | activates | gene | 0.60 |
| Opc | associated_with | cell_type | 0.60 |
| epilepsy | interacts_with | disease | 0.60 |
| epilepsy | associated_with | disease | 0.60 |
| NEURON | activates | gene | 0.60 |
| GLIOBLASTOMA | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| Oligodendrocyte | activates | cell_type | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| CANCER | activates | gene | 0.60 |
| OLIGODENDROCYTE | activates | gene | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| glioblastoma | associated_with | disease | 0.60 |
| Oligodendrocyte | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Oligodendrocyte Progenitor Cell | expressed_in | cell_type | 0.95 |
| GBM | activates | gene | 0.60 |
| OLIGODENDROCYTE | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| EPILEPSY | associated_with | gene | 0.60 |
| GLIOBLASTOMA | activates | gene | 0.60 |
| GBM | co_expressed_with | gene | 0.50 |
| EPILEPSY | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||