gene

HCN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

50Outgoing

19Incoming

Summary

HCN2 - hyperpolarization-activated cyclic nucleotide-gated channel 2

View on Wiki →

🧬 Gene Info

Gene Symbol	HCN2
Full Name	Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2
Chromosome	19q13.4
Function	HCN2 channels are voltage-gated cation channels that pass both Na+ and K+ currents with unusual gating properties.
Primary Expression	the sinoatrial (SA) node and atrioventricular (AV) node
Molecular Weight	95 kDa
UniProt ID	Q9P0R3
NCBI Gene ID	6138
Ensembl ID	ENSG00000145214
OMIM	616383
GeneCards	HCN2
Human Protein Atlas	HCN2
Pacemaker Current	Generates Ih, a depolarizing current activated by hyperpolarization
Resting Potential	Contributes to setting and stabilizing the resting membrane potential
Synaptic Integration	Modulates dendritic integration and synaptic plasticity
Associated Diseases	AD, ALS, AMI, ARM, Absence Seizures
Interactions	JUN, HCN1, GENES, AND, EPILEPSY, App
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HCN2 — AlphaFold Q9P0R3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HCN2["<b>HCN2</b>"]
    Epilepsy{"Epilepsy"}
    HCN2 -->|"inhibits"| Epilepsy
    Ms{"Ms"}
    HCN2 -->|"inhibits"| Ms
    Als{"Als"}
    HCN2 -->|"associated with"| Als
    HCN2 -->|"associated with"| Epilepsy
    Cardiac{"Cardiac"}
    HCN2 -->|"regulates"| Cardiac
    Parkinson{"Parkinson"}
    HCN2 -->|"regulates"| Parkinson
    HCN2 -->|"regulates"| Ms
    HCN2 -->|"activates"| Parkinson
    ALS{"ALS"}
    HCN2 -->|"associated with"| ALS
    HCN2 -->|"causes"| Epilepsy
    JUN["JUN"]
    HCN2 -->|"inhibits"| JUN
    GENES["GENES"]
    HCN2 -->|"inhibits"| GENES
    JUN -->|"inhibits"| HCN2
    HCN1["HCN1"]
    HCN1 -->|"inhibits"| HCN2
    HCN4["HCN4"]
    HCN4 -->|"associated with"| HCN2
    HCN1 -->|"associated with"| HCN2
    JUN -->|"causes"| HCN2
    AND["AND"]
    AND -->|"inhibits"| HCN2
    GENES -->|"causes"| HCN2
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"causes"| HCN2
    AND -->|"associated with"| HCN2
    EPILEPSY -->|"associated with"| HCN2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"regulates"| HCN2
    PARKINSON["PARKINSON"]
    PARKINSON -->|"regulates"| HCN2
    style HCN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (62)

Target	Relation	Type	Str
Absence Seizures	associated_with	disease	0.90
hippocampus	expressed_in	brain_region	0.90
Absence Seizures	contributes_to	disease	0.85
Temporal Lobe Epilepsy	downregulates	disease	0.85
ABSENCE SEIZURES	implicated_in	entity	0.85
EPILEPSY	implicated_in	entity	0.85
Epilepsy	contributes_to	disease	0.80
Epilepsy	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Cardiac	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Ms	regulates	disease	0.65
Parkinson	activates	disease	0.65
ALS	associated_with	disease	0.65
Epilepsy	causes	disease	0.65
JUN	inhibits	gene	0.60
HCN4	associated_with	gene	0.60
HCN1	inhibits	gene	0.60
HCN1	associated_with	gene	0.60
JUN	causes	gene	0.60
Rb	regulates	protein	0.60
epilepsy	associated_with	disease	0.60
HCN4	implicated_in	gene	0.60
epilepsy	inhibits	disease	0.60
GENES	inhibits	gene	0.60
GENES	causes	gene	0.60
EPILEPSY	causes	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
EPILEPSY	associated_with	gene	0.60
AND	inhibits	gene	0.60
AND	associated_with	gene	0.60
GENETIC MUTATIONS	associated_with	gene	0.60
Neuron	inhibits	cell_type	0.60
Neuron	regulates	cell_type	0.60
EPILEPSY	inhibits	gene	0.60
App	inhibits	protein	0.60
neurons	expressed_in	cell_type	0.60
Neuron	expressed_in	cell_type	0.55
epilepsy	implicated_in	disease	0.50
atrial fibrillation	implicated_in	disease	0.50
degenerative disease	implicated_in	disease	0.50
neurodegenerative disease	implicated_in	disease	0.50
neurological diseases	implicated_in	disease	0.50
neuropathic pain	implicated_in	disease	0.50
pathological conditions	implicated_in	disease	0.50
AD	implicated_in	disease	0.50

Incoming (19)

Source	Relation	Type	Str
chronic epilepsy	downregulates	phenotype	0.90
HCN1	co_expressed_with	gene	0.80
HCN1	expressed_in	gene	0.70
JUN	inhibits	gene	0.60
HCN1	inhibits	gene	0.60
HCN4	associated_with	gene	0.60
HCN1	associated_with	gene	0.60
JUN	causes	gene	0.60
HCN1	implicated_in	gene	0.60
HCN	inhibits	gene	0.60
HCN	implicated_in	gene	0.60
HCN1	activates	gene	0.60
GENES	causes	gene	0.60
EPILEPSY	causes	gene	0.60
EPILEPSY	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
EPILEPSY	inhibits	gene	0.60
HCN1	regulates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HCN2

Understanding Entity Pages

Summary

Wiki Pages (21)

HCN2 Gene - Hyperpolarization-activated Cyclic Nucleotide-gated Channel 2

ventral-anterior-thalamic-nucleus

hcn1-protein

Prefrontal Cortex Layer 5 Pyramidal Neurons

HCN4 — Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4

Thalamocortical Relay Neurons

Spinal Vestibular Nucleus (SpVN) Expanded

Nucleus Basalis Meynert Cholinergic Neurons

HCN4 Protein — HCN Channel 4

HCN and Kv Channel Modulators in Neurodegenerative Disease

HCN1 Gene

Hippocampal O-LM Interneurons

HCN1 Neurons

payload-voltage-gated-ion-channel-modulation-therapy

HCN3

Unipolar Brush Cells in Episodic Ataxia

HCN3 Protein

Centromedian-Parafascicular Complex (CM-Pf) Neurons

HCN2 Protein - Hyperpolarization-activated Cyclic Nucleotide-gated Channel 2