Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SASP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SASP |
| Summary | Comprehensive page on senescence-associated secretory phenotype in neurodegenerative diseases |
| Key Genes/Proteins | NFKB1, NF-κB, NFKB |
| Related Diseases | Aβ-induced neurotoxicity, tau-induced neurotoxicity |
| Linked Hypotheses | 10 hypotheses |
Knowledge base pages for this entity
graph TD
SASP["SASP"]
SASP -->|"expressed in"| Senescent_Microglia["Senescent Microglia"]
SASP -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
SASP -->|"mediates"| chronic_inflammation["chronic inflammation"]
SASP -->|"promotes"| tissue_dysfunction["tissue dysfunction"]
SASP -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
SASP -.biomarker for.-> Cellular_Senescence["Cellular Senescence"]
NF__B["NF-kappaB"] -->|"activates"| SASP
NFKB["NFKB"] -->|"regulates"| SASP
senescence["senescence"] -->|"causes"| SASP
senescent_cells["senescent cells"] -->|"develops"| SASP
NFKB1["NFKB1"] -->|"promotes"| SASP
Senescent_Microglia -->|"expressed in"| SASP
senomorphics["senomorphics"] -->|"inhibits"| SASP| Target | Relation | Type | Str |
|---|---|---|---|
| Senescent Microglia | expressed_in | cell_type | 0.95 |
| Senescent Microglia | associated_with | cell_type | 0.95 |
| chronic inflammation | mediates | process | 0.90 |
| chronic inflammation | promotes | process | 0.90 |
| tissue dysfunction | promotes | process | 0.90 |
| neuroinflammation | promotes | process | 0.90 |
| Aβ-induced neurotoxicity | promotes | phenotype | 0.90 |
| tau-induced neurotoxicity | promotes | phenotype | 0.90 |
| Neuroinflammation | contributes_to | process | 0.90 |
| Neuroinflammation | causes | process | 0.90 |
| Alzheimer's Disease | contributes_to | disease | 0.85 |
| Cellular Senescence | biomarker_for | process | 0.85 |
| MICROGLIA | interacts_with | cell_type | 0.85 |
| Neurodegeneration | promotes | process | 0.85 |
| Neuroinflammation | associated_with | process | 0.85 |
| neuroinflammation | activates | pathway | 0.80 |
| SENESCENCE | associated_with | entity | 0.80 |
| Alzheimer'S Disease | contributes_to | disease | 0.80 |
| neuroinflammation | induces | process | 0.80 |
| fibrosis | activates | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Senescent Microglia | associated_with | cell_type | 0.95 |
| senescent cells | develops | cell_type | 0.95 |
| NFKB1 | promotes | protein | 0.95 |
| NF-κB | activates | protein | 0.95 |
| NFKB | regulates | entity | 0.95 |
| NFKB | activates | protein | 0.95 |
| senescence | causes | process | 0.95 |
| Senescent Microglia | expressed_in | cell_type | 0.90 |
| senomorphics | inhibits | drug | 0.90 |
| SDA-2026-04-01-gap-013 | investigates | analysis | 0.90 |
| senescent glial cells | mediates | cell_type | 0.90 |
| Cys-D | suppresses | drug | 0.85 |
| TGM2 | drives | gene | 0.85 |
| senomorphics | suppresses | drug | 0.85 |
| NF-ΚB | regulates | pathway | 0.80 |
| MICROGLIA | promotes | cell_type | 0.80 |
| NF-κB | promotes | pathway | 0.80 |
| Tgm2 | upregulates | gene | 0.80 |
| MAPK | causes | pathway | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP-Mediated Complement Cascade Amplification | 0.703 | neurodegeneration | Senolytic therapy for age-related neurod |
| SASP-Driven Microglial Metabolic Reprogramming in Synaptic P | 0.638 | neurodegeneration | Senolytic therapy for age-related neurod |
| Targeting SASP-Complement Amplification Through HIF-1α Downs | 0.610 | neurodegeneration | What molecular mechanism causes VCP muta |
| SASP-Driven Aquaporin-4 Dysregulation | 0.590 | neurodegeneration | Senolytic therapy for age-related neurod |
| Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc | 0.587 | neuroinflammation | What molecular mechanisms drive the tran |
| SASP-Mediated Cholinergic Synapse Disruption | 0.564 | neurodegeneration | Senolytic therapy for age-related neurod |
| TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S | 0.548 | cell biology | What is the relative contribution of con |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Aquaporin-4 in glymphatic system, and its implication for central nervous system [PMID:36796590] | Peng S, Liu J, Liang C, Yang L, Wang G | Neurobiol Dis | 2023 | 2 |
| Uncommon inflammatory/immune-related myelopathies. [PMID:34715593] | Valencia-Sanchez C, Flanagan EP | J Neuroimmunol | 2021 | 2 |
| Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887] | Chen TY, Wu N, Sun X | Life (Basel) | 2026 | 1 |
| Clinical, Immunological, and Vesicular Markers in Sarcopenia and Presarcopenia. [PMID:40917056] | Shuliko LM, Svarovsky DA, Spirina LV, Og | Front Biosci (Landmark Ed) | 2025 | 1 |
| CD47-blocking antibody interferes with neutrophil extracellular traps formation [PMID:39951937] | Diao Y, Hao M, Xie M, Hu X, Tan R, Wang | J Neuroimmunol | 2025 | 1 |
| Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Indu [PMID:40116141] | Xie G, Jiang G, Huang L, Sun S, Li X, Wu | CNS Neurosci Ther | 2025 | 1 |
| Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276] | Voicu V, Toader C, Șerban M, Covache-Bus | Biomedicines | 2025 | 1 |
| Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614] | Han QQ, Shen SY, Liang LF, Chen XR, Yu J | Brain Behav Immun | 2024 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455] | Cornell J, Salinas S, Huang HY, Zhou M | Neural Regen Res | 2022 | 1 |
| Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressu [PMID:31959516] | Reeves BC, Karimy JK, Kundishora AJ, Mes | Trends Mol Med | 2020 | 1 |
| Inebilizumab-cdon. [PMID:32936251] | Unknown | American journal of health-sys | 2020 | 1 |
| The glymphatic pathway in neurological disorders. [PMID:30353860] | Rasmussen MK, Mestre H, Nedergaard M | Lancet Neurol | 2018 | 1 |
| Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548] | Hong S, Beja-Glasser VF, Nfonoyim BM, Fr | Science | 2016 | 1 |
| Enhanced anticancer activity of nanoemulsified cardamom extract via modulation o [PMID:41658858] | ["Soltani T", "Karimian M", "Vaziri H", | Biochemistry and biophysics re | 2026 | 0 |
| Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular [PMID:41850064] | ["Wang H", "Liu Y", "Jiang K", "Yin J", | Poultry science | 2026 | 0 |
| Fragment merging design, synthesis, and biological evaluation of novel methyl Se [PMID:41785527] | ["Shaaban S", "Hawas S", "Elmaaty A", "B | Bioorganic & medicinal chemist | 2026 | 0 |
| Theranekron modulates extracellular matrix and apoptotic signaling pathways in c [PMID:41852375] | ["Kuccukturk S", "Duran T", "Vanli S", " | Cytotechnology | 2026 | 0 |
| Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers i [PMID:41779471] | ["Cruz-Romero S", "Baldi\u00f3n A", "Taw | Journal of applied oral scienc | 2026 | 0 |
| Glomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients W [PMID:41659822] | ["Nelson-Taylor S", "Troost J", "Giannin | Kidney medicine | 2026 | 0 |