Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LEWY BODIES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | LEWY BODIES |
| Key Genes/Proteins | AMYLOID, LRRK2, ALPHA-SYNUCLEIN, TAU, TH, SORL1 |
| Related Diseases | NEURODEGENERATION, CELL DEATH, PARKINSON'S DISEASE, NEUROINFLAMMATION, ROS |
Knowledge base pages for this entity
graph TD
LEWY_BODIES["LEWY BODIES"]
LEWY_BODIES -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
LEWY_BODIES -->|"produces"| CELL_DEATH["CELL DEATH"]
SNCA["SNCA"] -.biomarker for.-> LEWY_BODIES
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"component_of"| LEWY_BODIES
Alpha_Synuclein["Alpha-Synuclein"] -->|"involved_in"| LEWY_BODIES
__synuclein["alpha-synuclein"] -->|"involved_in"| LEWY_BODIES
LRRK2["LRRK2"] -->|"involved_in"| LEWY_BODIES| Target | Relation | Type | Str |
|---|---|---|---|
| AMYLOID | protects_against | protein | 0.70 |
| AMYLOID | regulates | protein | 0.70 |
| AMYLOID | treats | protein | 0.70 |
| NEURODEGENERATION | causes | phenotype | 0.65 |
| CELL DEATH | produces | phenotype | 0.65 |
| PARKINSON'S DISEASE | interacts_with | disease | 0.65 |
| LRRK2 | interacts_with | gene | 0.65 |
| ALPHA-SYNUCLEIN | phosphorylates | protein | 0.65 |
| NEURONS | produces | cell_type | 0.65 |
| ALPHA-SYNUCLEIN | interacts_with | protein | 0.65 |
| NEURODEGENERATION | expressed_in | phenotype | 0.55 |
| DOPAMINE | expressed_in | phenotype | 0.55 |
| PARKINSON'S DISEASE | expressed_in | disease | 0.55 |
| CORTEX | associated_with | brain_region | 0.50 |
| BRAINSTEM | associated_with | brain_region | 0.50 |
| THALAMUS | associated_with | brain_region | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | interacts_with | protein | 0.65 |
| NEUROINFLAMMATION | causes | phenotype | 0.65 |
| ROS | activates | phenotype | 0.65 |
| TH | activates | gene | 0.65 |
| SORL1 | transports | gene | 0.65 |
| DEMENTIA | regulates | disease | 0.65 |
| PARKINSON'S DISEASE | participates_in | disease | 0.55 |
| ALPHA-SYNUCLEIN | participates_in | protein | 0.55 |
| ALPHA-SYNUCLEIN | expressed_in | protein | 0.55 |
| SORL1 | expressed_in | gene | 0.55 |
| CEREBRAL CORTEX | associated_with | brain_region | 0.50 |
| HIPPOCAMPUS | associated_with | brain_region | 0.50 |
| OLFACTORY BULB | associated_with | brain_region | 0.45 |
| SUBSTANTIA NIGRA | associated_with | brain_region | 0.45 |
| LOCUS COERULEUS | associated_with | brain_region | 0.45 |
| PREFRONTAL CORTEX | associated_with | brain_region | 0.45 |
| CAUDATE NUCLEUS | associated_with | brain_region | 0.45 |
| VCP | associated_with | gene | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||