Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NMNAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NMNAT2 |
| Full Name | NMN Adenylyltransferase 2 |
| Chromosome | 1p36.22 |
| Protein Type | Enzyme |
| Function | NMNAT2 is a cytosolic enzyme that catalyzes the conversion of NMN (nicotinamide mononucleotide) to NAD+ (nicotinamide adenine dinucleotide). |
| Subcellular Localization | **: Cytosolic, enriched in axons |
| Molecular Weight | 46.2 kDa |
| Pathways | Complement, Immune Response, Mapk |
| UniProt ID | Q9H0M0 |
| NCBI Gene ID | 23257 |
| Ensembl ID | ENSG00000145425 |
| OMIM | 608401 |
| GeneCards | NMNAT2 |
| Human Protein Atlas | NMNAT2 |
| Disease | Mechanism |
| Associated Diseases | neurodegeneration |
| Interactions | C4B, NRP1, COMPLEMENT, SARM1, MAPK, AND |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NMNAT2("NMNAT2")
Ms{"Ms"}
NMNAT2 -->|"activates"| Ms
Als{"Als"}
NMNAT2 -->|"activates"| Als
Inflammation{"Inflammation"}
NMNAT2 -->|"activates"| Inflammation
Neuroinflammation{"Neuroinflammation"}
NMNAT2 -->|"activates"| Neuroinflammation
Neuropathy{"Neuropathy"}
NMNAT2 -->|"activates"| Neuropathy
Mapk(["Mapk"])
NMNAT2 -->|"activates"| Mapk
C4B["C4B"]
NMNAT2 -->|"activates"| C4B
COMPLEMENT["COMPLEMENT"]
NMNAT2 -->|"activates"| COMPLEMENT
Immune_Response(["Immune Response"])
NMNAT2 -->|"activates"| Immune_Response
Complement(["Complement"])
NMNAT2 -->|"activates"| Complement
MAPK["MAPK"]
MAPK -->|"activates"| NMNAT2
SARM1["SARM1"]
SARM1 -->|"activates"| NMNAT2
AXON["AXON"]
AXON -->|"protects_against"| NMNAT2
AND["AND"]
AND -->|"activates"| NMNAT2
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"activates"| NMNAT2| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Neuropathy | activates | disease | 0.65 |
| C4B | activates | gene | 0.60 |
| NRP1 | activates | gene | 0.60 |
| Mapk | activates | pathway | 0.60 |
| COMPLEMENT | activates | gene | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| Complement | activates | pathway | 0.60 |
| SARM1 | activates | gene | 0.60 |
| macrophages | expressed_in | cell_type | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPK | activates | gene | 0.60 |
| SARM1 | activates | gene | 0.60 |
| AXON | protects_against | gene | 0.60 |
| AND | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| AXON | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||