concept

MYELIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYELIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1193Connections

12Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

MYELIN is a concept in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 472 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MYELIN
Key Genes/Proteins	MICROGLIA, ASTROCYTE, INFLAMMATION, NEURODEGENERATIVE DISEASES, OLIGODENDROCYTE
Related Diseases	Neurodegeneration, Inflammation, Als, Alzheimer, Multiple Sclerosis
Linked Hypotheses	16 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MYELIN["MYELIN"]
    MYELIN -->|"regulates"| Aging["Aging"]
    MYELIN -->|"causes"| ALS["ALS"]
    MYELIN -->|"causes"| Neuropathy["Neuropathy"]
    MYELIN -->|"causes"| Autoimmune["Autoimmune"]
    MYELIN -->|"activates"| Parkinson["Parkinson"]
    MYELIN -->|"activates"| Dementia["Dementia"]
    MYELIN -->|"activates"| Alzheimer["Alzheimer"]
    MYELIN -->|"expressed in"| Tumor["Tumor"]
    oligodendrocytes["oligodendrocytes"] -->|"produces"| MYELIN
    WAM["WAM"] -->|"inhibits"| MYELIN
    Oligodendrocyte["Oligodendrocyte"] -->|"regulates"| MYELIN
    aging["aging"] -->|"causes"| MYELIN
    AQUAPORIN_4["AQUAPORIN-4"] -.biomarker for.-> MYELIN
    PMP22["PMP22"] -->|"causes"| MYELIN
    COMPLEMENT["COMPLEMENT"] -->|"activates"| MYELIN
    AQP4["AQP4"] -->|"causes"| MYELIN
    ASTROCYTES["ASTROCYTES"] -->|"causes"| MYELIN

Outgoing (743)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
MICROGLIA	activates	gene	1.00
ASTROCYTE	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Alzheimer	activates	disease	0.95
Als	associated_with	disease	0.95
Multiple Sclerosis	therapeutic_target	disease	0.95
NEURODEGENERATIVE DISEASES	activates	gene	0.90
MICROGLIA	associated_with	gene	0.90
OLIGODENDROCYTE	activates	gene	0.90
Multiple Sclerosis	associated_with	disease	0.85
Tumor	activates	disease	0.85
Neuroinflammation	activates	disease	0.85
Inflammation	associated_with	disease	0.85
Multiple Sclerosis	activates	disease	0.85
MBP	activates	gene	0.80
Apoptosis	activates	pathway	0.80
Oxidative Stress	activates	pathway	0.80
CYTOKINES	activates	gene	0.80
MOG	activates	gene	0.80
ALZHEIMER	activates	gene	0.80
ALZHEIMER'S DISEASE	activates	gene	0.80
ASTROCYTES	activates	gene	0.80
OLIGODENDROCYTE	associated_with	concept	0.75
NEUROINFLAMMATION	associated_with	concept	0.75
Neuropathy	causes	disease	0.75
Autoimmune	causes	disease	0.75
Aging	causes	disease	0.75
Parkinson	activates	disease	0.75
Aging	associated_with	disease	0.75
Als	regulates	disease	0.75
Neuroinflammation	inhibits	disease	0.75
Als	causes	disease	0.75
Multiple Sclerosis	causes	disease	0.75
Inflammation	interacts_with	disease	0.75
Alzheimer	therapeutic_target	disease	0.75
Autoimmune	activates	disease	0.75
Multiple Sclerosis	regulates	disease	0.75
Neurodegeneration	therapeutic_target	disease	0.75
Multiple Sclerosis	biomarker_for	disease	0.75
Neurodegeneration	biomarker_for	disease	0.75
NEURODEGENERATION	associated_with	gene	0.70
OLIGODENDROCYTE	inhibits	gene	0.70
Complement	activates	pathway	0.70
Phagocytosis	activates	pathway	0.70
APOE	associated_with	gene	0.70
NEUROTOXICITY	activates	gene	0.70
Nf-Κb	activates	pathway	0.70

Incoming (450)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	1.00
APOPTOSIS	activates	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
OLIGODENDROCYTE	associated_with	gene	0.80
TNF	activates	gene	0.80
TREM2	activates	gene	0.80
WAM	inhibits	cell_type	0.72
COMPLEMENT	activates	gene	0.70
MICROGLIA	activates	gene	0.70
GENES	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
ROS	activates	gene	0.70
TAU	activates	gene	0.70
DISEASE-ASSOCIATED MICROGLIA	activates	gene	0.70
STAT3	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
AGING	associated_with	gene	0.70
AMYLOID	associated_with	gene	0.65
AXON	associated_with	gene	0.65
MOG	associated_with	gene	0.65
APP	associated_with	gene	0.65
BACE1	associated_with	gene	0.65
CYP46A1	associated_with	gene	0.65
MOG	co_discussed	gene	0.60
AQP4	co_discussed	gene	0.60
MICROGLIA	co_discussed	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
MBP	co_discussed	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
APOE	associated_with	gene	0.60
APOE	co_discussed	gene	0.60
LDLR	co_discussed	gene	0.60
AXON	co_discussed	gene	0.60
ACHE	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
MBP	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
AQUAPORIN-4	biomarker_for	gene	0.60
AQUAPORIN-4	associated_with	gene	0.60
PMP22	causes	gene	0.60
AQP4	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
MICROGLIA	causes	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
HSPA1A	activates	gene	0.60

