concept

SELECTIVE AUTOPHAGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SELECTIVE AUTOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

180Connections

7Hypotheses

4Analyses

32Outgoing

50Incoming

0Experiments

4Debates

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💡 Concept Info

Name	SELECTIVE AUTOPHAGY
Key Genes/Proteins	amyotrophic lateral sclerosis, ANXA1, ATG5, BAG3, BCL2, BECN1
Related Diseases	cancer, disease
Related Pathways	Chaperone

Pathway Diagram

graph TD
    SELECTIVE_AUTOPHAGY["SELECTIVE AUTOPHAGY"]
    style SELECTIVE_AUTOPHAGY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    SELECTIVE_AUTOPHAGY -->|"targets"| PEDV_N_protein([PEDV N protein])
    SELECTIVE_AUTOPHAGY -.->|"degrades"| PEDV_N([PEDV N])
    SELECTIVE_AUTOPHAGY -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    SELECTIVE_AUTOPHAGY -.->|"inhibits"| STAT2([STAT2])
    SELECTIVE_AUTOPHAGY -->|"component_of"| Mitophagy["Mitophagy"]
    SELECTIVE_AUTOPHAGY -->|"component_of"| Xenophagy["Xenophagy"]
    SELECTIVE_AUTOPHAGY -->|"component_of"| Aggrephagy["Aggrephagy"]
    SELECTIVE_AUTOPHAGY -->|"involved_in"| Cancer["Cancer"]
    SELECTIVE_AUTOPHAGY -->|"involved_in"| Mitochondria["/Mitochondria/"]
    SELECTIVE_AUTOPHAGY -->|"mediates"| Protein_Degradation["Protein Degradation"]
    ULK1([ULK1]) -->|"involved_in"| SELECTIVE_AUTOPHAGY
    SQSTM1([SQSTM1]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    SQSTM1G427R([SQSTM1G427R]) -.->|"inhibits"| SELECTIVE_AUTOPHAGY
    TOLLIP([TOLLIP]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    CALCOCO2([CALCOCO2]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    Parkin([Parkin]) -->|"activates"| SELECTIVE_AUTOPHAGY
    PRKN([PRKN]) -->|"activates"| SELECTIVE_AUTOPHAGY
    NDP52([NDP52]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    Ubiquitin_Phosphorylation["Ubiquitin Phosphorylation"] -->|"mediates"| SELECTIVE_AUTOPHAGY

Outgoing (32)

Target	Relation	Type	Str
Neurodegeneration	protects_against	disease	0.95
Pedv N Protein	mediates	protein	0.95
Cancer	associated_with	disease	0.95
neurodegeneration	protects_against	disease	0.95
PEDV N	degrades	protein	0.95
PEDV N protein	targets	protein	0.95
Mitophagy	component_of	process	0.90
Mitochondria	involved_in	cell_type	0.90
Btk Inhibitors	associated_with	drug	0.90
Aggressive Lymphomas	associated_with	disease	0.90
STAT2	inhibits	protein	0.90
Xenophagy	component_of	process	0.90
Aggrephagy	component_of	process	0.90
Neurodegenerative Diseases	involved_in	disease	0.85
Protein Degradation	mediates	process	0.85
Autophagy Initiation	mediates	process	0.80
Infection	associated_with	disease	0.80
Mitophagy	involved_in	process	0.80
ubiquitination	promotes	process	0.80
Neurodegeneration	associated_with	disease	0.80
senescence-associated secretory phenotype	regulates	phenotype	0.78
UBIQUITIN	upstream_of	protein	0.75
neurological diseases	associated_with	disease	0.70
neurodegeneration	associated_with	disease	0.70
infection	associated_with	disease	0.70
RAPAMYCIN	activates	concept	0.50
PEROXISOME	activates	concept	0.50
STEM CELLS	activates	concept	0.50
AUTOPHAGOSOME	associated_with	concept	0.50
ENDOPLASMIC RETICULUM	associated_with	concept	0.50
α-SYNUCLEIN	decreases_risk	concept	0.50
AUTOPHAGOSOME	interacts_with	concept	0.50

Incoming (148)

