gene

RORB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RORB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

50Outgoing

36Incoming

Summary

RAR-Related Orphan Receptor Beta - a nuclear receptor involved in circadian rhythm, brain development, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	RORB
Full Name	RAR-Related Orphan Receptor Beta
Chromosome	9q21.2
Protein Family	Nuclear receptor, ROR subfamily
Protein Type	Receptor
Function	encodes a nuclear receptor protein that plays critical roles in circadian rhythm regulation, brain development, neuronal differentiation, and synaptic plasticity.
Primary Expression	Brain (cortex, hippocampus, cerebellum, basal ganglia)
Amino Acids	459 aa
Pathways	Circadian Rhythm, Nf-Κb
UniProt ID	Q00978
NCBI Gene ID	5876
Ensembl ID	ENSG00000143163
OMIM	601925
GeneCards	RORB
Human Protein Atlas	RORB
Associated Diseases	Aging, Alzheimer
Interactions	GRIN2A, NCAM2, NRXN1, RORA, KCNIP4, APP
KG Connections	90 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RORB — AlphaFold Q00978 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RORB["<b>RORB</b>"]
    Fibrosis{"Fibrosis"}
    RORB -->|"regulates"| Fibrosis
    Diabetes{"Diabetes"}
    RORB -->|"regulates"| Diabetes
    Inflammation{"Inflammation"}
    RORB -->|"regulates"| Inflammation
    Nf__b(["Nf-Kappab"])
    RORB -->|"regulates"| Nf__b
    Circadian_Rhythm(["Circadian Rhythm"])
    RORB -->|"regulates"| Circadian_Rhythm
    neurodegeneration["neurodegeneration"]
    RORB -->|"implicated in"| neurodegeneration
    CRY1["CRY1"]
    CRY1 -->|"associated with"| RORB
    MYD88["MYD88"]
    MYD88 -->|"regulates"| RORB
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"regulates"| RORB
    NF__B["NF-KappaB"]
    NF__B -->|"regulates"| RORB
    CLOCK["CLOCK"]
    CLOCK -->|"associated with"| RORB
    TLR2["TLR2"]
    TLR2 -->|"regulates"| RORB
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    CIRCADIAN_RHYTHM -->|"regulates"| RORB
    style RORB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
Fibrosis	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Type 2 Diabetes	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
MYD88	regulates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
FGF14	activates	gene	0.60
NLGN1	activates	gene	0.60
TAU	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
Rb	expressed_in	protein	0.60
Rb	associated_with	protein	0.60
Nf-Κb	regulates	pathway	0.60
Circadian Rhythm	regulates	pathway	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
SYNAPSE	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
Neuron	activates	cell_type	0.60
ALZHEIMER	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
AGING	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
Actin	activates	protein	0.60
Fgf	activates	protein	0.60
neurons	expressed_in	cell_type	0.60
cortex	expressed_in	brain_region	0.60
GABAergic neurons	expressed_in	cell_type	0.60
Caudate	expressed_in	brain_region	0.55
SIRT3	activates	gene	0.55
NAD+ metabolism	participates_in	pathway	0.55
excitatory neurons	expressed_in	cell_type	0.55
Prefrontal Cortex	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
oxidative stress response	participates_in	pathway	0.55
unfolded protein response	participates_in	pathway	0.55
GRIN2A	activates	gene	0.50
NCAM2	activates	gene	0.50
NRXN1	activates	protein	0.50
RORA	activates	gene	0.50
PVALB	interacts_with	gene	0.50
GENES	activates	gene	0.50

Incoming (36)

Source	Relation	Type	Str
CRY1	associated_with	gene	0.60
MYD88	regulates	gene	0.60
CLOCK	associated_with	gene	0.60
TLR2	regulates	gene	0.60
NRXN1	activates	gene	0.60
GRIN2A	activates	gene	0.60
NCAM2	activates	gene	0.60
APP	activates	gene	0.60
PVALB	associated_with	gene	0.60
FGF14	activates	gene	0.60
KCNIP4	activates	gene	0.60
RORA	activates	gene	0.60
NLGN1	activates	gene	0.60
TAU	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
PVALB	interacts_with	gene	0.60
PVALB	binds_to	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	expressed_in	gene	0.60
AGING	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
RNA	associated_with	gene	0.60
TAU PATHOLOGY	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
late	expressed_in	disease	0.50
NRXN1	co_expressed_with	protein	0.50
RORA	co_expressed_with	gene	0.50
ALZHEIMER	expressed_in	gene	0.50
NEURON	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RORB

Understanding Entity Pages

Summary

Wiki Pages (21)

RORB Gene

Claustrum Neurons

Allen Institute for Neural Dynamics

Dorsolateral Prefrontal Cortex (DLPFC) Pyramidal Neurons

Cerebellar Purkinje Cells in Motor Coordination

NGN2 (Neurogenin-2)

Cortical Layer 5 Pyramidal Neurons in Alzheimer's Disease

Cortical Layer 5 Pyramidal Neurons

Cortical Pyramidal Neurons (Layers 2/3)

Prefrontal Cortex Layer 5 Pyramidal Neurons

Layer 4 Granule Cells

Hippocampal CA2 Pyramidal Neurons

Cortical Layer 2/3 IT Neurons

Angular Gyrus Neurons

Dysgranular Insular Cortex Neurons

Posterior Cingulate Cortex Neurons

Infralimbic Cortex Pyramidal Neurons

Entorhinal Cortex Layer 2 Neurons

Supramarginal Gyrus Neurons