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective Acid Sphingomyelinase Modulation Therapy	0.648	neurodegeneration	Lipid raft composition changes in synapt
Selective Neutral Sphingomyelinase-2 Inhibition Therapy	0.591	neurodegeneration	Lipid raft composition changes in synapt
Neutral Sphingomyelinase-2 Inhibition for Synaptic Protectio	0.546	neurodegeneration	Lipid raft composition changes in synapt
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
Senescence-Associated Myelin Lipid Remodeling	0.511	neurodegeneration	Senolytic therapy for age-related neurod

LXRβ-Selective Agonism as a Precision Therapeutic for APOE4-	0.505	neurodegeneration	What specific molecular mechanisms link
Oligodendrocyte Remyelination Enhancement	0.474	neurodegeneration	Gene expression changes in aging mouse b
Sphingomyelin Synthase Activators for Raft Remodeling	0.468	neurodegeneration	Lipid raft composition changes in synapt
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.454	neurodegeneration	Cell type vulnerability in Alzheimer's D
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution	0.447	neurodegeneration	Neuroinflammation resolution mechanisms
Myelin Sulfatide Restoration	0.442	neurodegeneration	Gene expression changes in aging mouse b
Oligodendrocyte-Targeted Myelin Sulfatide Restoration Therap	0.434	neurodegeneration	Which cell types show the most significa

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Role and regulatory mechanism of GPR37 in neurological diseases. [PMID:40822851]	Liu S, Bai T, Liu X, Zhao W, Li X, Sui Y	Front Cell Neurosci	2025	1
Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's di [PMID:39913287]	Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu J	Cell Rep	2025	1
Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotyp [PMID:38816399]	Gao Z, Guo X, Sun Z, Wu S, Wang Q, Huang	Schizophrenia (Heidelb)	2024	1
Inflammation and Infection in Pain and the Role of GPR37. [PMID:36430912]	Zhang Q, Bang S, Chandra S, Ji RR	Int J Mol Sci	2022	1
Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 [PMID:34678058]	Qian Z, Li H, Yang H, Yang Q, Lu Z, Wang	Sci Adv	2021	1
GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. [PMID:30010619]	Bang S, Xie YK, Zhang ZJ, Wang Z, Xu ZZ,	J Clin Invest	2018	1
Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: [PMID:21098459]	Mallat Z, Lambeau G, Tedgui A	Circulation	2010	1
Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin prod [PMID:18811942]	Godkin JD, Roberts MP, Elgayyar M, Guan	Reprod Biol Endocrinol	2008	1
Arachidonic acid analog AACOCF3 suppresses cPLA2-negative NSCLC cell proliferati [PMID:41544858]	Wang H, Wen Z, Jia Y, Tong X, Wang W et	Biochem Pharmacol	2026	0
Modification of the dermal matrix by senescence associated lipids and its functi [PMID:41690117]	["Jelleschitz S", "Kremslehner C", "Nage	Redox biology	2026	0
Coenzyme Q10 Supplementation Modulates Hepatic Lipidomic Alterations and Attenua [PMID:41754105]	Go Y, Joung H, Han SY, Chung J	Nutrients	2026	0
SMPD1 as a Potential Prognostic Biomarker in Glioma Is Associated With an Immuno [PMID:41795144]	Xu Y, Liu X, Xu B, Li Q, Zhang L, Li C,	CNS neuroscience & therapeutic	2026	0
Endogenous Ceramide 24:1 Constrains Th17-Driven Neutrophilic Inflammation by Ant [PMID:41824764]	Liu H, Aili A, Kuang Z, Cao L, Li Z, Sha	Advanced science (Weinheim, Ba	2026	0
Suspected Niemann-Pick disease type B with sea-blue histiocytosis after splenect [PMID:41791926]	Liu W, Qin L, Wang G	Journal of clinical lipidology	2026	0
Olipudase alfa treatment for pediatric acid sphingomyelinase deficiency in Egypt [PMID:41716780]	Arafa NA, Mahfouz A, Anwar S, Marzouk I	Molecular genetics and metabol	2026	0
cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activat [PMID:41495583]	["Li Xinyu", "Ding Huamin", "Qian Shuyu"	Inflammation	2026	0
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026	0
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026	0
Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progre [PMID:41342370]	Cheng Y, Huang G, Liu X, Wu C, Lian J et	Cancer Res	2026	0
Targeting senescent EGR1(+) B cells enhances immunotherapy efficacy in esophagea [PMID:41483805]	Zhou P, Zhang Y, Zhang H, Zhao P, Guo Y	Cell Rep Med	2026	0

MYELIN

Understanding Entity Pages

Summary

Wiki Pages (21)

ad-myelin-oligodendrocyte-therapy-companies

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Pathway Diagram

Outgoing (743)

Incoming (450)

Targeting Hypotheses (12)

Mentioning Analyses (5)

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

What specific gene expression signatures in aging mouse white matter predict hum

Is myelin loss in AD causal or an adaptive response to neuronal damage?

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Related Papers (20)

MYELIN

Understanding Entity Pages

Summary

Wiki Pages (21)

ad-myelin-oligodendrocyte-therapy-companies

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Corticobasal Degeneration (CBD)

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neurons — Cell Type Hierarchy

neuroinflammation

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Microglial Cells — Cell Type Hierarchy

coq10-neurodegeneration

Pathway Diagram

Outgoing (743)

Incoming (450)

Targeting Hypotheses (12)

Mentioning Analyses (5)

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

What specific gene expression signatures in aging mouse white matter predict hum

Is myelin loss in AD causal or an adaptive response to neuronal damage?

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Related Papers (20)