protein

MS4A4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MS4A4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

44Outgoing

10Incoming

Summary

Page for MS4A4A Protein

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🔬 Protein Info

Gene Symbol	MS4A4A
Full Name	Membrane-Spanning 4-Domains A4A
Chromosome	11q12.2
Function	encodes a membrane protein expressed primarily in immune cells, particularly microglia and other myeloid cells.
Primary Expression	immune cells, particularly microglia and other myeloid cells
Molecular Weight	~22 kDa
Amino Acids	199 aa
Exons	6
UniProt ID	Q9H3Y1
NCBI Gene ID	246213
Ensembl ID	ENSG00000166926
OMIM	614508
GeneCards	MS4A4A
Human Protein Atlas	MS4A4A
Protein Length	199 amino acids
Associated Diseases	Alzheimer's disease, Cancer
Interactions	MS4A6A, MS4A6E, TREM2, APOE, CLU, CR1
KG Connections	54 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MS4A4A — AlphaFold Q9H3Y1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MS4A4A["<b>MS4A4A</b>"]
    TUMOR{"TUMOR"}
    MS4A4A -->|"regulates"| TUMOR
    Alzheimer_s_disease{"Alzheimer's disease"}
    MS4A4A -->|"associated_with"| Alzheimer_s_disease
    Ms{"Ms"}
    MS4A4A -.->|"inhibits"| Ms
    Als{"Als"}
    MS4A4A -->|"activates"| Als
    Alzheimer{"Alzheimer"}
    MS4A4A -->|"regulates"| Alzheimer
    Amyloid["Amyloid"]
    MS4A4A -->|"protects_against"| Amyloid
    AMYLOID(["AMYLOID"])
    AMYLOID -->|"protects_against"| MS4A4A
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"regulates"| MS4A4A
    AND(["AND"])
    AND -.->|"inhibits"| MS4A4A
    TREM2(["TREM2"])
    TREM2 -->|"expressed_in"| MS4A4A
    style MS4A4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (44)

Target	Relation	Type	Str
MS4A6A	interacts_with	gene	0.90
Microglia Phagocytosis	inhibits	process	0.85
Alzheimer's Disease	risk_factor_for	disease	0.85
Lysosomal Function	inhibits	process	0.80
TUMOR	regulates	disease	0.80
Alzheimer's disease	associated_with	disease	0.70
Ms	inhibits	disease	0.65
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	associated_with	disease	0.65
CCR8	associated_with	gene	0.60
LAG3	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
CD163	associated_with	gene	0.60
STAT5B	associated_with	gene	0.60
Il-6	associated_with	protein	0.60
Stat3	associated_with	protein	0.60
MS4A6E	interacts_with	gene	0.60
MS4A6A	regulates	gene	0.60
TREM2	regulates	gene	0.60
TREM2	interacts_with	gene	0.60
MS4A6A	expressed_in	gene	0.60
Amyloid	protects_against	pathway	0.60
COMPLEMENT	associated_with	gene	0.60
KRAS	associated_with	gene	0.60
HEDGEHOG	associated_with	gene	0.60
NOTCH	associated_with	gene	0.60
PFKFB3	associated_with	gene	0.60
PD-L1	associated_with	gene	0.60
Nf-Κb	associated_with	pathway	0.60
Pi3K/Akt	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Epithelial	associated_with	cell_type	0.60
Macrophage	associated_with	cell_type	0.60
Akt	associated_with	protein	0.60
Ras	associated_with	protein	0.60
Pi3K	associated_with	protein	0.60
Alzheimer's disease	regulates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
Alzheimer's disease	expressed_in	disease	0.60
microglia	expressed_in	cell_type	0.55
macrophages	expressed_in	cell_type	0.55

Incoming (10)

Source	Relation	Type	Str
TREM2	expressed_in	gene	0.60
APOE	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
AMYLOID	protects_against	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	inhibits	gene	0.60
MICROGLIA	causes	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MS4A	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MS4A4A

Understanding Entity Pages

Summary

Wiki Pages (21)

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

Alzheimer's Disease

TREM2 Microglial Signaling Pathway in Neurodegeneration

genetics

TYROBP/DAP12 Microglia Signaling Pathway in Alzheimer's Disease

TREM2 Microglia Pathway in Alzheimer's Disease

MS4A6A Gene

MS4A6E Gene

MS4A4A-MS4A6A Cooperation in TREM2 Regulation

MS4A7 Gene — Membrane-Spanning 4-Domains A7

MS4A1 — Membrane Spanning 4-Domains A1 (CD20)

Amyloid-Beta Clearance Therapeutic Pathways

MS4A3 Protein

MS4A3 Gene

MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal Chain

MS4A4A Protein

MS4A1 Protein

MS4A4E Gene - Membrane-Spanning 4-Domains A4E

MS4A6A Protein