Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MEF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Soft Tissue Sarcoma | biomarker_for | disease | 0.80 |
| PI3K | targets | gene | 0.60 |
| PTEN | inhibits | gene | 0.60 |
| PI3K | inhibits | gene | 0.60 |
| MEF2C | activates | gene | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:MEF2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HDAC4 | interacts_with | protein | 0.95 |
| HDAC7 | interacts_with | protein | 0.90 |
| AKT | modulates | protein | 0.85 |
| PI3K | modulates | gene | 0.85 |
| PI3K/AKT Pathway | modulates | pathway | 0.85 |
| AKT | phosphorylates | gene | 0.80 |
| PI3K/AKT | regulates | pathway | 0.80 |
| PI3K/Akt | regulates | pathway | 0.70 |
| PTEN | regulates | gene | 0.70 |
| HDAC4 | targets | gene | 0.60 |
| HDAC4 | inhibits | gene | 0.60 |
| HDAC | associated_with | gene | 0.60 |
| HDAC | targets | gene | 0.60 |
| HDAC | inhibits | gene | 0.60 |
| benchmark_ot_ad_answer_key:MEF2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| MEF2C-Dependent Synaptic Gene Regulation | 0.578 | neurodegeneration | What molecular mechanisms mediate HDAC9' |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||