gene

NCAM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCAM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

31Outgoing

16Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	NCAM2
Full Name	Neural Cell Adhesion Molecule 2
Chromosome	21q21.3
Protein Type	Immunoglobulin superfamily, cell adhesion molecule
Function	is a critical member of the immunoglobulin superfamily of cell adhesion molecules, encoded by a gene located on human chromosome 21q21.
Amino Acids	827 aa
Pathways	Neuroprotection, Synaptic Plasticity, synaptic plasticity
UniProt ID	P31816
NCBI Gene ID	4685
Ensembl ID	ENSG00000154654
GeneCards	NCAM2
Human Protein Atlas	NCAM2
OMIM Entry	602431
Gene Length	~180 kb
Coding Exons	19
Associated Diseases	Alzheimer
Interactions	KCNIP4, RORA, FGF14, GRIN2A, NLGN1, APP
KG Connections	47 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCAM2 — AlphaFold P31816 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NCAM2["NCAM2"]
    Alzheimer["Alzheimer"]
    RORA["RORA"]
    FGF14["FGF14"]
    GRIN2A["GRIN2A"]
    NLGN1["NLGN1"]
    SYNAPSE["SYNAPSE"]
    Synaptic_Plasticity["Synaptic Plasticity"]
    Neuron["Neuron"]
    NRXN1["NRXN1"]
    KCNIP4["KCNIP4"]
    APP["APP"]
    NEURON["NEURON"]
    ALZHEIMER["ALZHEIMER"]
    GENES["GENES"]
    RORB["RORB"]
    neurodegeneration["neurodegeneration"]
    NCAM2 -->|"activates"| Alzheimer
    NCAM2 -->|"activates"| RORA
    NCAM2 -->|"activates"| FGF14
    NCAM2 -->|"activates"| GRIN2A
    NCAM2 -->|"activates"| NLGN1
    NCAM2 -->|"activates"| SYNAPSE
    NCAM2 -->|"activates"| Synaptic_Plasticity
    NCAM2 -->|"activates"| Neuron
    NRXN1 -->|"activates"| NCAM2
    KCNIP4 -->|"activates"| NCAM2
    APP -->|"activates"| NCAM2
    NCAM2 -->|"activates"| KCNIP4
    NCAM2 -.-|"discussed with"| NEURON
    NCAM2 -.-|"discussed with"| NRXN1
    NCAM2 -.-|"discussed with"| RORA
    ALZHEIMER -->|"activates"| NCAM2
    GENES <-->|"interacts"| NCAM2
    GRIN2A -.-|"discussed with"| NCAM2
    RORB -->|"activates"| NCAM2
    NCAM2 -->|"implicated_in"| neurodegeneration
    style NCAM2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (31)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
RORA	activates	gene	0.60
FGF14	activates	gene	0.60
GRIN2A	activates	gene	0.60
NLGN1	activates	gene	0.60
APP	activates	gene	0.60
RORB	activates	gene	0.60
NRXN1	activates	gene	0.60
Rb	activates	protein	0.60
SYNAPSE	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
Neuron	activates	cell_type	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Actin	activates	protein	0.60
Fgf	activates	protein	0.60
synaptic plasticity	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
Alzheimer	associated_with	disease	0.60
Prefrontal Cortex	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
KCNIP4	activates	gene	0.50
NRXN1	co_discussed	protein	0.50
RORA	co_discussed	gene	0.50
NRXN1	co_expressed_with	protein	0.50
NEURON	co_discussed	gene	0.50
NEURONS	activates	concept	0.50
Neuroprotection	activates	process	0.50
NRG3	co_expressed_with	protein	0.50

Incoming (16)

Source	Relation	Type	Str
NRXN1	activates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
GRIN2A	activates	gene	0.60
NLGN1	activates	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
GRIN2A	co_discussed	gene	0.50
RORB	activates	gene	0.50
late	activates	disease	0.50
FGF14	activates	gene	0.50
RORA	activates	gene	0.50
GRIN2A	co_expressed_with	gene	0.50
KCNIP4	co_expressed_with	gene	0.50
ALZHEIMER	activates	gene	0.50
GENES	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NCAM2

Understanding Entity Pages

Wiki Pages (4)

ncam2

KCNIP4