TMEM106B

Understanding Entity Pages

This page aggregates everything SciDEX knows about TMEM106B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TMEM106B is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, interacts with. Associated with Aging, Als, Alzheimer. Connected to 27 entities in the SciDEX knowledge graph.

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graph TD
    TMEM106B["<b>TMEM106B</b>"]
    endosome_lysosome_function(["endosome-lysosome function"])
    TMEM106B -->|"regulates"| endosome_lysosome_function
    Alzheimer{"Alzheimer"}
    TMEM106B -->|"associated with"| Alzheimer
    TMEM106B -->|"therapeutic target"| Alzheimer
    Ms{"Ms"}
    TMEM106B -->|"therapeutic target"| Ms
    Dementia{"Dementia"}
    TMEM106B -->|"therapeutic target"| Dementia
    Als{"Als"}
    TMEM106B -->|"therapeutic target"| Als
    TMEM106B -->|"associated with"| Als
    Aging{"Aging"}
    TMEM106B -->|"associated with"| Aging
    TMEM106B -->|"interacts with"| Dementia
    SIGLEC9["SIGLEC9"]
    TMEM106B -->|"associated with"| SIGLEC9
    SIRPA["SIRPA"]
    TMEM106B -->|"associated with"| SIRPA
    GRN["GRN"]
    TMEM106B -->|"associated with"| GRN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| TMEM106B
    TREM2["TREM2"]
    TREM2 -->|"associated with"| TMEM106B
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| TMEM106B
    CTSH["CTSH"]
    CTSH -->|"associated with"| TMEM106B
    FTLD["FTLD"]
    FTLD -->|"associated with"| TMEM106B
    MAPT["MAPT"]
    MAPT -->|"associated with"| TMEM106B
    style TMEM106B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0