gene

TOMM20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOMM20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

393Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for TOMM20 — Translocase of Outer Mitochondrial Membrane 20

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🧬 Gene Info

Gene Symbol	TOMM20
Full Name	Translocase of Outer Mitochondrial Membrane 20
Chromosome	5q33.1
Protein Type	Gene
Function	is a gene located on chromosome 5q33.
Molecular Weight	18 kDa
Amino Acids	169 aa
Pathways	Mitophagy
NCBI Gene ID	98004
Ensembl ID	ENSG00000160948
GeneCards	TOMM20
Human Protein Atlas	TOMM20
Associated Diseases	Aging, Alzheimer, Cardiovascular, Ischemia, Melanoma, Parkinson
Known Drugs/Compounds	Spautin-1
Interactions	ABP, ACTB, AGING, AIFM1, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	393 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TOMM20 — Translocase of Outer Mitochondrial Membrane 20

gene · 1654 words

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TOMM20 Protein

protein · 1544 words

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Pathway Diagram

graph TD
    TOMM20["TOMM20 Receptor"] -->|"Imports"| Proteins["Mitochondrial Proteins"]
    TOMM20 -->|"Interacts with"| AMPK["AMPK Kinase"]
    TOMM20 -->|"Associates with"| BCL2["BCL-2 Anti-apoptotic"]
    TOMM20 -->|"Activates"| COX4I1["COX4I1 / Complex IV"]
    COX4I1 -->|"Drives"| OXPHOS["Oxidative Phosphorylation"]
    TOMM20 -->|"Regulates"| Autophagy["Mitophagy / Autophagy"]
    Autophagy -->|"Involves"| BNIP3L["BNIP3L Receptor"]
    Autophagy -->|"Involves"| ATG7["ATG7 Conjugation"]
    TOMM20 -->|"Interacts with"| CALCOCO2["CALCOCO2 / NDP52"]
    TOMM20 -.Dysfunction.-> Aging["Cellular Aging"]
    TOMM20 -.Linked to.-> Apoptosis["Apoptosis"]

Outgoing (213)

Target	Relation	Type	Str
Mitochondrial-Derived Vesicles	component_of	structure	0.90
MITOCHONDRIAL-DERIVED VESICLES	biomarker_for	entity	0.85
Mitochondrial-Derived Vesicles	biomarker_for	process	0.85
mitochondrial-derived vesicle biogenesis	involved_in	process	0.80
Autophagy	activates	pathway	0.80
Mitophagy	activates	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Aging	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Osteoarthritis	therapeutic_target	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	inhibits	disease	0.65
Aging	activates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cardiovascular	associated_with	disease	0.65
Infection	activates	disease	0.65
Tumor	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Cardiovascular	degrades	disease	0.65
Aging	degrades	disease	0.65
Aging	regulates	disease	0.65
Heart Failure	treats	disease	0.65
Cardiovascular	treats	disease	0.65
Cardiac	treats	disease	0.65
Macular Degeneration	activates	disease	0.65
Heart Failure	inhibits	disease	0.65
CALCOCO2	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
HSPD1	interacts_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
OPTN	activates	gene	0.60
MYO7A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
ATF3	activates	gene	0.60
PARKIN	inhibits	gene	0.60
MTOR	activates	gene	0.60
PIK3C3	activates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
Parkinson	associated_with	disease	0.60
TIMM23	interacts_with	gene	0.60

Incoming (180)

Source	Relation	Type	Str
Spautin-1	binds	compound	0.85
AUTOPHAGY	activates	gene	0.70
SQSTM1	associated_with	gene	0.70
MITOPHAGY	activates	gene	0.70
MAX	regulates	gene	0.60
ATP	inhibits	gene	0.60
LC3B	activates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
TLR	associated_with	gene	0.60
LYSOSOME	activates	gene	0.60
ROS	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
FLAVONOIDS	treats	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MFF	regulates	gene	0.60
LC3B	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60
FUNDC1	inhibits	gene	0.60
OPTINEURIN	activates	gene	0.60
ASC	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
ATP6V0D1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
ACTB	activates	gene	0.60
IL6	associated_with	gene	0.60
LC3	associated_with	gene	0.60
AMBRA1	activates	gene	0.60
FUNDC1	activates	gene	0.60
P62	activates	gene	0.60
PHB2	interacts_with	gene	0.60
ATP	activates	gene	0.60
NIX	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
MITOPHAGY	degrades	gene	0.60
LC3B	expressed_in	gene	0.60
GFM1	biomarker_for	gene	0.60
HSP90	biomarker_for	gene	0.60
PINK1	biomarker_for	gene	0.60
MID49	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity