Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MID49: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MID49 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, interacts with. Associated with Aging, Als, Ms. Connected to 34 entities in the SciDEX knowledge graph.
| Gene Symbol | MID49 |
| Chromosome | 5q31.2 |
| Function | is a mitochondrial outer membrane protein that plays a critical role in regulating mitochondrial dynamics. |
| Molecular Weight | 49 kDa |
| Amino Acids | 452 aa |
| Pathways | Mitophagy |
| Ensembl ID | ENSG00000156535 |
| GeneCards | MID49 |
| Human Protein Atlas | MID49 |
| Mitochondrial quality control | Removing damaged mitochondria through mitophagy |
| Energy distribution | Ensuring equitable distribution of mitochondria throughout neurons |
| DNA maintenance | Facilitating mitochondrial DNA (mtDNA) mixing and repair |
| Apoptosis regulation | Controlling cytochrome c release |
| Associated Diseases | Als, Parkinson |
| Interactions | MFF, MID51, MIRO1, UBIQUITIN, DRP1, AMPK |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MID49["<b>MID49</b>"]
Aging{"Aging"}
MID49 -->|"regulates"| Aging
Ms{"Ms"}
MID49 -->|"activates"| Ms
Parkinson{"Parkinson"}
MID49 -->|"associated with"| Parkinson
Als{"Als"}
MID49 -->|"associated with"| Als
MFF["MFF"]
MID49 -->|"interacts with"| MFF
MID51["MID51"]
MID49 -->|"interacts with"| MID51
MIRO1["MIRO1"]
MID49 -->|"interacts with"| MIRO1
TOMM20["TOMM20"]
MID49 -->|"regulates"| TOMM20
MID49 -->|"associated with"| MFF
DRP1["DRP1"]
MID49 -->|"associated with"| DRP1
UBIQUITIN["UBIQUITIN"]
MID49 -->|"activates"| UBIQUITIN
AMPK["AMPK"]
MID49 -->|"activates"| AMPK
DRP1 -->|"interacts with"| MID49
TOMM20 -->|"regulates"| MID49
MAX["MAX"]
MAX -->|"regulates"| MID49
MIRO1 -->|"interacts with"| MID49
MID51 -->|"interacts with"| MID49
MFF -->|"interacts with"| MID49
AMPK -->|"activates"| MID49
DRP1 -->|"associated with"| MID49
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| MID49
MITOPHAGY["MITOPHAGY"]
MITOPHAGY -->|"associated with"| MID49
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"regulates"| MID49
MFF -->|"associated with"| MID49
style MID49 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | regulates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| MFF | interacts_with | gene | 0.60 |
| MID51 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| TOMM20 | regulates | gene | 0.60 |
| MFF | associated_with | gene | 0.60 |
| DRP1 | associated_with | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| MID51 | associated_with | gene | 0.60 |
| FIS1 | associated_with | gene | 0.60 |
| MAX | regulates | gene | 0.60 |
| DRP1 | interacts_with | gene | 0.60 |
| MIRO1 | associated_with | entity | 0.60 |
| AMPK | activates | gene | 0.60 |
| Mitophagy | associated_with | pathway | 0.60 |
| AGING | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
| Proteins | associated_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DRP1 | interacts_with | gene | 0.60 |
| TOMM20 | regulates | gene | 0.60 |
| MAX | regulates | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| MID51 | interacts_with | gene | 0.60 |
| MFF | interacts_with | gene | 0.60 |
| DRP1 | associated_with | gene | 0.60 |
| MFF | associated_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| MITOPHAGY | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| MITOCHONDRIA | associated_with | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||