gene

HCN4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCN4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

0Analyses

50Outgoing

17Incoming

Summary

Page for HCN4 — Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4

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🧬 Gene Info

Gene Symbol	HCN4
Full Name	Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4
Chromosome	15q24.1
Protein Type	Channel
Function	is a transmembrane protein that forms homotetrameric ion channels.
Primary Expression	various brain regions where it contributes to neuronal excitability, rhythmic activity, and synaptic integration
Amino Acids	919 aa
UniProt ID	Q9Y3X5
NCBI Gene ID	80216
Ensembl ID	ENSG00000138668
OMIM	607272
GeneCards	HCN4
Human Protein Atlas	HCN4
Genomic Coordinates	Chr15:73,257,977-73,314,655 (GRCh38)
RefSeq mRNA	NM_001194
Associated Diseases	AD, ALS, AMI, ARM, Absence Seizures
Interactions	JUN, AND, EPILEPSY, App, HCN, GENES
KG Connections	81 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HCN4 — AlphaFold Q9Y3X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HCN4["<b>HCN4</b>"]
    Absence_Seizures{"Absence Seizures"}
    HCN4 -->|"associated with"| Absence_Seizures
    Epilepsy{"Epilepsy"}
    HCN4 -->|"inhibits"| Epilepsy
    Ms{"Ms"}
    HCN4 -->|"inhibits"| Ms
    Als{"Als"}
    HCN4 -->|"associated with"| Als
    HCN4 -->|"associated with"| Epilepsy
    Cardiac{"Cardiac"}
    HCN4 -->|"regulates"| Cardiac
    Parkinson{"Parkinson"}
    HCN4 -->|"regulates"| Parkinson
    HCN4 -->|"regulates"| Ms
    HCN4 -->|"activates"| Parkinson
    ALS{"ALS"}
    HCN4 -->|"associated with"| ALS
    HCN4 -->|"causes"| Epilepsy
    HCN2["HCN2"]
    HCN4 -->|"associated with"| HCN2
    JUN["JUN"]
    JUN -->|"inhibits"| HCN4
    HCN1["HCN1"]
    HCN1 -->|"associated with"| HCN4
    HCN2 -->|"associated with"| HCN4
    GENES["GENES"]
    GENES -->|"inhibits"| HCN4
    JUN -->|"causes"| HCN4
    GENES -->|"causes"| HCN4
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"regulates"| HCN4
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"regulates"| HCN4
    PARKINSON["PARKINSON"]
    PARKINSON -->|"regulates"| HCN4
    AND["AND"]
    AND -->|"associated with"| HCN4
    AND -->|"inhibits"| HCN4
    style HCN4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
Sinus Node Dysfunction	causes	disease	0.95
SINUS NODE DYSFUNCTION	associated_with	entity	0.90
ATRIAL FIBRILLATION	associated_with	entity	0.90
VENTRICULAR TACHYCARDIA	associated_with	entity	0.90
ATRIOVENTRICULAR BLOCK	associated_with	entity	0.90
Sinus Node Dysfunction	associated_with	disease	0.90
Atrial Fibrillation	associated_with	disease	0.85
Ventricular Tachycardia	associated_with	disease	0.85
Atrioventricular Block	associated_with	disease	0.85
EPILEPSY	implicated_in	entity	0.85
Epilepsy	contributes_to	disease	0.80
Absence Seizures	associated_with	disease	0.75
ABSENCE SEIZURES	implicated_in	entity	0.75
Epilepsy	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Cardiac	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Ms	regulates	disease	0.65
Parkinson	activates	disease	0.65
ALS	associated_with	disease	0.65
Epilepsy	causes	disease	0.65
HCN2	associated_with	gene	0.60
HCN1	associated_with	gene	0.60
JUN	causes	gene	0.60
JUN	inhibits	gene	0.60
Rb	regulates	protein	0.60
epilepsy	associated_with	disease	0.60
epilepsy	expressed_in	disease	0.60
EPILEPSY	causes	gene	0.60
EPILEPSY	associated_with	gene	0.60
GENES	causes	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
AND	associated_with	gene	0.60
AND	inhibits	gene	0.60
GENETIC MUTATIONS	associated_with	gene	0.60
EPILEPSY	inhibits	gene	0.60
Neuron	inhibits	cell_type	0.60
Neuron	regulates	cell_type	0.60
App	inhibits	protein	0.60
Neuron	expressed_in	cell_type	0.55
epilepsy	implicated_in	disease	0.50
atrial fibrillation	implicated_in	disease	0.50
degenerative disease	implicated_in	disease	0.50
neurodegenerative disease	implicated_in	disease	0.50
neurological diseases	implicated_in	disease	0.50
neuropathic pain	implicated_in	disease	0.50

Incoming (17)

Source	Relation	Type	Str
JUN	inhibits	gene	0.60
HCN1	associated_with	gene	0.60
HCN2	associated_with	gene	0.60
JUN	causes	gene	0.60
HCN1	implicated_in	gene	0.60
HCN2	implicated_in	gene	0.60
HCN	inhibits	gene	0.60
HCN	implicated_in	gene	0.60
HCN1	expressed_in	gene	0.60
GENES	inhibits	gene	0.60
GENES	causes	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
EPILEPSY	associated_with	entity	0.60
EPILEPSY	causes	gene	0.60
EPILEPSY	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HCN4

Understanding Entity Pages

Summary

Wiki Pages (13)

HCN4 — Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4

hcn1-protein

HCN4 Protein — HCN Channel 4

HCN and Kv Channel Modulators in Neurodegenerative Disease

HCN1 Gene

HCN1 Neurons

Lateral Superior Olive (LSO) Neurons

HCN1 Protein

Medial Nucleus of the Trapezoid Body (MNTB) Neurons

HCN (Hyperpolarization-Activated Cyclic Nucleotide-Gated) Channel Neurons

Trapezoid Body Complex