concept

CKLF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CKLF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

42Outgoing

3Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CKLF
Key Genes/Proteins	SQSTM1, DNM1L, PINK1, PRKN
Related Diseases	microglial activation, neuroinflammation
Related Pathways	mitophagy, lysosomal function

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CKLF["CKLF"]
    CKLF -->|"causes"| Microglial_Activation["Microglial Activation"]
    CKLF -->|"causes"| microglial_activation["microglial activation"]
    CKLF -->|"inhibits"| mitophagy["mitophagy"]
    CKLF -->|"contributes to"| SQSTM1["SQSTM1"]
    CKLF -->|"causes"| neuroinflammation["neuroinflammation"]
    CKLF -->|"inhibits"| lysosomal_function["lysosomal function"]
    CKLF -->|"causes"| Defective_Mitophagy["Defective Mitophagy"]
    CKLF -->|"upregulates"| DNM1L["DNM1L"]

Outgoing (42)

Target	Relation	Type	Str
Microglial Activation	causes	process	0.95
MICROGLIA	activates	cell_type	0.95
NEUROINFLAMMATION	promotes	process	0.95
microglial activation	causes	phenotype	0.90
mitophagy	inhibits	pathway	0.90
SQSTM1	contributes_to	protein	0.90
neuroinflammation	causes	phenotype	0.90
lysosomal function	inhibits	pathway	0.90
Defective Mitophagy	causes	process	0.90
AUTOPHAGY	upregulates	process	0.90
MITOCHONDRIA	causes	cell_type	0.90
MITOPHAGY	triggers	process	0.90
DNM1L	upregulates	gene	0.85
PINK1	upregulates	gene	0.85
PRKN	upregulates	gene	0.85
OPTN	upregulates	gene	0.85
SQSTM1	upregulates	gene	0.85
PARKIN	upregulates	entity	0.85
LC3	upregulates	entity	0.85
CYTOKINES	upregulates	protein	0.85
DNM1L	contributes_to	protein	0.80
PINK1	contributes_to	protein	0.80
PRKN	contributes_to	protein	0.80
OPTN	contributes_to	protein	0.80
BECN1	contributes_to	protein	0.80
MAP1LC3B	contributes_to	protein	0.80
AIF1	contributes_to	protein	0.80
BECN1	upregulates	gene	0.80
MAP1LC3B	upregulates	gene	0.80
mitochondrial dysfunction	induces	process	0.80
MITOPHAGY	induces	process	0.70
CKLF1	activates	gene	0.60
DNM1L	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
SQSTM1	targets	gene	0.60
neuroinflammation	activates	disease	0.60
microglia	expressed_in	cell_type	0.55

Incoming (3)

Source	Relation	Type	Str
Neuroinflammation	associated_with	process	0.85
BECN1	activates	gene	0.60
AIF1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CKLF

Understanding Entity Pages

Wiki Pages (5)

Parkin Protein

PRKN — Parkin RBR E3 Ubiquitin Protein Ligase

AIF1 Gene