Source	Relation	Type	Str
SQSTM1	mediates	gene	0.95
ULK1	involved_in	protein	0.95
Mitochondria	substrate_of	organelle	0.90
Ubiquitin Phosphorylation	mediates	mechanism	0.90
SQSTM1	involved_in	protein	0.90
p62	activates	protein	0.90
TBK1	regulates	gene	0.90
p62/SQSTM1	regulates	protein	0.90
SQSTM1	participates_in	protein	0.90
SQSTM1G427R	inhibits	protein	0.90
TOLLIP	participates_in	protein	0.90
CALCOCO2	participates_in	protein	0.90
Parkin	activates	gene	0.90
PRKN	activates	gene	0.90
NDP52	participates_in	protein	0.90
SQSTM1	regulates	protein	0.90
MARCHF8	involved_in	enzyme	0.90
ATG5	involved_in	gene	0.90
PEDV N PROTEIN	modulates	protein	0.90
CALCOCO2	regulates	protein	0.90
P62	involved_in	protein	0.85
OPTN	involved_in	protein	0.85
NDP52	involved_in	protein	0.85
ISG15	regulates	gene	0.85
NBR1	involved_in	protein	0.85
Parkin	associated_with	protein	0.85
Molecular Markers	biomarker_for	biomarker	0.85
Proteasomes	substrate_of	organelle	0.85
TBK1	regulates	protein	0.85
Endoplasmic Reticulum	substrate_of	organelle	0.85
Small-Molecule Compounds	targets	compound	0.85
Mitophagy	involved_in	process	0.80
NDP52	regulates	protein	0.70
TBK1	activates	protein	0.70
NBR1	regulates	protein	0.70
p62	regulates	protein	0.70
OPTN	regulates	protein	0.70
PINK1	regulates	protein	0.70
P62	regulates	protein	0.70
p62 LLPS	activates	process	0.70
SQSTM1	mediates	gene	0.70
Parkin	regulates	protein	0.70
TARDBP/TDP-43	activates	protein	0.50
LAMP1	activates	protein	0.50
PARKINSON	activates	gene	0.50
PPP3CB	activates	gene	0.50
Autophagy	associated_with	process	0.50
Proteins	associated_with	protein	0.50
MITOCHONDRIA	interacts_with	cell_type	0.50
cancer	interacts_with	disease	0.50

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
J-protein co-chaperone system mediates selective autophagy t	0.831	protein-biochemistry	Do chaperones selectively recognize path
TBK1-OPTN-p62 selective autophagy failure across ALS, FTD, a	0.776	multi	Cross-disease neurodegeneration mechanis
CHIP-mediated K63-linked ubiquitination redirects oligomeric	0.380	protein-biochemistry	Do chaperones selectively recognize path
Chaperone-Autophagy Coupling Prevents Aggregate Persistence	0.380	protein-folding	Can chaperone enhancement approaches ove
Chaperone-Autophagy Coupling Prevents Aggregate Persistence	0.380	protein-folding	Can chaperone enhancement approaches ove

Synaptic-Selective Autophagy Receptor Expression to Bypass A	0.370	proteomics	Quantitative proteomics of the aging syn
Pharmacological Chaperone-Mediated Selective Autophagy	0.000	-	GBA-Synuclein Loop Therapeutics for PD

Mentioning Analyses (4)

Scientific analyses that reference this entity

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.390

What determines organelle-specific autophagy selectivity in neurodegenerative di

neurodegeneration | 2026-04-08 | 2 hypotheses Top: 0.580

What determines the spatial organization of autophagy receptors at stress granul

neurodegeneration | 2026-04-08 | 5 hypotheses Top: 0.633

How do different organelle-specific autophagy pathways coordinate during neurode

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.772

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. [PMID:33168089]	Quinn PMJ, Moreira PI, Ambrósio AF, Alve	Acta neuropathologica communic	2020
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. [PMID:25803835]	Unknown	Nature neuroscience	2015
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. [PMID:25611507]	["Pickrell Alicia M", "Youle Richard J"]	Neuron	2015

Debates (4)

Multi-agent debates referencing this entity

The abstract mentions multiple organelles synchronously present structural deran

closed · Rounds: 4 · Score: 0.80 · 2026-04-21

SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

The review covers various organelle-specific autophagy types but doesn't address

closed · Rounds: 4 · Score: 0.66 · 2026-04-21

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

closed · Rounds: 4 · Score: 0.94 · 2026-04-10

Related Research

Hypotheses and analyses mentioning SELECTIVE AUTOPHAGY in their description or question text

Synaptic-Selective Autophagy Receptor Expression to Bypass Axonal Lysosome Defic

Score: 0.370 · proteomics · 2026-04-25

Synaptic-Selective Autophagy Receptor Expression to Bypass Axonal Lysosome Deficiency

Pharmacological Chaperone-Mediated Selective Autophagy

Score: 0.000 · unknown disease · 2026-04-28

Engineering selective autophagy receptors using ambroxol derivatives conjugated to AUTACs for targeted degradation of pa