pathway

Jak-Stat

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Jak-Stat: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

597Connections

0Hypotheses

0Analyses

24Outgoing

50Incoming

Summary

Jak-Stat is a biological pathway involved in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with ALS, Aging, Als. Connected to 308 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Jak-Stat
Key Genes/Proteins	STAT3, JAK, INFLAMMATION, NF-ΚB, CANCER, PI3K
Related Diseases	Inflammation, Als, Cancer

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Jak_Stat["Jak-Stat"] -->|"interacts"| Mtor["Mtor"]
    Jak_Stat["Jak-Stat"] -->|"interacts"| Nf__b["Nf-Kappab"]
    Jak_Stat["Jak-Stat"] -->|"interacts"| Mapk["Mapk"]
    STAT3["STAT3"] -->|"therapeutic target"| Jak_Stat["Jak-Stat"]
    SOX2["SOX2"] -->|"activates"| Jak_Stat["Jak-Stat"]
    IL6["IL6"] -->|"activates"| Jak_Stat["Jak-Stat"]
    STAT3_1["STAT3"] -->|"activates"| Jak_Stat["Jak-Stat"]
    style Jak_Stat fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
Mtor	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Invasion	activates	pathway	0.50
CELL PROLIFERATION	activates	concept	0.50
STEM CELLS	activates	concept	0.50
IL-17	activates	concept	0.50
NEURONS	activates	concept	0.50
NEURONS	associated_with	concept	0.50
Epithelial Cell	inhibits	cell_type	0.50
RAPAMYCIN	activates	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
Stem Cell	activates	cell_type	0.50
Epithelial	activates	cell_type	0.50
Neuron	causes	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Microglia	activates	cell_type	0.50
T Cell	activates	cell_type	0.50
Epithelial	inhibits	cell_type	0.50
Astrocyte	expressed_in	cell_type	0.50
Microglia	therapeutic_target	cell_type	0.50
Stem Cell	therapeutic_target	cell_type	0.50
Astrocyte	therapeutic_target	cell_type	0.50

Incoming (559)

Source	Relation	Type	Str
STAT3	activates	gene	1.00
JAK	activates	gene	1.00
Inflammation	activates	disease	1.00
Als	therapeutic_target	disease	1.00
JAK	inhibits	gene	1.00
INFLAMMATION	activates	gene	1.00
Als	activates	disease	0.90
Cancer	activates	disease	0.80
INFLAMMATION	therapeutic_target	gene	0.80
JAK	regulates	gene	0.80
JAK	associated_with	gene	0.80
NF-ΚB	associated_with	gene	0.80
CANCER	associated_with	gene	0.80
PI3K	regulates	gene	0.80
AKT	regulates	gene	0.80
CYTOKINES	therapeutic_target	gene	0.80
CANCER	activates	gene	0.80
CANCER	regulates	gene	0.80
Als	regulates	disease	0.80
Als	inhibits	disease	0.80
IL-6	activates	gene	0.80
Cancer	regulates	disease	0.75
Obesity	activates	disease	0.70
Cancer	therapeutic_target	disease	0.70
DNA	activates	gene	0.70
TNF	activates	gene	0.70
Leukemia	therapeutic_target	disease	0.70
Autoimmune	therapeutic_target	disease	0.70
Alzheimer	therapeutic_target	disease	0.70
STAT1	inhibits	gene	0.70
JAK	therapeutic_target	gene	0.70
CANCER	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
INFLAMMATION	associated_with	gene	0.70
STAT3	regulates	gene	0.70
IL-6	regulates	gene	0.70
CYTOKINES	activates	gene	0.70
PI3K	associated_with	gene	0.70
MTOR	associated_with	gene	0.70
AKT	associated_with	gene	0.70
Cancer	associated_with	disease	0.70
JAK	implicated_in	gene	0.70
TNF	inhibits	gene	0.70
CYTOKINES	inhibits	gene	0.70
IL-6	inhibits	gene	0.70
INFLAMMATION	inhibits	gene	0.70
TNF-Α	inhibits	gene	0.70
Tumor	inhibits	disease	0.70
Infection	inhibits	disease	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Jak-Stat

Understanding Entity Pages

Summary

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Device Therapies Comparison for CBS/PSP

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

Astrocyte Reactivity Mechanism

Growth Factor Therapies

APOC4 — Apolipoprotein C-IV

nlrc5-protein

Neuroprotection Strategies in Neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

JAK-STAT Signaling Pathway in Neurodegeneration

vegfr-signaling-neurodegeneration

IL28B (Interleukin 28B)