gene

MID49

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MID49: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections
0Hypotheses
0Analyses
25Outgoing
14Incoming

Summary

MID49 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, interacts with. Associated with Aging, Als, Ms. Connected to 34 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolMID49
Chromosome5q31.2
Functionis a mitochondrial outer membrane protein that plays a critical role in regulating mitochondrial dynamics.
Molecular Weight49 kDa
Amino Acids452 aa
PathwaysMitophagy
Ensembl IDENSG00000156535
GeneCardsMID49
Human Protein AtlasMID49
Mitochondrial quality controlRemoving damaged mitochondria through mitophagy
Energy distributionEnsuring equitable distribution of mitochondria throughout neurons
DNA maintenanceFacilitating mitochondrial DNA (mtDNA) mixing and repair
Apoptosis regulationControlling cytochrome c release
Associated DiseasesAls, Parkinson
InteractionsMFF, MID51, MIRO1, UBIQUITIN, DRP1, AMPK
KG Connections39 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

mid49

gene · 2058 words

Mitochondrial Quality Control

mechanism · 5069 words

Mitochondria

entity · 3769 words

Mitochondria in Neurodegeneration

mechanism · 3404 words

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

mechanism · 3314 words

mitochondrial-dynamics

mechanism · 3276 words

Pathway Diagram

graph TD
    MID49["<b>MID49</b>"]
    Aging{"Aging"}
    MID49 -->|"regulates"| Aging
    Ms{"Ms"}
    MID49 -->|"activates"| Ms
    Parkinson{"Parkinson"}
    MID49 -->|"associated with"| Parkinson
    Als{"Als"}
    MID49 -->|"associated with"| Als
    MFF["MFF"]
    MID49 -->|"interacts with"| MFF
    MID51["MID51"]
    MID49 -->|"interacts with"| MID51
    MIRO1["MIRO1"]
    MID49 -->|"interacts with"| MIRO1
    TOMM20["TOMM20"]
    MID49 -->|"regulates"| TOMM20
    MID49 -->|"associated with"| MFF
    DRP1["DRP1"]
    MID49 -->|"associated with"| DRP1
    UBIQUITIN["UBIQUITIN"]
    MID49 -->|"activates"| UBIQUITIN
    AMPK["AMPK"]
    MID49 -->|"activates"| AMPK
    DRP1 -->|"interacts with"| MID49
    TOMM20 -->|"regulates"| MID49
    MAX["MAX"]
    MAX -->|"regulates"| MID49
    MIRO1 -->|"interacts with"| MID49
    MID51 -->|"interacts with"| MID49
    MFF -->|"interacts with"| MID49
    AMPK -->|"activates"| MID49
    DRP1 -->|"associated with"| MID49
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| MID49
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"associated with"| MID49
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"regulates"| MID49
    MFF -->|"associated with"| MID49
    style MID49 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

TargetRelationTypeStr
Agingregulatesdisease0.65
Msactivatesdisease0.65
Parkinsonassociated_withdisease0.65
Alsassociated_withdisease0.65
MFFinteracts_withgene0.60

Incoming (14)

SourceRelationTypeStr
DRP1interacts_withgene0.60
TOMM20regulatesgene0.60
MAXregulatesgene0.60
MIRO1interacts_withgene0.60
MID51interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found