Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microglial Senescence: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegenerative Disease | involved_in | disease | 0.85 |
| Aging-Related Neurodegenerative Disease Pathogenesis | contributes_to | mechanism | 0.85 |
| Neurodegenerative Disease | risk_factor_for | disease | 0.85 |
| Neurodegeneration Progression | contributes_to | process | 0.85 |
| Neuroinflammation | associated_with | process | 0.85 |
| Neurodegeneration | contributes_to | process | 0.85 |
| neurodegeneration vulnerability | causes (creates a feed-forward loop of neuroinflammation l) | disease | 0.85 |
| phagocytosis capacity | suppresses | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CGAS | involved_in | gene | 0.85 |
| cGAS-STING pathway activation | causes (age-related activation of cGAS-STING drives microg) | pathway | 0.85 |
| Apoe4 | upregulates | biomarker | 0.80 |
| TREM2 | modulates | gene | 0.80 |
| NLRP3 Inflammasome | associated_with | pathway | 0.80 |
| Aging | associated_with | process | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-Dependent Microglial Senescence Transition | 0.736 | neurodegeneration | Gene expression changes in aging mouse b |
| SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc | 0.600 | neurodegeneration | Gene expression changes in aging mouse b |
| CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli | 0.580 | neurodegeneration | Lipid raft composition changes in synapt |
| TREM2-Mediated Cholesterol Dysregulation in Microglial Senes | 0.574 | neurodegeneration | Gene expression changes in aging mouse b |
| Selective Microglial Senescence Targeting via TREM2 Modulati | 0.290 | - | Senescent cell clearance as neurodegener |
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674
neurodegeneration | 2026-04-06 | 0 hypotheses
neurodegeneration | 2026-04-03 | 34 hypotheses Top: 0.736
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793] | ["Wang R", "Feng Y", "Zhou Z", "Jiang J" | Frontiers in aging neuroscienc | 2026 | 0 |
| Human CSF proteogenomics links genetic variation to neurodegenerative disease pr [PMID:41757182] | ["Puerta R", "Garc\u00eda-Gonz\u00e1lez | medRxiv : the preprint server | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412] | Villani A, Wittmann J, Wyss T, Mallona I | Commun Biol | 2026 | 0 |
| Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Ax [PMID:41963086] | Pottorf TS, Lane EL, Haley-Johnson Z, Uk | J Neurosci | 2026 | 0 |
| TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to pro [PMID:41965330] | Wang X, Zhou H, Zhai Y, Zhang Y, Cheng Y | Cell Death Discov | 2026 | 0 |
| Investigating the Potential of Gene Editing Technologies in Enhancing Stem Cell [PMID:41926312] | ["Mehrabadi S"] | Current aging science | 2026 | 0 |
| TREM2 in neurodegeneration and diseases. [PMID:41792456] | ["Abdulkhaliq A", "Alasiri G", "Kim B", | Molecular psychiatry | 2026 | 0 |
| Berbamine hydrochloride as a brain penetrant galectin 3 inhibitor in a model of [PMID:41772384] | ["Siew J", "Lee C", "Chen H", "Lin H", " | Brain : a journal of neurology | 2026 | 0 |
| The microglial TREM2 receptor programs hippocampal development in a mouse model [PMID:41887542] | Ahmed S, Bowers C, Munoz-Martin J, Jamwa | Brain, behavior, and immunity | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial n [PMID:41881962] | Baek S, Jang J, Yeo S, Jung HJ, Choe Y | Signal transduction and target | 2026 | 0 |
| Phagocytes as plaque catalysts: Human macrophages generate seeding-competent Aβ4 [PMID:41770935] | ["Konstantoulea K", "Ramakers M", "Borri | Proceedings of the National Ac | 2026 | 0 |