protein

NPTXR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPTXR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

16Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for NPTXR Protein

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	NPTXR
Full Name	Neuronal Pentraxin Receptor
Chromosome	22q13.1.
Protein Type	Receptor
Function	Neuronal Pentraxin Receptor (NPTXR) is a membrane protein that serves as the primary receptor for the neuronal pentraxin family, including NPTX1 and NPTX2.
Molecular Weight	50 kDa
Ensembl ID	ENSG00000162591
GeneCards	NPTXR
Human Protein Atlas	NPTXR
ELISA	Standard method for CSF and plasma
SimOA	For ultra-sensitive detection
Western blot	For protein analysis
IHC	For tissue localization
Associated Diseases	Als, Alzheimer, Dementia, Diabetes, Ms
Interactions	BDNF, DEMENTIA, ROS, TRKB
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NPTXR("NPTXR")
    Aging{"Aging"}
    NPTXR -->|"activates"| Aging
    Dementia{"Dementia"}
    NPTXR -->|"activates"| Dementia
    NPTXR -->|"associated_with"| Dementia
    Diabetes{"Diabetes"}
    NPTXR -->|"associated_with"| Diabetes
    Alzheimer{"Alzheimer"}
    NPTXR -->|"associated_with"| Alzheimer
    Ms{"Ms"}
    NPTXR -->|"associated_with"| Ms
    Als{"Als"}
    NPTXR -->|"associated_with"| Als
    BDNF["BDNF"]
    NPTXR -->|"activates"| BDNF
    TRKB["TRKB"]
    NPTXR -->|"activates"| TRKB
    DEMENTIA["DEMENTIA"]
    NPTXR -->|"activates"| DEMENTIA
    NPTXR -->|"associated_with"| DEMENTIA
    ALZHEIMER["ALZHEIMER"]
    NPTXR -->|"associated_with"| ALZHEIMER
    AND["AND"]
    NPTXR -->|"associated_with"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NPTXR -->|"associated_with"| ALZHEIMER_S_DISEASE
    STAT3["STAT3"]
    NPTXR -->|"associated_with"| STAT3

Outgoing (16)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Aging	activates	disease	0.65
Dementia	activates	disease	0.65
BDNF	activates	gene	0.60
TRKB	activates	gene	0.60
DEMENTIA	activates	gene	0.60
Jak-Stat	associated_with	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.60

Incoming (3)

Source	Relation	Type	Str
IL6	associated_with	gene	0.60
JAK	associated_with	gene	0.60
ROS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPTXR in their description or question text

No additional research found