concept

LYSOSOMAL FUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYSOSOMAL FUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

1Analyses

3Outgoing

28Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LYSOSOMAL FUNCTION
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LYSOSOMAL_FUNCTION["LYSOSOMAL FUNCTION"]
    LYSOSOMAL_FUNCTION -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    TFEB["TFEB"] -->|"activates"| LYSOSOMAL_FUNCTION
    CKLF["CKLF"] -->|"inhibits"| LYSOSOMAL_FUNCTION
    AMPK["AMPK"] -->|"regulates"| LYSOSOMAL_FUNCTION
    TREM2["TREM2"] -->|"regulates"| LYSOSOMAL_FUNCTION
    Lyso_ChR2["Lyso-ChR2"] -->|"modulates"| LYSOSOMAL_FUNCTION
    APOE4["APOE4"] -->|"inhibits"| LYSOSOMAL_FUNCTION
    TMEM175["TMEM175"] -->|"regulates"| LYSOSOMAL_FUNCTION

Outgoing (3)

Target	Relation	Type	Str
Alzheimer's Disease	involved_in	disease	0.90
Vandetanib-Induced Hepato-Cardiotoxicity	protects_against	phenotype	0.85
tau pathology	involved_in	phenotype	0.70

Incoming (28)

Source	Relation	Type	Str
TFEB	activates	gene	0.95
GRN	involved_in	gene	0.95
Palmitic acid	associated_with	compound	0.95
WDR91	regulates	protein	0.95
TREM2	regulates	gene	0.90
Lyso-ChR2	modulates	protein	0.90
Urolithin A	associated_with	compound	0.90
Urolithin A	associated_with	chemical	0.90
APOE4	inhibits	protein	0.90
CTSD	regulates	gene	0.90
pH disruption	associated_with	process	0.90
WDR91	regulates	protein	0.90
CKLF	inhibits	protein	0.90
AMPK	regulates	protein	0.90
TFEB	regulates	protein	0.88
Lyso-Chr2	regulates	protein	0.87
LRRK2 Inhibitors	treats	drug	0.85
MS4A4A	inhibits	gene	0.80
Lrrk2 Inhibitors	associated_with	drug	0.80
APOE4	impairs	gene	0.80
APOE4	impairs	gene	0.80
TMEM175	regulates	protein	0.75
LRRK2	modulates	protein	0.75
TMT	inhibits	drug	0.70
CTSZ	regulates	protein	0.70
TFEB	regulates	protein	0.70
Urolithin A	restores	compound	0.70
TMEM106B	modulates	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LYSOSOMAL FUNCTION

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Novel Therapy Index

Atypical Parkinsonism

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Multiple System Atrophy

Frontotemporal Dementia (FTD)

PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy

CLCN10 — Chloride Voltage-Gated Channel 10

Synucleinopathy Mechanism

Autophagy Mechanisms

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

APOC4 — Apolipoprotein C-IV

ftd-tdp-pathology

Mitophagy Pathway in Neurodegeneration

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases