protein

NMNAT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMNAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections
0Hypotheses
0Analyses
15Outgoing
7Incoming

Summary

Page for NMNAT2 Protein

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🔬 Protein Info
Gene SymbolNMNAT2
Full NameNMN Adenylyltransferase 2
Chromosome1p36.22
Protein TypeEnzyme
FunctionNMNAT2 is a cytosolic enzyme that catalyzes the conversion of NMN (nicotinamide mononucleotide) to NAD+ (nicotinamide adenine dinucleotide).
Subcellular Localization**: Cytosolic, enriched in axons
Molecular Weight46.2 kDa
PathwaysComplement, Immune Response, Mapk
UniProt IDQ9H0M0
NCBI Gene ID23257
Ensembl IDENSG00000145425
OMIM608401
GeneCardsNMNAT2
Human Protein AtlasNMNAT2
DiseaseMechanism
Associated Diseasesneurodegeneration
InteractionsC4B, NRP1, COMPLEMENT, SARM1, MAPK, AND
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NMNAT2 — AlphaFold Q9H0M0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

NMNAT2 Gene

gene · 584 words

NMNAT3 — Nicotinamide Mononucleotide Adenylyltransferase 3

gene · 2882 words

NMNAT1 Gene

gene · 2466 words

SARM1 NADase Inhibition for Axonal Preservation

idea · 2420 words

NAD+ Metabolism Pathway in Neurodegeneration

mechanism · 2062 words

Axonal Degeneration

mechanism · 1940 words

Pathway Diagram

graph TD
    NMNAT2("NMNAT2")
    Ms{"Ms"}
    NMNAT2 -->|"activates"| Ms
    Als{"Als"}
    NMNAT2 -->|"activates"| Als
    Inflammation{"Inflammation"}
    NMNAT2 -->|"activates"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    NMNAT2 -->|"activates"| Neuroinflammation
    Neuropathy{"Neuropathy"}
    NMNAT2 -->|"activates"| Neuropathy
    Mapk(["Mapk"])
    NMNAT2 -->|"activates"| Mapk
    C4B["C4B"]
    NMNAT2 -->|"activates"| C4B
    COMPLEMENT["COMPLEMENT"]
    NMNAT2 -->|"activates"| COMPLEMENT
    Immune_Response(["Immune Response"])
    NMNAT2 -->|"activates"| Immune_Response
    Complement(["Complement"])
    NMNAT2 -->|"activates"| Complement
    MAPK["MAPK"]
    MAPK -->|"activates"| NMNAT2
    SARM1["SARM1"]
    SARM1 -->|"activates"| NMNAT2
    AXON["AXON"]
    AXON -->|"protects_against"| NMNAT2
    AND["AND"]
    AND -->|"activates"| NMNAT2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| NMNAT2

Outgoing (15)

TargetRelationTypeStr
Msactivatesdisease0.65
Alsactivatesdisease0.65
Inflammationactivatesdisease0.65
Neuroinflammationactivatesdisease0.65
Neuropathyactivatesdisease0.65

Incoming (7)

SourceRelationTypeStr
MAPKactivatesgene0.60
SARM1activatesgene0.60
AXONprotects_againstgene0.60
ANDactivatesgene0.60
NEURODEGENERATIVE DISEASESactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found