gene

TOMM20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOMM20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

385Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

Page for TOMM20 — Translocase of Outer Mitochondrial Membrane 20

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🧬 Gene Info

Gene Symbol	TOMM20
Full Name	Translocase of Outer Mitochondrial Membrane 20
Chromosome	5q33.1
Protein Type	Gene
Function	is a gene located on chromosome 5q33.
Molecular Weight	18 kDa
Amino Acids	169 aa
Pathways	Mitophagy
NCBI Gene ID	98004
Ensembl ID	ENSG00000160948
GeneCards	TOMM20
Human Protein Atlas	TOMM20
Associated Diseases	Aging, Alzheimer, Cardiovascular, Ischemia, Melanoma, Parkinson
Known Drugs/Compounds	Spautin-1
Interactions	ABP, ACTB, AGING, AIFM1, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	385 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TOMM20 — Translocase of Outer Mitochondrial Membrane 20

gene · 1654 words

→

TOMM20 Protein

protein · 1544 words

→

Pathway Diagram

graph TD
    TOMM20["TOMM20 Receptor"] -->|"Imports"| Proteins["Mitochondrial Proteins"]
    TOMM20 -->|"Interacts with"| AMPK["AMPK Kinase"]
    TOMM20 -->|"Associates with"| BCL2["BCL-2 Anti-apoptotic"]
    TOMM20 -->|"Activates"| COX4I1["COX4I1 / Complex IV"]
    COX4I1 -->|"Drives"| OXPHOS["Oxidative Phosphorylation"]
    TOMM20 -->|"Regulates"| Autophagy["Mitophagy / Autophagy"]
    Autophagy -->|"Involves"| BNIP3L["BNIP3L Receptor"]
    Autophagy -->|"Involves"| ATG7["ATG7 Conjugation"]
    TOMM20 -->|"Interacts with"| CALCOCO2["CALCOCO2 / NDP52"]
    TOMM20 -.Dysfunction.-> Aging["Cellular Aging"]
    TOMM20 -.Linked to.-> Apoptosis["Apoptosis"]

Outgoing (210)

Target	Relation	Type	Str
Mitochondrial-Derived Vesicles	component_of	structure	0.90
Mitochondrial-Derived Vesicles	biomarker_for	process	0.85
MITOCHONDRIAL-DERIVED VESICLES	biomarker_for	entity	0.85
mitochondrial-derived vesicle biogenesis	involved_in	process	0.80
Autophagy	activates	pathway	0.80
Mitophagy	activates	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
neurodegeneration	biomarker_for	disease	0.70
AUTOPHAGY	activates	gene	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Ms	inhibits	disease	0.65
Cardiovascular	treats	disease	0.65
Cardiovascular	degrades	disease	0.65
Inflammation	activates	disease	0.65
Aging	inhibits	disease	0.65
Macular Degeneration	activates	disease	0.65
Aging	degrades	disease	0.65
Bacterial Infection	activates	disease	0.65
Alzheimer	activates	disease	0.65
Infection	activates	disease	0.65
Heart Failure	treats	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	inhibits	disease	0.65
Osteoarthritis	therapeutic_target	disease	0.65
Cardiac	treats	disease	0.65
Melanoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Aging	activates	disease	0.65
Aging	regulates	disease	0.65
Ischemia	associated_with	disease	0.65
Heart Failure	inhibits	disease	0.65
Cardiovascular	activates	disease	0.65
HSPD1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
PRKN	associated_with	gene	0.60
PRKN	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
COX4I1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
TIMM23	interacts_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
XBP1	activates	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
PARKIN	activates	gene	0.60
TIMM22	inhibits	gene	0.60
MAP1LC3A	associated_with	gene	0.60

Incoming (175)

Source	Relation	Type	Str
Spautin-1	binds	compound	0.85
MITOPHAGY	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
SQSTM1	associated_with	gene	0.70
MAX	regulates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60
PTEN	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
PRKN	activates	gene	0.60
HSPD1	activates	gene	0.60
PINK1	inhibits	gene	0.60
ABP	activates	gene	0.60
BCL2	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CASP3	activates	gene	0.60
GAPDH	activates	gene	0.60
HTT	activates	gene	0.60
LC3	activates	gene	0.60
MFF	activates	gene	0.60
NBR1	activates	gene	0.60
NDP52	activates	gene	0.60
NLRX1	activates	gene	0.60
TIMM23	activates	gene	0.60
TMEM59	activates	gene	0.60
LC3B	associated_with	gene	0.60
LC3B	activates	gene	0.60
AGING	regulates	gene	0.60
INFLAMMATION	activates	gene	0.60
TLR	associated_with	gene	0.60
LYSOSOME	activates	gene	0.60
ROS	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
ALZHEIMER	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
DNA	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
ATP	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How can subcellular compartmentalization defects be measured as biomarkers in li

neuroscience | 2026-04-10 | 5 hypotheses Top: 0.724

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The clinical trialist identified this as a 'fatal clinical flaw' - no validated

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TOMM20 in their description or question text

No additional research found