Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNIP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNIP4 (Potassium Voltage-Gated Channel Interacting Protein 4) - Calcium-binding protein that modulates Kv4 potassium channels, involved in neuronal excitability and synaptic plasticity. Mutations associated with autism spectrum disorder and epilepsy.
| Gene Symbol | KCNIP4 |
| Full Name | KV Channel Interacting Protein 4 |
| Aliases | Potassium Voltage-Gated Channel Interacting Protein 4 |
| Chromosome | 4p15.32 |
| Function | KCNIP4 has multiple functions in neurons: |
| Amino Acids | 256 aa |
| Pathways | Synaptic Plasticity |
| UniProt ID | [Q9Y2X7](https://www.uniprot.org/uniprotkb/Q9Y2X7) |
| Ensembl ID | ENSG00000149636 |
| OMIM | 607375 |
| GeneCards | KCNIP4 |
| Human Protein Atlas | KCNIP4 |
| Kv4.2 and Kv4.3 channel regulation | KCNIP4 binds to and modulates the gating properties of Kv4.2 and Kv4.3 channels, which mediate transient outward potassium currents (Ito) in neurons[@kv4_channel_2021] |
| Neuronal excitability | By modulating Kv4 channels, KCNIP4 influences action potential repolarization and firing patterns |
| Dendritic integration | Kv4 channels in dendrites shape back-propagating action potentials and synaptic integration |
| Associated Diseases | Alzheimer |
| Interactions | NCAM2, RORA, FGF14, GRIN2A, NLGN1, NRXN1 |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KCNIP4["KCNIP4"]
Alzheimer["Alzheimer"]
ALZHEIMER["ALZHEIMER"]
APP["APP"]
NCAM2["NCAM2"]
RORA["RORA"]
FGF14["FGF14"]
GRIN2A["GRIN2A"]
NLGN1["NLGN1"]
SYNAPSE["SYNAPSE"]
Synaptic_Plasticity["Synaptic Plasticity"]
Neuron["Neuron"]
NRXN1["NRXN1"]
RORB["RORB"]
GENES["GENES"]
neurodegeneration["neurodegeneration"]
KCNIP4 -->|"activates"| Alzheimer
KCNIP4 -->|"activates"| ALZHEIMER
KCNIP4 -->|"regulates"| APP
KCNIP4 -->|"activates"| NCAM2
KCNIP4 -->|"activates"| RORA
KCNIP4 -->|"activates"| FGF14
KCNIP4 -->|"activates"| GRIN2A
KCNIP4 -->|"activates"| NLGN1
KCNIP4 -->|"activates"| SYNAPSE
KCNIP4 -->|"activates"| Synaptic_Plasticity
KCNIP4 -->|"activates"| Neuron
NRXN1 -->|"activates"| KCNIP4
RORB -->|"activates"| KCNIP4
ALZHEIMER -->|"activates"| KCNIP4
GENES -->|"activates"| KCNIP4
GRIN2A -->|"activates"| KCNIP4
NCAM2 -->|"activates"| KCNIP4
KCNIP4 -->|"implicated_in"| neurodegeneration
style KCNIP4 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | activates | disease | 0.65 |
| APP | regulates | gene | 0.60 |
| NCAM2 | activates | gene | 0.60 |
| RORA | activates | gene | 0.60 |
| FGF14 | activates | gene | 0.60 |
| GRIN2A | activates | gene | 0.60 |
| NLGN1 | activates | gene | 0.60 |
| NRXN1 | activates | gene | 0.60 |
| RORB | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| SYNAPSE | activates | gene | 0.60 |
| Synaptic Plasticity | activates | pathway | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| Actin | activates | protein | 0.60 |
| Fgf | activates | protein | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| Prefrontal Cortex | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| NCAM2 | co_expressed_with | gene | 0.50 |
| NRG3 | co_expressed_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NRXN1 | activates | gene | 0.60 |
| RORB | activates | gene | 0.60 |
| APP | regulates | gene | 0.60 |
| FGF14 | activates | gene | 0.60 |
| RORA | activates | gene | 0.60 |
| SYNAPSE | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| GRIN2A | activates | gene | 0.50 |
| NCAM2 | activates | gene | 0.50 |
| late | activates | disease | 0.50 |
| FGF14 | co_expressed_with | gene | 0.50 |
| GRIN2A | co_expressed_with | gene | 0.50 |
| ALZHEIMER | activates | gene | 0.50 |
| GENES | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||