MAX

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MAX is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 154 entities in the SciDEX knowledge graph.

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flowchart TD
    MAX["MAX<br/>Transcription Factor"]
    
    CGAS["cGAS<br/>DNA Sensor"]
    STING["STING<br/>Innate Immunity"]
    PARP1["PARP1<br/>DNA Repair"]
    
    Neurodegeneration["Neurodegeneration<br/>Progressive Loss"]
    ALS["Amyotrophic Lateral<br/>Sclerosis (ALS)"]
    MS["Multiple Sclerosis<br/>(MS)"]
    Parkinsons["Parkinson's<br/>Disease"]
    
    Aging["Cellular<br/>Aging"]
    Autoimmune["Autoimmune<br/>Response"]
    Cancer["Cancer<br/>Development"]
    Tumor["Tumor<br/>Formation"]
    
    Inflammation["Chronic<br/>Inflammation"]
    DNA_Damage["DNA Damage<br/>Response"]
    Cell_Death["Neuronal<br/>Cell Death"]
    Therapeutic["Therapeutic<br/>Target"]
    
    MAX --|"inhibits"|--> CGAS
    MAX --|"inhibits"|--> STING
    MAX --|"inhibits"|--> PARP1
    
    CGAS --|"activates"|--> STING
    STING --|"promotes"|--> Inflammation
    PARP1 --|"responds to"|--> DNA_Damage
    
    MAX --|"regulates"|--> Aging
    MAX --|"associated with"|--> Neurodegeneration
    MAX --|"activates"|--> ALS
    MAX --|"activates"|--> MS
    MAX --|"associated with"|--> Parkinsons
    
    Inflammation --|"contributes to"|--> Neurodegeneration
    DNA_Damage --|"leads to"|--> Cell_Death
    Aging --|"promotes"|--> Neurodegeneration
    
    MAX --|"activates"|--> Autoimmune
    Autoimmune --|"triggers"|--> MS
    
    MAX --|"therapeutic target"|--> Therapeutic
    
    style MAX fill:#006494
    style PARP1 fill:#4a1a6b
    style CGAS fill:#4a1a6b
    style STING fill:#4a1a6b
    style Therapeutic fill:#1b5e20
    style Neurodegeneration fill:#5d4400
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Parkinsons fill:#ef5350
    style Inflammation fill:#ef5350
    style Cell_Death fill:#ef5350
    style Autoimmune fill:#ef5350
    style Cancer fill:#ef5350
    style Aging fill:#5d4400