concept

NEUROLOGICAL DISEASES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROLOGICAL DISEASES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

1Hypotheses

1Analyses

0Outgoing

33Incoming

0Experiments

1Debates

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💡 Concept Info

Name	NEUROLOGICAL DISEASES
Key Genes/Proteins	GPR37

Pathway Diagram

graph TD
    NEUROLOGICAL_DISEASES["NEUROLOGICAL DISEASES"]
    mTOR["mTOR"] -->|"risk_factor_for"| NEUROLOGICAL_DISEASES
    HDAC_Inhibitors["HDAC Inhibitors"] -->|"treats"| NEUROLOGICAL_DISEASES
    STING["STING"] -->|"targets"| NEUROLOGICAL_DISEASES
    Thyroid_Hormone_Transport_Defe["Thyroid Hormone Transport Defects"] -->|"risk_factor_for"| NEUROLOGICAL_DISEASES
    Microglia["Microglia"] -->|"targets"| NEUROLOGICAL_DISEASES
    Cns_Macrophages["Cns Macrophages"] -->|"involved_in"| NEUROLOGICAL_DISEASES
    HCN4["HCN4"] -->|"implicated in"| NEUROLOGICAL_DISEASES

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (33)

Source	Relation	Type	Str
STING	associated_with	protein	0.95
mTOR	risk_factor_for	protein	0.90
microbiota-gut-brain axis	implicated_in	pathway	0.90
SHH	therapeutic_target	protein	0.88
Hdac Inhibitors	treats	drug	0.88
HDAC Inhibitors	treats	drug	0.85
Swi/Snf Mutations	causes	biomarker	0.85
STING	targets	protein	0.85
Optogenetic Stimulation	treats	process	0.85
Optogenetic Modulation	treats	mechanism	0.82
Microglia	involved_in	cell_type	0.80
neurovascular unit	associated_with	cell_type	0.80
Thyroid Hormone Transport Defect	contributes_to	phenotype	0.80
gut microbiota	implicated_in	cell_type	0.80
GFAP	biomarker_for	protein	0.80
Microglia	targets	cell_type	0.80
Cns Macrophages	involved_in	cell_type	0.80
optogenetic stimulation	treats	process	0.80
Thyroid Hormone Transport Defects	risk_factor_for	mechanism	0.80
Tryptophan Metabolites	associated_with	compound	0.80
GPR37	implicated_in	gene	0.80
PI3K/AKT	associated_with	pathway	0.75
cathepsin dysfunction	associated_with	phenotype	0.70
NBR1	associated_with	protein	0.70
OPTN	associated_with	protein	0.70
selective autophagy	associated_with	process	0.70
mitophagy	associated_with	process	0.70
NF-κB	associated_with	pathway	0.65
NAD	implicated_in	gene	0.50
HCN1	implicated_in	gene	0.50
HCN2	implicated_in	gene	0.50
HCN4	implicated_in	gene	0.50
PARP1	implicated_in	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Tissue-specific interactome destabilization drives phenotype	0.280	mendelian-neurological-diseases-neurodegeneration	What molecular mechanisms drive tissue-s

Mentioning Analyses (1)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-03 | 6 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning NEUROLOGICAL DISEASES in their description or question text

No additional research found