gene

GRIN2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIN2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

144Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

Summary

GRIN2A encodes the NMDA receptor subunit GluN2A (NR2A), critical for synaptic plasticity, learning, and memory. Mutations cause neurodevelopmental disorders; dysregulation implicated in Alzheimer's, Parkinson's, and other neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	GRIN2A
Aliases	NMDA Receptor Subunit 2A
Function	regulation implicated in Alzheimer's
Primary Expression	Prefrontal Cortex, Cortex, Hippocampus
Molecular Weight	180 kDa
Amino Acids	838 aa
Pathways	NF-κB
GeneCards	GRIN2A
Human Protein Atlas	GRIN2A
GRIN1	Subunit heterotetramerization
DLG4 (PSD-95)	PDZ domain binding
CaMKII	Kinase substrate
SRC	Tyrosine phosphorylation
DARP32	Scaffold binding
Homer	Proline-rich motif binding
Associated Diseases	Alzheimer, schizophrenia
Known Drugs/Compounds	GW201
Interactions	KCNIP4, NLGN1, AQP4, NCAM2, APP, RORB
KG Connections	144 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GRIN2A["GRIN2A"]
    Pyroptosis["Pyroptosis"]
    Necroptosis["Necroptosis"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    PVALB["PVALB"]
    SNAP25["SNAP25"]
    Apoptosis["Apoptosis"]
    Endothelial["Endothelial"]
    Neuron["Neuron"]
    Astrocyte["Astrocyte"]
    NLGN1["NLGN1"]
    Synaptic_Plasticity["Synaptic Plasticity"]
    AQP4["AQP4"]
    AQUAPORIN_4["AQUAPORIN-4"]
    PYROPTOSIS["PYROPTOSIS"]
    SLC17A7["SLC17A7"]
    SLC17A6["SLC17A6"]
    GRIN2A -->|"therapeutic_tar"| Pyroptosis
    GRIN2A -->|"therapeutic_tar"| Necroptosis
    GRIN2A -->|"therapeutic_tar"| Dementia
    GRIN2A -->|"therapeutic_tar"| Alzheimer
    GRIN2A -->|"activates"| Alzheimer
    GRIN2A -->|"biomarker_for"| PVALB
    GRIN2A -->|"biomarker_for"| SNAP25
    GRIN2A -->|"therapeutic_tar"| Apoptosis
    GRIN2A -->|"therapeutic_tar"| Endothelial
    GRIN2A -->|"therapeutic_tar"| Neuron
    GRIN2A -->|"therapeutic_tar"| Astrocyte
    GRIN2A -->|"activates"| NLGN1
    GRIN2A -->|"activates"| Synaptic_Plasticity
    GRIN2A -->|"activates"| Neuron
    GRIN2A -->|"activates"| AQP4
    GRIN2A -->|"activates"| AQUAPORIN_4
    GRIN2A -->|"activates"| Astrocyte
    PYROPTOSIS -->|"therapeutic_tar"| GRIN2A
    SLC17A7 -->|"biomarker_for"| GRIN2A
    SLC17A6 -->|"biomarker_for"| GRIN2A
    style GRIN2A fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (96)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
calcium overload	mediates	process	0.90
Sleep Disorder	activates	disease	0.65
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
PVALB	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
NLGN1	activates	gene	0.60
AQP4	activates	gene	0.60
GAD1	biomarker_for	gene	0.60
SLC17A7	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
NCAM2	activates	gene	0.60
APP	activates	gene	0.60
RORB	activates	gene	0.60
FGF14	activates	gene	0.60
RORA	activates	gene	0.60
NRXN1	activates	gene	0.60
CALCINEURIN	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
Rb	activates	protein	0.60
NMDAR	associated_with	gene	0.60
schizophrenia	associated_with	disease	0.60
Apoptosis	therapeutic_target	pathway	0.60
Endothelial	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
Synaptic Plasticity	activates	pathway	0.60
Neuron	activates	cell_type	0.60
AQUAPORIN-4	activates	gene	0.60
Astrocyte	activates	cell_type	0.60
HUB GENES	biomarker_for	gene	0.60
RNA	expressed_in	gene	0.60
PYROPTOSIS	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
AND	biomarker_for	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
GENES	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60

Incoming (48)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
GW201	modulates	compound	0.95
SLC17A7	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
SYN2	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
NRXN1	activates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
NCAM2	activates	gene	0.60
RORA	activates	gene	0.60
FGF14	activates	gene	0.60
NEPRILYSIN	activates	gene	0.60
NLGN1	activates	gene	0.60
AQP4	activates	gene	0.60
SNAP25	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
AMYLOID	activates	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
AQUAPORIN-4	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
HUB GENES	biomarker_for	gene	0.60
RNA	expressed_in	gene	0.60
ASTROCYTE	expressed_in	cell_type	0.60
ASTROCYTES	expressed_in	cell_type	0.60
RORB	activates	gene	0.50
SLC17A6	associated_with	gene	0.50
SYN2	associated_with	gene	0.50
SNAP25	associated_with	gene	0.50
late	activates	disease	0.50
FGF14	co_expressed_with	gene	0.50
ALZHEIMER	activates	gene	0.50
GENES	interacts_with	gene	0.50
slc32a1	associated_with	gene	0.50
ASTROCYTES	activates	cell_type	0.35
benchmark_ot_ad_answer_key:GRIN2A	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GRIN2A

Understanding Entity Pages

Summary

Wiki Pages (21)

GRIN2A Gene

calcium-dysregulation-comparison

Excitotoxicity in Neurodegeneration

Excitotoxicity Pathway

PTBP2 - Polypyrimidine Tract Binding Protein 2

Ion Channel Dysfunction in Alzheimer's Disease

SETD1B

Calcium Dysregulation to Excitotoxicity Pathway

LIN7B — Lin-7 Homolog B

Calcium Dysregulation in Neurodegenerative Diseases

GRIN1 — NMDA Receptor Subunit 1

RNA Splicing Defects in Neurodegeneration

Glutamate Excitotoxicity Pathway in Neurodegeneration

GRIN2D Protein

setd1a

Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis and Enhancement

dlgh2-protein

LCK Protein (Lymphocyte-Specific Protein Tyrosine Kinase)

GRIN2A Protein