gene

MAX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

209Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAX is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 154 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAX
Full Name	MAX Protein
Chromosome	14q23.3
Protein Family	bHLH-LZ Transcription Factor Family
Protein Type	Transcription Factor
Function	MYC-MAX heterodimers activate target genes
Subcellular Localization	Nuclear
Molecular Weight	18 kDa
Amino Acids	160 aa
Pathways	Tgf-Β
UniProt ID	P61275
GeneCards	MAX
Human Protein Atlas	MAX
Associated Diseases	Aging, Als, Autoimmune, Cancer, Ms
Interactions	App, AQP4, AQUAPORIN-4, ASTROCYTE, CANCER, CGAS
KG Connections	209 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MAX — AlphaFold P61275 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MAX — MAX Protein

gene · 978 words

→

MAX Protein (MAX)

protein · 508 words

→

Pathway Diagram

flowchart TD
    MAX["MAX
Transcription Factor"]
    
    CGAS["cGAS
DNA Sensor"]
    STING["STING
Innate Immunity"]
    PARP1["PARP1
DNA Repair"]
    
    Neurodegeneration["Neurodegeneration
Progressive Loss"]
    ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    MS["Multiple Sclerosis
(MS)"]
    Parkinsons["Parkinson's
Disease"]
    
    Aging["Cellular
Aging"]
    Autoimmune["Autoimmune
Response"]
    Cancer["Cancer
Development"]
    Tumor["Tumor
Formation"]
    
    Inflammation["Chronic
Inflammation"]
    DNA_Damage["DNA Damage
Response"]
    Cell_Death["Neuronal
Cell Death"]
    Therapeutic["Therapeutic
Target"]
    
    MAX -->|"inhibits"| CGAS
    MAX -->|"inhibits"| STING
    MAX -->|"inhibits"| PARP1
    
    CGAS -->|"activates"| STING
    STING -->|"promotes"| Inflammation
    PARP1 -->|"responds to"| DNA_Damage
    
    MAX -->|"regulates"| Aging
    MAX -->|"associated with"| Neurodegeneration
    MAX -->|"activates"| ALS
    MAX -->|"activates"| MS
    MAX -->|"associated with"| Parkinsons
    
    Inflammation -->|"contributes to"| Neurodegeneration
    DNA_Damage -->|"leads to"| Cell_Death
    Aging -->|"promotes"| Neurodegeneration
    
    MAX -->|"activates"| Autoimmune
    Autoimmune -->|"triggers"| MS
    
    MAX -->|"therapeutic target"| Therapeutic
    
    style MAX fill:#006494
    style PARP1 fill:#4a1a6b
    style CGAS fill:#4a1a6b
    style STING fill:#4a1a6b
    style Therapeutic fill:#1b5e20
    style Neurodegeneration fill:#5d4400
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Parkinsons fill:#ef5350
    style Inflammation fill:#ef5350
    style Cell_Death fill:#ef5350
    style Autoimmune fill:#ef5350
    style Cancer fill:#ef5350
    style Aging fill:#5d4400

Outgoing (136)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.85
Cancer	inhibits	disease	0.85
Als	inhibits	disease	0.75
Neurodegeneration	therapeutic_target	disease	0.75
Aging	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
MYC	interacts_with	gene	0.70
MYC	inhibits	gene	0.70
Myelodysplastic Syndrome	inhibits	disease	0.65
Cancer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Als	activates	disease	0.65
Autoimmune	activates	disease	0.65
Ms	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	activates	disease	0.65
ALS	inhibits	disease	0.65
Tumor	activates	disease	0.65
Encephalitis	activates	disease	0.65
Depression	transports	disease	0.65
Leukemia	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Neuroblastoma	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Depression	activates	disease	0.65
Immune Response	inhibits	pathway	0.60
Endocytosis	interacts_with	pathway	0.60
Oxidative Phosphorylation	expressed_in	pathway	0.60
DNA	inhibits	gene	0.60
Endocytosis	inhibits	pathway	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
PER	associated_with	gene	0.60
Oxidative Phosphorylation	associated_with	pathway	0.60
MITOPHAGY	associated_with	gene	0.60

Incoming (73)

Source	Relation	Type	Str
CANCER	inhibits	gene	0.80
IFN	inhibits	gene	0.60
AQUAPORIN-4	activates	gene	0.60
CANCER	activates	gene	0.60
ERBB3	regulates	gene	0.60
PARKINSON'S DISEASE	degrades	gene	0.60
PARKINSON	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
AGING	regulates	gene	0.60
DEPRESSION	transports	gene	0.60
DNA	inhibits	gene	0.60
GENES	associated_with	gene	0.60
ASTROCYTE	transports	gene	0.60
FUT8	regulates	gene	0.60
EGFR	regulates	gene	0.60
PARP1	inhibits	gene	0.60
IRF3	inhibits	gene	0.60
MID51	regulates	gene	0.60
MID49	regulates	gene	0.60
MIRO1	regulates	gene	0.60
MTDNA	expressed_in	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
PER	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
P53	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
GENES	interacts_with	gene	0.60
MAO	inhibits	gene	0.60
GAIN	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
RNA	associated_with	gene	0.60
TOMM20	regulates	gene	0.60
AQP4	activates	gene	0.60
APP	regulates	gene	0.60
ST6GAL1	regulates	gene	0.60
PLA2G6	therapeutic_target	gene	0.60
PANK2	therapeutic_target	gene	0.60
STING	inhibits	gene	0.60
CGAS	inhibits	gene	0.60
MFF	regulates	gene	0.60
EMD	activates	gene	0.60
BACE1	regulates	gene	0.60
OVERVIEW	expressed_in	gene	0.60
CGAS	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA	0.517	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
CSF Neurofilament Light-Triggered Astrocyte-Derived Exosome	0.450	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp
Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-00	0.323	molecular-neurobiology	How does lncRNA-0021 achieve sequence-sp

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to pro [PMID:40404995]	Groh J, Feng R, Yuan X, Liu L, Klein D,	Nature neuroscience	2025
Sirt6 protects retinal ganglion cells and optic nerve from degeneration during a [PMID:38659223]	Xia F, Shi S, Palacios E, Liu W, Buscho	Molecular therapy : the journa	2024
From Mitochondrial Function to Neuroprotection-an Emerging Role for Methylene Bl [PMID:28840449]	Tucker D, Lu Y, Zhang Q	Molecular neurobiology	2018

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAX in their description or question text

No additional research found