gene

RORB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RORB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

1Analyses

50Outgoing

33Incoming

0Experiments

1Debates

Summary

RAR-Related Orphan Receptor Beta - a nuclear receptor involved in circadian rhythm, brain development, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	RORB
Full Name	RAR-Related Orphan Receptor Beta
Chromosome	9q21.2
Protein Family	Nuclear receptor, ROR subfamily
Protein Type	Receptor
Function	encodes a nuclear receptor protein that plays critical roles in circadian rhythm regulation, brain development, neuronal differentiation, and synaptic plasticity.
Primary Expression	Brain (cortex, hippocampus, cerebellum, basal ganglia)
Amino Acids	459 aa
Pathways	Circadian Rhythm, Nf-Κb
UniProt ID	Q00978
NCBI Gene ID	5876
Ensembl ID	ENSG00000143163
OMIM	601925
GeneCards	RORB
Human Protein Atlas	RORB
Associated Diseases	Aging, Alzheimer
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, APP, Fgf, FGF14
KG Connections	89 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RORB — AlphaFold Q00978 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RORB Gene

gene · 1848 words

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Pathway Diagram

graph TD
    RORB["RORB"]
    Fibrosis{"Fibrosis"}
    RORB -->|"regulates"| Fibrosis
    Diabetes{"Diabetes"}
    RORB -->|"regulates"| Diabetes
    Inflammation{"Inflammation"}
    RORB -->|"regulates"| Inflammation
    Nf__b(["Nf-Kappab"])
    RORB -->|"regulates"| Nf__b
    Circadian_Rhythm(["Circadian Rhythm"])
    RORB -->|"regulates"| Circadian_Rhythm
    neurodegeneration["neurodegeneration"]
    RORB -->|"implicated in"| neurodegeneration
    CRY1["CRY1"]
    CRY1 -->|"associated with"| RORB
    MYD88["MYD88"]
    MYD88 -->|"regulates"| RORB
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"regulates"| RORB
    NF__B["NF-KappaB"]
    NF__B -->|"regulates"| RORB
    CLOCK["CLOCK"]
    CLOCK -->|"associated with"| RORB
    TLR2["TLR2"]
    TLR2 -->|"regulates"| RORB
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    CIRCADIAN_RHYTHM -->|"regulates"| RORB
    style RORB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (56)

Target	Relation	Type	Str
layer 5/6 excitatory neurons	associated_with	cell_type	0.70
layer 5/6 excitatory neuron identity	biomarker_for	cell_type	0.70
Type 2 Diabetes	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Fibrosis	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Inflammation	regulates	disease	0.65
PVALB	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
Rb	expressed_in	protein	0.60
Rb	associated_with	protein	0.60
Nf-Κb	regulates	pathway	0.60
Circadian Rhythm	regulates	pathway	0.60
Neuron	activates	cell_type	0.60
ALZHEIMER	activates	gene	0.60
SYNAPSE	activates	gene	0.60
MYD88	regulates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
FGF14	activates	gene	0.60
NLGN1	activates	gene	0.60
TAU	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.60
cortex	expressed_in	brain_region	0.60
GABAergic neurons	expressed_in	cell_type	0.60
Synaptic Plasticity	activates	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
AGING	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
Actin	activates	protein	0.60
Fgf	activates	protein	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Cortex	expressed_in	brain_region	0.55
SIRT3	activates	gene	0.55
NAD+ metabolism	participates_in	pathway	0.55
excitatory neurons	expressed_in	cell_type	0.55
Prefrontal Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
oxidative stress response	participates_in	pathway	0.55
unfolded protein response	participates_in	pathway	0.55
Caudate	expressed_in	brain_region	0.55
GENES	activates	gene	0.50
PVALB	interacts_with	gene	0.50
PREFRONTAL CORTEX	expressed_in	concept	0.50
NUCLEUS	expressed_in	concept	0.50

Incoming (33)

Source	Relation	Type	Str
PVALB	associated_with	gene	0.60
MYD88	regulates	gene	0.60
CLOCK	associated_with	gene	0.60
TLR2	regulates	gene	0.60
CRY1	associated_with	gene	0.60
FGF14	activates	gene	0.60
KCNIP4	activates	gene	0.60
RORA	activates	gene	0.60
NLGN1	activates	gene	0.60
TAU	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
NEURON	associated_with	gene	0.60
NRXN1	activates	gene	0.60
GRIN2A	activates	gene	0.60
NCAM2	activates	gene	0.60
APP	activates	gene	0.60
PVALB	interacts_with	gene	0.60
AGING	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
RNA	associated_with	gene	0.60
TAU PATHOLOGY	associated_with	gene	0.60
GENES	associated_with	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NRXN1	co_expressed_with	protein	0.50
RORA	co_expressed_with	gene	0.50
NEURON	co_discussed	gene	0.50
ALZHEIMER	expressed_in	gene	0.50
late	expressed_in	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability debate in Alzheimer's disease (SEA-AD v4)

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.710

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which cell types show the greatest vulnerability in Alzheimer's disease accordin

closed · Rounds: 4 · Score: 0.75 · 2026-04-22

Related Research

Hypotheses and analyses mentioning RORB in their description or question text

No additional research found